A Multicenter Study of COPD and Cognitive Impairment: Unraveling the Interplay of Quantitative CT, Lung Function, HIF-1α, and Clinical Variables.
Humans
Pulmonary Disease, Chronic Obstructive
/ physiopathology
Male
Cross-Sectional Studies
Female
Middle Aged
Aged
Lung
/ physiopathology
Hypoxia-Inducible Factor 1, alpha Subunit
/ blood
Cognitive Dysfunction
/ diagnosis
Cognition
Forced Expiratory Volume
Predictive Value of Tests
Risk Factors
Spirometry
Vital Capacity
Biomarkers
/ blood
Tomography, X-Ray Computed
chronic obstructive pulmonary disease
cognitive impairment
emphysema lung
hypoxia inducible factor
Journal
International journal of chronic obstructive pulmonary disease
ISSN: 1178-2005
Titre abrégé: Int J Chron Obstruct Pulmon Dis
Pays: New Zealand
ID NLM: 101273481
Informations de publication
Date de publication:
2024
2024
Historique:
received:
01
03
2024
accepted:
20
07
2024
medline:
5
8
2024
pubmed:
5
8
2024
entrez:
5
8
2024
Statut:
epublish
Résumé
The exact link between cognitive impairment (CI) and chronic obstructive pulmonary disease (COPD) is still limited. Thus, we aim to find the relationship and interaction of quantitative CT (QCT), lung function, HIF-1α, and clinical factors with the development of CI among COPD patients. A cross-sectional multicentre study was conducted from January 2022 to December 2023. We collected clinical data, spirometry, CT images, and venous blood samples from 114 COPD participants. Cognitive impairment assessment using the Montreal Cognitive Assessment Indonesian version (MoCA-Ina) with a cutoff value 26. The QCT analysis consists of lung density, airway wall thickness, pulmonary artery-to-aorta ratio (PA:A), and pectoralis muscles using 3D Slicer software. Serum HIF-1α analysis was performed using ELISA. We found significant differences between %LAA We conclude that the utilization of QCT parameters is beneficial as it can identify abnormalities and contribute to the development of CI, indicating its potential utility in clinical decision-making. The MoCA-Ina score in COPD is mainly affected by %LAA
Identifiants
pubmed: 39099608
doi: 10.2147/COPD.S466173
pii: 466173
pmc: PMC11296506
doi:
Substances chimiques
Hypoxia-Inducible Factor 1, alpha Subunit
0
HIF1A protein, human
0
Biomarkers
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1741-1753Informations de copyright
© 2024 Simargi et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.