Effects of multi-organ crosstalk on the physiology and pathology of adipose tissue.
adipocyte
adipose tissue
crosstalk
diabetes
obesity
organs
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
04
2023
accepted:
26
05
2023
medline:
3
7
2023
pubmed:
29
6
2023
entrez:
29
6
2023
Statut:
epublish
Résumé
In previous studies, adipocytes were found to play an important role in regulating whole-body nutrition and energy balance, and are also important in energy metabolism, hormone secretion, and immune regulation. Different adipocytes have different contributions to the body, with white adipocytes primarily storing energy and brown adipocytes producing heat. Recently discovered beige adipocytes, which have characteristics in between white and brown adipocytes, also have the potential to produce heat. Adipocytes interact with other cells in the microenvironment to promote blood vessel growth and immune and neural network interactions. Adipose tissue plays an important role in obesity, metabolic syndrome, and type 2 diabetes. Dysfunction in adipose tissue endocrine and immune regulation can cause and promote the occurrence and development of related diseases. Adipose tissue can also secrete multiple cytokines, which can interact with organs; however, previous studies have not comprehensively summarized the interaction between adipose tissue and other organs. This article reviews the effect of multi-organ crosstalk on the physiology and pathology of adipose tissue, including interactions between the central nervous system, heart, liver, skeletal muscle, and intestines, as well as the mechanisms of adipose tissue in the development of various diseases and its role in disease treatment. It emphasizes the importance of a deeper understanding of these mechanisms for the prevention and treatment of related diseases. Determining these mechanisms has enormous potential for identifying new targets for treating diabetes, metabolic disorders, and cardiovascular diseases.
Identifiants
pubmed: 37383400
doi: 10.3389/fendo.2023.1198984
pmc: PMC10293893
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1198984Informations de copyright
Copyright © 2023 Wang, Liu, Chen, He, Ma, Liu and Sun.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cell Metab. 2013 Oct 1;18(4):478-89
pubmed: 24035587
Cell Metab. 2018 May 01;27(5):1111-1120.e3
pubmed: 29719226
Int J Cardiol. 2019 Mar 1;278:254-260
pubmed: 30297191
Cell Metab. 2016 Feb 9;23(2):350-9
pubmed: 26626462
JCI Insight. 2019 Jun 25;5:
pubmed: 31237863
J Neurosci. 2009 May 6;29(18):5916-25
pubmed: 19420258
Biosci Biotechnol Biochem. 2007 Feb;71(2):380-9
pubmed: 17284861
J Am Coll Cardiol. 2020 Sep 8;76(10):1197-1211
pubmed: 32883413
Curr Opin Clin Nutr Metab Care. 2018 Nov;21(6):437-443
pubmed: 30148740
Nat Med. 2015 Dec;21(12):1497-1501
pubmed: 26569380
Exp Clin Endocrinol Diabetes. 1997;105 Suppl 2:38-40
pubmed: 9288542
Sci Transl Med. 2020 Aug 26;12(558):
pubmed: 32848096
Diabetes. 2013 May;62(5):1537-46
pubmed: 23321073
Theranostics. 2018 Mar 8;8(8):2171-2188
pubmed: 29721071
Nature. 2017 Feb 23;542(7642):450-455
pubmed: 28199304
Nat Metab. 2020 May;2(5):397-412
pubmed: 32440655
Nat Metab. 2021 Nov;3(11):1536-1551
pubmed: 34782792
BMC Med Genet. 2016 Sep 05;17(1):63
pubmed: 27596100
Nat Rev Neurosci. 2018 Apr;19(4):185-196
pubmed: 29467468
Cell Metab. 2010 Apr 7;11(4):273-85
