Chronic Granulomatous Disease: a Cohort of 173 Patients-10-Years Single Center Experience from Egypt.
AR-CGD
Autoimmune manifestations in CGD
CGD in Egypt
Infections in CGD
X-linked CGD
Journal
Journal of clinical immunology
ISSN: 1573-2592
Titre abrégé: J Clin Immunol
Pays: Netherlands
ID NLM: 8102137
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
21
02
2023
accepted:
19
06
2023
medline:
21
11
2023
pubmed:
12
7
2023
entrez:
11
7
2023
Statut:
ppublish
Résumé
Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disorder of phagocytes, characterized by recurrent fungal and bacterial infections. Our aim is to describe the different clinical presentations, non-infectious auto-inflammatory features, types and sites of infections, and to estimate the mortality among our large cohort. This is a retrospective study conducted at the Pediatric Department of Cairo University Children's Hospital in Egypt, including cases with a confirmed CGD diagnosis. One hundred seventy-three confirmed CGD patients were included. AR-CGD was diagnosed in 132 patients (76.3%) including 83 patients (48%) with p47 AR-CGD is predominant in Egypt; CGD must always be ruled out in any patient presenting with typical or atypical mycobacterial or BCG-disease.
Identifiants
pubmed: 37433991
doi: 10.1007/s10875-023-01541-4
pii: 10.1007/s10875-023-01541-4
pmc: PMC10661789
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1799-1811Informations de copyright
© 2023. The Author(s).
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