Metaflammation in obesity and its therapeutic targeting.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
22 11 2023
22 11 2023
Historique:
medline:
27
11
2023
pubmed:
22
11
2023
entrez:
22
11
2023
Statut:
ppublish
Résumé
Obesity-associated inflammation is a systemic process that affects all metabolic organs. Prominent among these is adipose tissue, where cells of the innate and adaptive immune system are markedly changed in obesity, implicating these cells in a range of processes linking immune memory to metabolic regulation. Furthermore, weight loss and weight cycling have unexpected effects on adipose tissue immune populations. Here, we review the current literature on the roles of various immune cells in lean and obese adipose tissue. Within this context, we discuss pharmacological and nonpharmacological approaches to obesity treatment and their impact on systemic inflammation.
Identifiants
pubmed: 37992150
doi: 10.1126/scitranslmed.adf9382
pmc: PMC10847980
mid: NIHMS1961427
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
eadf9382Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR002245
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK058404
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2TR002245
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007563
Pays : United States
Organisme : BLRD VA
ID : IK6 BX005649
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK121520
Pays : United States
Références
Int J Mol Sci. 2022 Jul 03;23(13):
pubmed: 35806422
Immunometabolism. 2020;2(3):
pubmed: 32774894
Front Physiol. 2021 Oct 18;12:688485
pubmed: 34733170
Diabetes. 2010 Jul;59(7):1648-56
pubmed: 20357360
J Immunol. 2010 Dec 1;185(11):6947-59
pubmed: 21037091
Nat Med. 2011 May;17(5):610-7
pubmed: 21499269
Cell. 2014 Apr 10;157(2):340-356
pubmed: 24725403
Immunity. 2016 Aug 16;45(2):428-41
pubmed: 27496734
Diabetes. 2017 Feb;66(2):392-406
pubmed: 28108608
Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5133-8
pubmed: 23479618
Eur J Immunol. 2017 Dec;47(12):2113-2123
pubmed: 28762530
Diabetes. 2016 Oct;65(10):2966-79
pubmed: 27445264
Public Health Nutr. 2006 Dec;9(8A):1073-6
pubmed: 17378943
Cardiovasc Diabetol. 2018 Jan 4;17(1):6
pubmed: 29301516
Nat Med. 2009 Aug;15(8):930-9
pubmed: 19633656
Immunol Rev. 2020 May;295(1):101-113
pubmed: 32237081
Lancet. 2019 Jan 5;393(10166):31-39
pubmed: 30424892
Nat Metab. 2022 Nov;4(11):1474-1494
pubmed: 36329217
NCHS Data Brief. 2020 Feb;(360):1-8
pubmed: 32487284
Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5096-E5105
pubmed: 29760084
Diabetologia. 2014 Apr;57(4):781-4
pubmed: 24362727
Science. 2015 Nov 20;350(6263):981-5
pubmed: 26472762
Cell Metab. 2021 Feb 2;33(2):270-282.e8
pubmed: 33278339
JCI Insight. 2021 Apr 22;6(8):
pubmed: 33724954
Cell Rep. 2017 Sep 26;20(13):3149-3161
pubmed: 28954231
Am J Epidemiol. 1989 Feb;129(2):312-8
pubmed: 2912043
Cell Metab. 2013 Dec 3;18(6):816-30
pubmed: 24315368
Am J Clin Nutr. 2011 Aug;94(2):450-8
pubmed: 21677057
Cell Metab. 2021 Sep 7;33(9):1869-1882.e6
pubmed: 34380013
Nat Immunol. 2018 May;19(5):464-474
pubmed: 29670241
J Immunol. 2016 Nov 1;197(9):3650-3661
pubmed: 27683748
Diabetes. 2018 Nov;67(11):2361-2376
pubmed: 30181158
Metabolism. 2018 Aug;85:32-37
pubmed: 29452178
J Clin Invest. 2012 Oct;122(10):3529-40
