Oncostatin M receptor-dependent signaling assessed by RNA sequencing in mouse hematopoietic stem cells.


Journal

Scientific data
ISSN: 2052-4463
Titre abrégé: Sci Data
Pays: England
ID NLM: 101640192

Informations de publication

Date de publication:
12 Sep 2024
Historique:
received: 19 02 2024
accepted: 28 08 2024
medline: 13 9 2024
pubmed: 13 9 2024
entrez: 12 9 2024
Statut: epublish

Résumé

Oncostatin M (OSM) is a member of the interleukin-6 (IL-6) family of cytokines and has been found to have anti-inflammatory and pro-inflammatory properties in various cellular and disease contexts. OSM signals through two receptor complexes, one of which includes OSMRβ. Here, we investigated OSM-OSMRβ signaling in adult mouse hematopoietic stem cells (HSCs) using the conditional Osmr

Identifiants

pubmed: 39266541
doi: 10.1038/s41597-024-03839-3
pii: 10.1038/s41597-024-03839-3
doi:

Substances chimiques

Oncostatin M 106956-32-5
Oncostatin M Receptor beta Subunit 0
Receptors, Oncostatin M 0

Types de publication

Journal Article Dataset

Langues

eng

Sous-ensembles de citation

IM

Pagination

996

Subventions

Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : R01DK118072
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : F31DK127573
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)
ID : U01AG077925
Organisme : U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
ID : P30CA034196

Informations de copyright

© 2024. The Author(s).

Références

Masjedi, A. et al. Oncostatin M: A mysterious cytokine in cancers. Int Immunopharmacol 90, 107158, https://doi.org/10.1016/j.intimp.2020.107158 (2021).
doi: 10.1016/j.intimp.2020.107158
Houben, E., Hellings, N. & Broux, B. Oncostatin M, an Underestimated Player in the Central Nervous System. Front Immunol 10, 1165, https://doi.org/10.3389/fimmu.2019.01165 (2019).
doi: 10.3389/fimmu.2019.01165
Chen, M. et al. Exploring the oncostatin M (OSM) feed-forward signaling of glioblastoma via STAT3 in pan-cancer analysis. Cancer Cell Int 21, 565, https://doi.org/10.1186/s12935-021-02260-9 (2021).
doi: 10.1186/s12935-021-02260-9
Tanaka, M. & Miyajima, A. Oncostatin M, a multifunctional cytokine. Rev Physiol Biochem Pharmacol 149, 39–52, https://doi.org/10.1007/s10254-003-0013-1 (2003).
doi: 10.1007/s10254-003-0013-1
Stephens, J. M. & Elks, C. M. Oncostatin M: Potential Implications for Malignancy and Metabolism. Curr Pharm Des 23, 3645–3657, https://doi.org/10.2174/1381612823666170704122559 (2017).
doi: 10.2174/1381612823666170704122559
Zarling, J. M. et al. Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells. Proc Natl Acad Sci USA 83, 9739–9743, https://doi.org/10.1073/pnas.83.24.9739 (1986).
doi: 10.1073/pnas.83.24.9739
Malik, N. et al. Molecular cloning, sequence analysis, and functional expression of a novel growth regulator, oncostatin M. Mol Cell Biol 9, 2847–2853, https://doi.org/10.1128/mcb.9.7.2847-2853.1989 (1989).
doi: 10.1128/mcb.9.7.2847-2853.1989
Araujo, A. M. et al. Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment. J Clin Invest 132, https://doi.org/10.1172/JCI148667 (2022).
Auguste, P. et al. Signaling of type II oncostatin M receptor. J Biol Chem 272, 15760–15764, https://doi.org/10.1074/jbc.272.25.15760 (1997).
doi: 10.1074/jbc.272.25.15760
Mosley, B. et al. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J Biol Chem 271, 32635–32643, https://doi.org/10.1074/jbc.271.51.32635 (1996).
doi: 10.1074/jbc.271.51.32635
Gearing, D. P. et al. The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science 255, 1434–1437, https://doi.org/10.1126/science.1542794 (1992).
doi: 10.1126/science.1542794
Walker, E. C. et al. Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice. J Clin Invest 120, 582–592, https://doi.org/10.1172/JCI40568 (2010).
doi: 10.1172/JCI40568
Sims, N. A. Influences of the IL-6 cytokine family on bone structure and function. Cytokine 146, 155655, https://doi.org/10.1016/j.cyto.2021.155655 (2021).
doi: 10.1016/j.cyto.2021.155655
Adrian-Segarra, J. M. et al. The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice. J Biol Chem 293, 20181–20199, https://doi.org/10.1074/jbc.RA118.004375 (2018).
doi: 10.1074/jbc.RA118.004375
Drechsler, J., Grotzinger, J. & Hermanns, H. M. Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor. PLoS One 7, e43155, https://doi.org/10.1371/journal.pone.0043155 (2012).
doi: 10.1371/journal.pone.0043155
Ichihara, M., Hara, T., Kim, H., Murate, T. & Miyajima, A. Oncostatin M and leukemia inhibitory factor do not use the same functional receptor in mice. Blood 90, 165–173 (1997).
doi: 10.1182/blood.V90.1.165.165_165_173
Flohr Svendsen, A. et al. A comprehensive transcriptome signature of murine hematopoietic stem cell aging. Blood 138, 439–451, https://doi.org/10.1182/blood.2020009729 (2021).
doi: 10.1182/blood.2020009729
Sempowski, G. D. et al. Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy. J Immunol 164, 2180–2187, https://doi.org/10.4049/jimmunol.164.4.2180 (2000).
doi: 10.4049/jimmunol.164.4.2180
Kuhn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427–1429, https://doi.org/10.1126/science.7660125 (1995).
doi: 10.1126/science.7660125
Schwartz, L. S., Stearns, T., Trowbridge, J. J. & Telpoukhovskaia, M., GEO. https://identifiers.org/geo/GSE244544 (2024).
Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102, 15545–15550, https://doi.org/10.1073/pnas.0506580102 (2005).
doi: 10.1073/pnas.0506580102
Wang, E. C. E., Dai, Z., Ferrante, A. W., Drake, C. G. & Christiano, A. M. A Subset of TREM2(+) Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth. Cell Stem Cell 24, 654–669 e656, https://doi.org/10.1016/j.stem.2019.01.011 (2019).
doi: 10.1016/j.stem.2019.01.011
Bisht, K. et al. Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization. Leukemia 36, 333–347, https://doi.org/10.1038/s41375-021-01413-z (2022).
doi: 10.1038/s41375-021-01413-z

Auteurs

Logan S Schwartz (LS)

The Jackson Laboratory, Bar Harbor, ME, USA.
School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.

Ruth L Saxl (RL)

The Jackson Laboratory, Bar Harbor, ME, USA.

Tim Stearns (T)

The Jackson Laboratory, Bar Harbor, ME, USA.

Maria Telpoukhovskaia (M)

The Jackson Laboratory, Bar Harbor, ME, USA. maria.telpoukhovskaia@jax.org.

Jennifer J Trowbridge (JJ)

The Jackson Laboratory, Bar Harbor, ME, USA. Jennifer.trowbridge@jax.org.
School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA. Jennifer.trowbridge@jax.org.

Articles similaires

Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH