Cell-penetrating peptide and cationic liposomes mediated siRNA delivery to arrest growth of chronic myeloid leukemia cells in vitro.

BCR-ABL1 Cationic liposomes Cell penetrating peptides siRNA

Journal

Biochimie
ISSN: 1638-6183
Titre abrégé: Biochimie
Pays: France
ID NLM: 1264604

Informations de publication

Date de publication:
10 Jan 2024
Historique:
received: 28 07 2023
revised: 09 01 2024
accepted: 09 01 2024
medline: 13 1 2024
pubmed: 13 1 2024
entrez: 12 1 2024
Statut: aheadofprint

Résumé

Gene silencing through RNA interference (RNAi) is a promising therapeutic approach for a wide range of disorders, including cancer. Non-viral gene therapy, using specific siRNAs against BCR-ABL1, can be a supportive or alternative measure to traditional chronic myeloid leukemia (CML) tyrosine kinase inhibitor (TKIs) therapies, given the prevalence of clinical TKI resistance. The main challenge for such approaches remains the development of the effective delivery system for siRNA tailored to the specific disease model. The purpose of this study was to examine and compare the efficiency of endosomolytic cell penetrating peptide (CPP) EB1 and PEG

Identifiants

DOI: 10.1016/j.biochi.2024.01.006 PMID: 38215931
pubmed: 38215931
pii: S0300-9084(24)00006-3
doi: 10.1016/j.biochi.2024.01.006
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Vera Vysochinskaya (V)

Smorodintsev Research Institute of Influenza, Russian Ministry of Health, 15/17 Ulitsa Prof. Popova, St. Petersburg, 197376, Russian Federation; Institute of Biomedical Systems and Biotechnology, Peter the Great Saint Petersburg Polytechnic University, 29 Ulitsa Polytechnicheskaya, St. Petersburg, 194064, Russian Federation. Electronic address: vera.vysochinskaya@influenza.spb.ru.

Yana Zabrodskaya (Y)

Smorodintsev Research Institute of Influenza, Russian Ministry of Health, 15/17 Ulitsa Prof. Popova, St. Petersburg, 197376, Russian Federation; Institute of Biomedical Systems and Biotechnology, Peter the Great Saint Petersburg Polytechnic University, 29 Ulitsa Polytechnicheskaya, St. Petersburg, 194064, Russian Federation.

Olesya Dovbysh (O)

Institute of Biomedical Systems and Biotechnology, Peter the Great Saint Petersburg Polytechnic University, 29 Ulitsa Polytechnicheskaya, St. Petersburg, 194064, Russian Federation.

Anton Emelyanov (A)

First Pavlov State Medical University of St. Petersburg, L'va Tolstogo str. 6-8, St. Petersburg, 197022, Russian Federation.

Vladimir Klimenko (V)

Saint Petersburg Clinical Research and Practical Center of Specialized Types of Medical Care (Oncological) named after N.P. Napalkov, St. Petersburg, 197758, Russian Federation.

Nikolay Knyazev (N)

Saint Petersburg Clinical Research and Practical Center of Specialized Types of Medical Care (Oncological) named after N.P. Napalkov, St. Petersburg, 197758, Russian Federation.

Ivan Terterov (I)

ITMO University, School of Physics and Engineering, Kronverkskiy pr. 49, St. Petersburg, 197101, Russian Federation.

Marya Egorova (M)

Smorodintsev Research Institute of Influenza, Russian Ministry of Health, 15/17 Ulitsa Prof. Popova, St. Petersburg, 197376, Russian Federation.

Alexey Bogdanov (A)

Saint Petersburg Clinical Research and Practical Center of Specialized Types of Medical Care (Oncological) named after N.P. Napalkov, St. Petersburg, 197758, Russian Federation.

Michael Maslov (M)

Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 86 Vernadsky Ave, Moscow, 119571, Russian Federation.

Andrey Vasin (A)

Smorodintsev Research Institute of Influenza, Russian Ministry of Health, 15/17 Ulitsa Prof. Popova, St. Petersburg, 197376, Russian Federation; Institute of Biomedical Systems and Biotechnology, Peter the Great Saint Petersburg Polytechnic University, 29 Ulitsa Polytechnicheskaya, St. Petersburg, 194064, Russian Federation.

Michael Dubina (M)

Russian Academy of Sciences, 14 Leninskiy pr., Moscow, 119991, Russian Federation.

Classifications MeSH