pubmed: 22996660
Diabetologia. 2019 Jul;62(7):1154-1166
pubmed: 31001673
Rom J Intern Med. 2019 Sep 1;57(3):233-240
pubmed: 30901315
J Clin Invest. 2007 Jan;117(1):175-84
pubmed: 17200717
J Immunol. 2019 Feb 15;202(4):1265-1286
pubmed: 30659108
N Engl J Med. 2019 Aug 29;381(9):841-851
pubmed: 31185157
Cardiovasc Diabetol. 2021 Mar 26;20(1):74
pubmed: 33771149
Diabetes Technol Ther. 2010 Mar;12(3):233-40
pubmed: 20151774
J Leukoc Biol. 2015 Jan;97(1):121-34
pubmed: 25395302
Atherosclerosis. 2019 Sep;288:60-66
pubmed: 31326727
N Engl J Med. 2017 Apr 6;376(14):1332-1340
pubmed: 28379800
JCI Insight. 2022 Feb 8;7(3):
pubmed: 34990410
Med. 2021 Nov 12;2(11):1203-1230
pubmed: 35590197
Diabetes Ther. 2017 Aug;8(4):821-827
pubmed: 28646412
Nat Med. 2009 Aug;15(8):914-20
pubmed: 19633658
Nat Commun. 2022 May 26;13(1):2950
pubmed: 35618862
Int J Obes (Lond). 2018 Apr;42(4):755-764
pubmed: 29762555
Cell Metab. 2016 Apr 12;23(4):591-601
pubmed: 26916363
Ann Intern Med. 2010 Mar 16;152(6):346-57
pubmed: 20231565
JACC Basic Transl Sci. 2018 Nov 21;3(6):844-857
pubmed: 30623143
Obes Surg. 2019 Aug;29(8):2631-2647
pubmed: 31093862
N Engl J Med. 2017 Jul 6;377(1):13-27
pubmed: 28604169
Circ Res. 2022 Jan 7;130(1):130-148
pubmed: 34995137
Front Immunol. 2023 Jan 11;13:984859
pubmed: 36713396
J Clin Invest. 2003 Dec;112(12):1821-30
pubmed: 14679177
Nat Med. 2017 Nov;23(11):1309-1318
pubmed: 29035364
Diabetes. 2013 Sep;62(9):3180-8
pubmed: 23733197
Diabetes. 2014 Feb;63(2):421-32
pubmed: 24130337
Diabetologia. 2012 Sep;55(9):2456-68
pubmed: 22722451
Cell Metab. 2014 Mar 4;19(3):512-26
pubmed: 24606904
Cell Metab. 2021 Aug 3;33(8):1624-1639.e9
pubmed: 34174197
Nat Immunol. 2012 Nov;13(11):1118-28
pubmed: 23023392
J Clin Med. 2019 Apr 09;8(4):
pubmed: 30970605
Biochem Pharmacol. 2018 Jun;152:45-59
pubmed: 29551587
Int J Obes (Lond). 2005 Oct;29(10):1275-80
pubmed: 16010285
J Obes. 2011;2011:989657
pubmed: 21941636
Cell Metab. 2015 May 5;21(5):678-91
pubmed: 25955205
Annu Rev Immunol. 2014;32:121-55
pubmed: 24387714
Circ Heart Fail. 2020 Jan;13(1):e006277
pubmed: 31957470
N Engl J Med. 2022 Jul 21;387(3):205-216
pubmed: 35658024
J Clin Invest. 2010 Oct;120(10):3466-79
pubmed: 20877011
Int J Mol Sci. 2017 Aug 04;18(8):
pubmed: 28777298
Diabetes Res Clin Pract. 2020 Oct;168:108368
pubmed: 32800932
Diabetologia. 2018 Apr;61(4):942-953
pubmed: 29333574
PLoS One. 2015 Mar 18;10(3):e0120918
pubmed: 25785862
Nat Med. 2011 Feb;17(2):179-88
pubmed: 21217695
Mol Metab. 2022 Dec;66:101642
pubmed: 36402403
Obes Surg. 2012 Jun;22(6):950-5
pubmed: 22527592
Nat Rev Immunol. 2020 Jun;20(6):375-388
pubmed: 32132681
Nat Med. 2009 Aug;15(8):940-5
pubmed: 19633655
Cell Metab. 2014 Oct 7;20(4):614-25
pubmed: 25242226
Cell Rep. 2014 Oct 23;9(2):605-17
pubmed: 25310975
Curr Opin Endocrinol Diabetes Obes. 2016 Oct;23(5):373-8
pubmed: 27455515
Diabetol Metab Syndr. 2018 Dec 18;10:93
pubmed: 30574207
Nature. 2012 Jun 28;486(7404):549-53
pubmed: 22722857
J Vis Exp. 2015 Nov 28;(105):
pubmed: 26649578
J Diabetes Complications. 2017 Jul;31(7):1237-1242
pubmed: 28479155
Cell Signal. 2021 Jan;77:109825
pubmed: 33160017
J Immunol. 2010 Aug 1;185(3):1836-45
pubmed: 20581149
Int J Obes (Lond). 2009 Apr;33(4):456-64
pubmed: 19238154
Nature. 2017 Oct 5;550(7674):119-123