pubmed: 20374960
Cell. 2015 Jan 15;160(1-2):88-104
pubmed: 25594176
Proc Natl Acad Sci U S A. 2001 May 22;98(11):6494-9
pubmed: 11371650
Cell Metab. 2015 Aug 4;22(2):279-90
pubmed: 26166748
Cell. 2014 Jun 5;157(6):1279-1291
pubmed: 24906147
Cell Rep. 2018 Oct 9;25(2):413-423.e5
pubmed: 30304681
J Endocrinol. 2019 May 10;241(3):R97-R109
pubmed: 31144796
Nat Rev Endocrinol. 2014 Apr;10(4):193-4
pubmed: 24492182
Nature. 2006 Jan 26;439(7075):484-9
pubmed: 16400329
Nat Med. 2018 Jun;24(6):814-822
pubmed: 29785025
J Biol Chem. 2001 Sep 7;276(36):33336-44
pubmed: 11431482
Curr Opin Clin Nutr Metab Care. 2012 Nov;15(6):547-52
pubmed: 23037904
Diabetes. 2016 May;65(5):1410-23
pubmed: 26936964
Cell Metab. 2016 Jul 12;24(1):130-41
pubmed: 27411014
J Proteome Res. 2012 Feb 3;11(2):620-30
pubmed: 22053906
Cardiovasc Diabetol. 2014 Feb 20;13:47
pubmed: 24552349
Obes Rev. 2020 Dec;21(12):e13085
pubmed: 32608573
Sci Rep. 2015 Jul 10;5:12067
pubmed: 26159457
Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E977-86
pubmed: 19458063
Int J Obes (Lond). 2015 Mar;39(3):397-407
pubmed: 25199621
Cell Rep. 2019 Mar 5;26(10):2720-2737.e5
pubmed: 30840893
J Neurosci Res. 2018 May;96(5):911-920
pubmed: 29098710
Biosci Rep. 2017 Sep 27;37(5):
pubmed: 28831023
Trends Endocrinol Metab. 2014 Jul;25(7):348-55
pubmed: 24746980
Endocrinology. 1996 Feb;137(2):495-503
pubmed: 8593794
Front Endocrinol (Lausanne). 2020 Jul 28;11:498
pubmed: 32849287
Obes Rev. 2020 Feb;21(2):e12958
pubmed: 31777187
Surg Obes Relat Dis. 2018 Nov;14(11):1755-1763
pubmed: 30193906
Cell Death Differ. 2003 Jul;10(7):757-60
pubmed: 12815458
Cell Metab. 2017 Nov 7;26(5):801
pubmed: 29117546
Comp Biochem Physiol Comp Physiol. 1994 Feb;107(2):381-8
pubmed: 7907965
Front Endocrinol (Lausanne). 2012 Jan 03;2:102
pubmed: 22654837
Nat Rev Endocrinol. 2021 Dec;17(12):726-744
pubmed: 34625737
Diabetes. 2012 Nov;61(11):2753-62
pubmed: 22933116
Front Neuroendocrinol. 2014 Oct;35(4):473-93
pubmed: 24736043
Gerontology. 2012;58(1):15-23
pubmed: 21135534
Biochem Pharmacol. 2021 Oct;192:114723
pubmed: 34364887
Curr Opin Pharmacol. 2020 Jun;52:1-8
pubmed: 32387807
Nat Commun. 2018 Nov 26;9(1):4974
pubmed: 30478315
Am J Physiol Cell Physiol. 2021 Mar 1;320(3):C375-C391
pubmed: 33356944
Liver Int. 2020 Sep;40(9):2074-2075
pubmed: 32930522
Nat Med. 2013 Oct;19(10):1338-44
pubmed: 23995282
Nat Rev Cardiol. 2019 Feb;16(2):83-99
pubmed: 30287946
Obesity (Silver Spring). 2016 Mar;24(3):597-605
pubmed: 26916240
Am J Physiol Regul Integr Comp Physiol. 2004 Sep;287(3):R608-11
pubmed: 15155279
Diabetes. 2007 May;56(5):1369-75
pubmed: 17287467
Semin Nucl Med. 2007 May;37(3):195-205
pubmed: 17418152
J Clin Invest. 2012 Mar;122(3):1022-36
pubmed: 22307324
Cell. 2014 Jun 5;157(6):1292-1308
pubmed: 24906148
Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9474-E9482
pubmed: 29078316
Physiol Rev. 2004 Jan;84(1):277-359
pubmed: 14715917
Nat Med. 2021 Jan;27(1):58-65
pubmed: 33398160
J Mol Cell Biol. 2016 Apr;8(2):93-100
pubmed: 26993047
Circulation. 2021 Jan 12;143(2):145-159
pubmed: 33106031
Diabetes. 2006 Sep;55(9):2562-70
pubmed: 16936205
J Clin Invest. 2019 Oct 1;129(10):4050-4057
pubmed: 31573550
PLoS One. 2014 Jan 08;9(1):e84910
pubmed: 24416310
Cell Metab. 2016 Jun 14;23(6):1216-1223
pubmed: 27304513
Cell. 2007 Oct 19;131(2):242-56
pubmed: 17956727
