Protein compactness and interaction valency define the architecture of a biomolecular condensate across scales.

Biomolecular Condensates Fungal Proteins Entropy Fractals Molecular Dynamics Simulation
Large1 S. cerevisiae biomolecular condensate colloid disordered protein fractal cluster liquid-liquid phase separation molecular biophysics physics of living systems structural biology

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
20 07 2023
Historique:
received: 06 05 2022
accepted: 18 07 2023
medline: 8 8 2023
pubmed: 20 7 2023
entrez: 20 7 2023
Statut: epublish

Résumé

Non-membrane-bound biomolecular condensates have been proposed to represent an important mode of subcellular organization in diverse biological settings. However, the fundamental principles governing the spatial organization and dynamics of condensates at the atomistic level remain unclear. The

Identifiants

DOI: 10.7554/eLife.80038 PMID: 37470705 PMC: PMC10406433
pubmed: 37470705
doi: 10.7554/eLife.80038
pii: 80038
pmc: PMC10406433
doi:
pii:

Substances chimiques

Fungal Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Austrian Science Fund FWF
ID : P 30550
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : P 30680-B21
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : F79
Pays : Austria

Informations de copyright

© 2023, Polyansky, Gallego et al.

Déclaration de conflit d'intérêts

AP, LG, RE, AK, BZ No competing interests declared

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Auteurs

Anton A Polyansky (AA)

Max Perutz Labs, Vienna Biocenter Campus (VBC), Vienna, Austria.
University of Vienna, Center for Molecular Biology, Department of Structural and Computational Biology, Vienna, Austria.
ORCID: 0000-0002-1011-2706

Laura D Gallego (LD)

Max Perutz Labs, Vienna Biocenter Campus (VBC), Vienna, Austria.
Medical University of Vienna, Center for Medical Biochemistry, Vienna, Austria.

Roman G Efremov (RG)

MM Shemyakin and Yu A Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation.

Alwin Köhler (A)

Max Perutz Labs, Vienna Biocenter Campus (VBC), Vienna, Austria.
Medical University of Vienna, Center for Medical Biochemistry, Vienna, Austria.
University of Vienna, Center for Molecular Biology, Department of Biochemistry and Cell Biology, Vienna, Austria.

Bojan Zagrovic (B)

Max Perutz Labs, Vienna Biocenter Campus (VBC), Vienna, Austria.
University of Vienna, Center for Molecular Biology, Department of Structural and Computational Biology, Vienna, Austria.

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Classifications MeSH

Recherchemedicale.com › Cellules › Structures cellulaires › Condensats biomoléculaires › Protein compactness and interaction valency...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protein compactness and interaction valency...
Recherchemedicale.com › Phénomènes physiques › Thermodynamique › Entropie › Protein compactness and interaction valency...
Recherchemedicale.com › Concepts mathématiques › Fractales › Protein compactness and interaction valency...
Recherchemedicale.com › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Protein compactness and interaction valency...