pubmed: 28953873
Cardiovasc Drugs Ther. 2017 Apr;31(2):119-132
pubmed: 28447181
N Engl J Med. 2017 Jan 19;376(3):254-266
pubmed: 28099824
Obes Rev. 2019 Jun;20(6):816-828
pubmed: 30972878
N Engl J Med. 2017 Sep 21;377(12):1119-1131
pubmed: 28845751
Diabetes Res Clin Pract. 2005 Jul;69(1):29-35
pubmed: 15955385
Nat Commun. 2020 May 1;11(1):2127
pubmed: 32358544
Intern Med. 2021 Nov 1;60(21):3391-3399
pubmed: 33994437
Elife. 2022 Oct 20;11:
pubmed: 36264059
Nat Rev Immunol. 2016 Sep;16(9):553-65
pubmed: 27396447
Nat Rev Endocrinol. 2021 Aug;17(8):455-467
pubmed: 34163039
Science. 2011 Apr 8;332(6026):243-7
pubmed: 21436399
Diabetes Obes Metab. 2020 Mar;22(3):442-451
pubmed: 31903692
J Clin Endocrinol Metab. 2012 Jan;97(1):198-207
pubmed: 22013105
Nutr Res. 2018 Feb;50:63-72
pubmed: 29540273
JAMA. 2004 Oct 13;292(14):1724-37
pubmed: 15479938
N Engl J Med. 2016 Jul 28;375(4):311-22
pubmed: 27295427
Diabetes. 2012 Sep;61(9):2238-47
pubmed: 22596049
Diabetes Care. 2010 Aug;33(8):1734-7
pubmed: 20424219
Nat Rev Immunol. 2021 Sep;21(9):597-611
pubmed: 33772242
Cell Mol Immunol. 2018 Jun;15(6):630-639
pubmed: 28626237
Nat Immunol. 2021 May;22(5):639-653
pubmed: 33907320
Clin Sci (Lond). 2017 Mar 1;131(5):343-353
pubmed: 28049736
Nature. 2015 Mar 12;519(7542):242-6
pubmed: 25533952
Science. 2023 Jan 6;379(6627):45-62
pubmed: 36603072
PLoS One. 2015 Oct 16;10(10):e0140596
pubmed: 26474157
Signal Transduct Target Ther. 2021 Aug 4;6(1):291
pubmed: 34344870
J Biol Chem. 2007 Nov 30;282(48):35279-92
pubmed: 17916553
J Innate Immun. 2022;14(1):42-50
pubmed: 33378755
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15324-9
pubmed: 21876127
J Endocr Soc. 2020 Aug 04;4(9):bvaa049
pubmed: 32775937
J Clin Med. 2019 Nov 01;8(11):
pubmed: 31683785
Diabetes Care. 2019 May;42(5):931-937
pubmed: 30885955
Geroscience. 2022 Jun;44(3):1761-1778
pubmed: 35477832
J Biol Chem. 2010 May 14;285(20):15333-15345
pubmed: 20308074
Obesity (Silver Spring). 2016 Aug;24(8):1612-9
pubmed: 27136388
EBioMedicine. 2017 Jun;20:137-149
pubmed: 28579299
Front Immunol. 2021 Jul 26;12:719979
pubmed: 34381461
Ann N Y Acad Sci. 2008 Dec;1150:152-6
pubmed: 19120286
J Clin Invest. 2017 Jan 3;127(1):24-32
pubmed: 28045396
J Clin Invest. 2017 Jan 3;127(1):43-54
pubmed: 28045398
Nature. 2022 Mar;603(7903):926-933
pubmed: 35296864
Cardiovasc Diabetol. 2019 Jun 5;18(1):76
pubmed: 31167663
Cell. 2019 Jul 25;178(3):686-698.e14
pubmed: 31257031
Obesity (Silver Spring). 2010 Oct;18(10):1918-25
pubmed: 20111012
Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E824-31
pubmed: 20086201
Nature. 2015 Jan 15;517(7534):293-301
pubmed: 25592534
PLoS One. 2013 Sep 30;8(9):e75147
pubmed: 24098682
Cell Metab. 2022 Oct 4;34(10):1499-1513.e8
pubmed: 36070756
Am J Physiol Cell Physiol. 2018 Sep 1;315(3):C319-C329
pubmed: 29768045
Science. 2019 Mar 1;363(6430):989-993
pubmed: 30819964
Cell Metab. 2009 Nov;10(5):419-29
pubmed: 19883619
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6254-E6263
pubmed: 29891687
J Clin Invest. 2003 Dec;112(12):1796-808
pubmed: 14679176
J Clin Invest. 2006 Jan;116(1):115-24
pubmed: 16341265
Cell. 2015 Jan 15;160(1-2):74-87
pubmed: 25543153
J Clin Invest. 2011 Jun;121(6):2111-7
pubmed: 21633179
J Clin Invest. 2017 Jan 3;127(1):55-64
pubmed: 28045404