Nature. 1983 Nov 10-16;306(5939):174-6
pubmed: 6316142
Nat Rev Endocrinol. 2019 Apr;15(4):207-225
pubmed: 30733616
Horm Mol Biol Clin Investig. 2017 Jan 18;31(1):
pubmed: 28099124
Obesity (Silver Spring). 2008 Sep;16(9):2053-67
pubmed: 19186330
J Clin Endocrinol Metab. 2020 Apr 1;105(4):
pubmed: 31867674
PLoS One. 2019 Jul 31;14(7):e0220310
pubmed: 31365569
Trends Endocrinol Metab. 2018 Mar;29(3):191-200
pubmed: 29366777
Front Aging Neurosci. 2021 Apr 16;13:649929
pubmed: 33935687
Diabetes. 2012 May;61(5):1122-32
pubmed: 22517657
Cell Metab. 2018 Sep 4;28(3):476-489.e5
pubmed: 30017353
Cell Metab. 2020 Aug 4;32(2):287-300.e7
pubmed: 32755608
Cell Metab. 2009 Jan 7;9(1):99-109
pubmed: 19117550
Methods Mol Biol. 2008;456:1-22
pubmed: 18516549
Cell Metab. 2018 Nov 6;28(5):750-763.e6
pubmed: 30122557
J Biol Chem. 2009 Jan 9;284(2):1279-90
pubmed: 18990699
J Mol Cell Cardiol. 2015 Jul;84:202-11
pubmed: 25968336
Cytokine. 2021 Feb;138:155374
pubmed: 33271386
Cell Rep. 2019 May 7;27(6):1686-1698.e5
pubmed: 31067456
J Clin Invest. 2019 Mar 19;129(6):2305-2317
pubmed: 30888335
Stem Cell Reports. 2015 Oct 13;5(4):569-81
pubmed: 26365511
J Am Coll Cardiol. 2018 May 22;71(20):2360-2372
pubmed: 29773163
iScience. 2019 Jan 25;11:425-439
pubmed: 30661000
Gut. 2020 Jul;69(7):1239-1247
pubmed: 31744910
Diabetologia. 2013 Oct;56(10):2275-85
pubmed: 23868745
Cell Metab. 2015 Jan 6;21(1):33-8
pubmed: 25565203
Cell Metab. 2017 Feb 7;25(2):438-447
pubmed: 28089568
Cell Metab. 2010 Mar 3;11(3):206-12
pubmed: 20197053
Nat Med. 2002 Nov;8(11):1288-95
pubmed: 12368907
Endocrine. 2018 Feb;59(2):260-274
pubmed: 29170905
Nat Med. 2010 Sep;16(9):1001-8
pubmed: 20802499
Front Endocrinol (Lausanne). 2021 Jul 09;12:694162
pubmed: 34305816
Cell Metab. 2012 Sep 5;16(3):394-406
pubmed: 22958922
Trends Mol Med. 2013 Jul;19(7):418-27
pubmed: 23707189
Nutrients. 2019 Sep 06;11(9):
pubmed: 31500090
J Am Coll Cardiol. 2021 Oct 26;78(17):1730-1745
pubmed: 34674819
Cell Metab. 2011 Sep 7;14(3):324-38
pubmed: 21907139
J Intern Med. 2018 Nov;284(5):492-504
pubmed: 29923291
Cell. 2018 Nov 29;175(6):1561-1574.e12
pubmed: 30449620
Nutr Metab (Lond). 2014 Jun 10;11:27
pubmed: 24959194
Cytokine. 2016 Jan;77:107-14
pubmed: 26556104
Diabetes. 2008 Feb;57(2):378-86
pubmed: 18025413
Metabolism. 2021 Jan;114:154429
pubmed: 33166579
Nature. 2019 May;569(7755):229-235
pubmed: 31043739
J Clin Invest. 2019 Oct 1;129(10):4032-4040
pubmed: 31498150
Cell Metab. 2018 Oct 2;28(4):631-643.e3
pubmed: 30078553
Obesity (Silver Spring). 2015 Mar;23(3):602-7
pubmed: 25612068
Front Immunol. 2019 Jul 17;10:1587
pubmed: 31379820
Exp Cell Res. 2021 Jul 15;404(2):112647
pubmed: 34015313
Cell Metab. 2017 Sep 5;26(3):509-522.e6
pubmed: 28877455
FEBS Lett. 2006 Oct 16;580(24):5765-71
pubmed: 17022980
Nat Rev Endocrinol. 2017 Jan;13(1):26-35
pubmed: 27616452
Nat Med. 2014 Dec;20(12):1436-1443
pubmed: 25401691
Nature. 2010 Apr 8;464(7290):917-21
pubmed: 20228789
PLoS One. 2017 Dec 18;12(12):e0189301
pubmed: 29253016
Exp Clin Endocrinol Diabetes. 2020 Jun;128(6-07):446-449
pubmed: 31698480
Diabetes. 2014 Nov;63(11):3686-98
pubmed: 24954193
Mol Metab. 2019 Jun;24:139-148
pubmed: 31003943
Biomolecules. 2021 Dec 19;11(12):
pubmed: 34944549
Cell Metab. 2016 May 10;23(5):770-84
pubmed: 27166942
Nat Commun. 2018 Jan 16;9(1):245
pubmed: 29339725
Diabetes. 2014 Oct;63(10):3346-58
pubmed: 24917578