Transforming an esterase into an enantioselective catecholase through bioconjugation of a versatile metal-chelating inhibitor.
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
01 Aug 2023
01 Aug 2023
Historique:
medline:
2
8
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Metal complexes introduced into protein scaffolds can generate versatile biomimetic catalysts endowed with a variety of catalytic properties. Here, we synthesized and covalently bound a bipyridinyl derivative to the active centre of an esterase to generate a biomimetic catalyst that shows catecholase activity and enantioselective catalytic oxidation of (+)-catechin.
Substances chimiques
Esterases
EC 3.1.-
Coordination Complexes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM