Novel T cell/organoid culture system allows
GvHD
allogeneic hematopoietic stem cell transplantation
alloreactive T cell
epithelial cell death
ex vivo model
graft-versus-host disease
intestinal organoids
intraepithelial lymphocytes
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
05
07
2023
accepted:
14
08
2023
medline:
15
9
2023
pubmed:
14
9
2023
entrez:
14
9
2023
Statut:
epublish
Résumé
Acute graft-versus-host disease (GvHD) remains the biggest clinical challenge and prognosis-determining complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Donor T cells are acceptedly key mediators of alloreactivity against host tissues and here especially the gut. In support of previous studies, we found that the intestinal intra-epithelial lymphocyte (IEL) compartment was dynamically regulated in the course of MHC class I full mismatch allo-HSCT. However, while intestinal epithelial cell (IEC) damage endangers the integrity of the intestinal barrier and is a core signature of intestinal GvHD, the question whether and to what degree IELs are contributing to IEC dysregulation is poorly understood. To study lymphoepithelial interaction, we employed a novel
Identifiants
pubmed: 37705975
doi: 10.3389/fimmu.2023.1253514
pmc: PMC10495981
doi:
Substances chimiques
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1253514Informations de copyright
Copyright © 2023 Matthe, Dinkel, Schmid, Vogler, Neurath, Poeck, Neufert, Büttner-Herold and Hildner.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Biol Blood Marrow Transplant. 2016 Jan;22(1):4-10
pubmed: 26386318
Nature. 2009 May 14;459(7244):262-5
pubmed: 19329995
Nat Rev Immunol. 2016 Feb;16(2):79-89
pubmed: 26688350
Science. 2016 Jun 24;352(6293):1581-6
pubmed: 27256884
Immunity. 2019 Jul 16;51(1):90-103.e3
pubmed: 31278057
J Gastroenterol. 2016 Mar;51(3):206-13
pubmed: 26800996
Cell Mol Immunol. 2009 Feb;6(1):15-25
pubmed: 19254476
Eur J Immunol. 1994 Mar;24(3):709-15
pubmed: 7907297
Nat Rev Immunol. 2003 Feb;3(2):147-58
pubmed: 12563298
Front Immunol. 2019 Aug 22;10:1997
pubmed: 31507601
Methods. 2017 Feb 15;115:80-90
pubmed: 27713081
Int Immunol. 1996 Nov;8(11):1767-77
pubmed: 8943572
Immunol Allergy Clin North Am. 2010 Feb;30(1):75-101
pubmed: 20113888
N Engl J Med. 2017 Nov 30;377(22):2167-2179
pubmed: 29171820
Sci Transl Med. 2021 Jan 13;13(576):
pubmed: 33441422
Sci Immunol. 2019 Dec 6;4(42):
pubmed: 31811055
Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):119-127
pubmed: 27913470
J Exp Med. 1975 Jul 1;142(1):212-23
pubmed: 1056976
Front Immunol. 2021 Aug 27;12:713631
pubmed: 34512636
Mucosal Immunol. 2022 Apr;15(4):605-619
pubmed: 35654837
Eur J Immunol. 2022 Oct;52(10):1547-1560
pubmed: 35985020
Gastroenterology. 2009 Jul;137(1):15-7
pubmed: 19450592
J Exp Med. 2005 May 16;201(10):1647-57
pubmed: 15897278
Blood. 2010 Sep 9;116(10):1726-33
pubmed: 20519625
J Exp Med. 2010 Mar 15;207(3):553-64
pubmed: 20156972
Scand J Immunol. 2005 May;61(5):398-409
pubmed: 15882431
J Clin Invest. 2021 Nov 1;131(21):
pubmed: 34720090
Nat Rev Immunol. 2011 Jun 17;11(7):445-56
pubmed: 21681197
Biol Blood Marrow Transplant. 2007 Dec;13(12):1469-76
pubmed: 18022577
Nat Rev Immunol. 2007 Dec;7(12):942-53
pubmed: 18007679
Ann Hematol. 2013 Apr;92(4):497-504
pubmed: 23180439
Nat Methods. 2019 Apr;16(4):278-280
pubmed: 30886414
Biotechniques. 2019 Jul;67(1):23-28
pubmed: 31218886
JCI Insight. 2018 Sep 20;3(18):
pubmed: 30232288
Front Immunol. 2022 Nov 10;13:1008456
pubmed: 36439157
Nature. 2023 Jan;613(7945):743-750
pubmed: 36631610
Blood Adv. 2019 Nov 12;3(21):3436-3448
pubmed: 31714966
J Immunol. 2005 Dec 15;175(12):8003-10
pubmed: 16339537
Nat Rev Gastroenterol Hepatol. 2017 Dec;14(12):711-726
pubmed: 28951581
Cell Transplant. 2020 Jan-Dec;29:963689720966980
pubmed: 33073597
Nature. 2007 Oct 25;449(7165):1003-7
pubmed: 17934449
Int J Mol Sci. 2021 May 13;22(10):
pubmed: 34067987
PLoS One. 2011;6(7):e21968
pubmed: 21779359
Front Immunol. 2018 Jul 30;9:1770
pubmed: 30131803
Front Immunol. 2018 May 25;9:1138
pubmed: 29910804
Biol Blood Marrow Transplant. 2010 Sep;16(9):1309-14
pubmed: 20353832
J Immunol Methods. 2015 Jun;421:89-95
pubmed: 25841547
J Clin Invest. 2018 Mar 1;128(3):916-930
pubmed: 29376889
J Cell Biol. 2010 May 31;189(5):777-82
pubmed: 20513764
Blood. 2009 Apr 9;113(15):3612-9
pubmed: 19211507
Blood. 2020 Jun 25;135(26):2388-2401
pubmed: 32232483
J Leukoc Biol. 2021 Feb;109(2):339-347
pubmed: 32678936
Curr Transplant Rep. 2016;3(4):275-283
pubmed: 27909647
Transplantation. 1995 Jan 27;59(2):268-73
pubmed: 7839451
Nat Rev Immunol. 2018 Aug;18(8):514-525
pubmed: 29717233
Science. 1984 Jul 27;225(4660):429-30
pubmed: 6429853
Curr Opin Immunol. 1995 Jun;7(3):333-42
pubmed: 7546397
Nat Immunol. 2016 Sep 20;17(10):1235
pubmed: 27648549