Unusual Presentation of an Uncommon Malignancy: A 74-Year-Old Woman with Aggressive Fibromatosis of the Large Intestine Presenting as a Liver Mass and the Therapeutic Management.


Journal

The American journal of case reports
ISSN: 1941-5923
Titre abrégé: Am J Case Rep
Pays: United States
ID NLM: 101489566

Informations de publication

Date de publication:
09 Oct 2023
Historique:
medline: 23 10 2023
pubmed: 9 10 2023
entrez: 9 10 2023
Statut: epublish

Résumé

BACKGROUND Desmoid tumors are a fibroblastic proliferation of soft tissues, with an extreme inclination for local dissemination and recurrence. Surgical excision is the usual treatment choice, with data regarding pharmaceutical treatment being scarce. CASE REPORT A 74-year-old female patient was admitted to "Laikon" General Hospital of Athens, Greece presenting with acute kidney injury secondary to diarrhea. The ultrasound, CT, and abdominal MRI performed showed a 12×6×10 cm tumorous liver lesion. Biopsy of the lesion revealed loosely organized, mesenchymal tissue with spindle cells, and myxoid stroma. Immunochemistry was positive for SMA and b-catenin. Right hemicolectomy was performed with tumor-free surgical margins (R0 resection) and tamoxifen was initiated. Six months after the last MRI (3 months after the use of tamoxifen), a follow-up MRI was performed. The tumor had increased to 14.2×11×12.3 cm, and at the next follow-up it had grown to 20.3×19 cm maximal dimensions; no new metastases were found. The patient received sorafenib and pazopanib. Our patient had PFS with sorafenib for more than 2 years and remained in a good performance status (ECOG 1). For Pazopanid, the median PFS for this treatment option was 6.5 months. CONCLUSIONS The results were good and show a promising method for the treatment of this rare but severe malignancy.

Identifiants

pubmed: 37812585
pii: 939862
doi: 10.12659/AJCR.939862
pmc: PMC10578500
doi:

Substances chimiques

Sorafenib 9ZOQ3TZI87
Tamoxifen 094ZI81Y45

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e939862

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Auteurs

Christos Vallilas (C)

Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Stavros P Papadakos (SP)

Department of Gastroenterology, General Hospital of Athens "Laiko" Medical School of National and Kapodistrian University of Athens, Athens, Greece.

Theodoros Androutsakos (T)

Department of Pathophysiology, "Laikon" General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Alexandros Pergaris (A)

First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Panagiotis Sarantis (P)

Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Eirini A Apostolidi (EA)

Department of Pathophysiology, "Laikon" General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

John Griniatsos (J)

First Department of Surgery, Laiko Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

Michalis V Karamouzis (MV)

Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Stavros Sougioultzis (S)

Department of Pathophysiology, "Laikon" General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

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