Functional Insights in PLS3-Mediated Osteogenic Regulation.

Zebrafish / metabolism Animals Osteogenesis / genetics Humans Microfilament Proteins / metabolism Membrane Glycoproteins / metabolism Cell Differentiation Mice Fibroblasts / metabolism Osteoblasts / metabolism Zebrafish Proteins / metabolism Gene Knockdown Techniques
actin-bundling protein osteogenic differentiation osteoporosis plastin-3 transcriptome

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
09 Sep 2024
Historique:
received: 15 07 2024
revised: 26 07 2024
accepted: 29 07 2024
medline: 14 9 2024
pubmed: 14 9 2024
entrez: 14 9 2024
Statut: epublish

Résumé

Plastin-3 (PLS3) encodes T-plastin, an actin-bundling protein mediating the formation of actin filaments by which numerous cellular processes are regulated. Loss-of-function genetic defects in PLS3 are reported to cause X-linked osteoporosis and childhood-onset fractures. However, the molecular etiology of PLS3 remains elusive. Functional compensation by actin-bundling proteins ACTN1, ACTN4, and FSCN1 was investigated in zebrafish following morpholino-mediated

Identifiants

DOI: 10.3390/cells13171507 PMID: 39273077
pubmed: 39273077
pii: cells13171507
doi: 10.3390/cells13171507
pii:
doi:

Substances chimiques

plastin 0
Microfilament Proteins 0
Membrane Glycoproteins 0
Zebrafish Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : FOR2722
Organisme : Guangdong Province Basic and Applied Basic Research Fund Project
ID : 2022A1515011121
Organisme : Guangzhou Elite Project
ID : JY202028

Auteurs

Wenchao Zhong (W)

Department of Human Genetics, Amsterdam UMC Location Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Department of Clinical Chemistry, Amsterdam UMC Location Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Amsterdam Movement Sciences, Tissue Function And Regeneration, 1081 HV Amsterdam, The Netherlands.
Department of Temporomandibular Joint, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510060, China.
ORCID: 0000-0002-9864-225X

Janine Neugebauer (J)

Institute of Human Genetics University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany.

Janak L Pathak (JL)

Department of Temporomandibular Joint, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510060, China.
ORCID: 0009-0008-2974-6224

Xingyang Li (X)

Department of Temporomandibular Joint, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510060, China.

Gerard Pals (G)

Department of Human Genetics, Amsterdam UMC Location Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Amsterdam Movement Sciences, Tissue Function And Regeneration, 1081 HV Amsterdam, The Netherlands.
ORCID: 0000-0003-4091-7115

M Carola Zillikens (MC)

Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 CE Rotterdam, The Netherlands.
ORCID: 0000-0001-9186-3423

Elisabeth M W Eekhoff (EMW)

Amsterdam Movement Sciences, Tissue Function And Regeneration, 1081 HV Amsterdam, The Netherlands.
Department Internal Medicine, Endocrinology and Metabolism, Amsterdam UMC Location Vrije Universiteit Amsterdam, Rare Bone Disease Center, 1081 HV Amsterdam, The Netherlands.
Amsterdam Reproduction and Development, 1105 AZ Amsterdam, The Netherlands.
ORCID: 0000-0001-5399-676X

Nathalie Bravenboer (N)

Department of Clinical Chemistry, Amsterdam UMC Location Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Amsterdam Movement Sciences, Tissue Function And Regeneration, 1081 HV Amsterdam, The Netherlands.

Qingbin Zhang (Q)

Department of Temporomandibular Joint, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510060, China.

Matthias Hammerschmidt (M)

Developmental Biology Unit, Institute of Zoology, University of Cologne, 50931 Cologne, Germany.
Center for Rare Diseases, University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
ORCID: 0000-0002-3709-8166

Brunhilde Wirth (B)

Institute of Human Genetics University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany.
Center for Rare Diseases, University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
ORCID: 0000-0003-4051-5191

Dimitra Micha (D)

Department of Human Genetics, Amsterdam UMC Location Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Amsterdam Movement Sciences, Tissue Function And Regeneration, 1081 HV Amsterdam, The Netherlands.
Amsterdam Reproduction and Development, 1105 AZ Amsterdam, The Netherlands.
ORCID: 0000-0001-7890-4411

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Functional Insights in PLS3-Mediated...
Recherchemedicale.com › Eucaryotes › Animaux › Functional Insights in PLS3-Mediated...
Recherchemedicale.com › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › Functional Insights in PLS3-Mediated...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Functional Insights in PLS3-Mediated...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Functional Insights in PLS3-Mediated...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Functional Insights in PLS3-Mediated...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Functional Insights in PLS3-Mediated...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Functional Insights in PLS3-Mediated...
Recherchemedicale.com › Cellules › Cellules du tissu conjonctif › Fibroblastes › Functional Insights in PLS3-Mediated...
Recherchemedicale.com › Cellules › Cellules du tissu conjonctif › Ostéoblastes › Functional Insights in PLS3-Mediated...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines de poisson › Protéines de poisson-zèbre › Functional Insights in PLS3-Mediated...
Recherchemedicale.com › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-down de gènes › Functional Insights in PLS3-Mediated...