Effects of PmDOME and PmSTAT knockdown on white spot syndrome virus infection in Penaeus monodon.

Animals Penaeidae White spot syndrome virus 1 / physiology Signal Transduction Antiviral Agents / pharmacology

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
17 06 2023
Historique:
received: 07 02 2023
accepted: 15 06 2023
medline: 19 6 2023
pubmed: 18 6 2023
entrez: 17 6 2023
Statut: epublish

Résumé

Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway plays an important role in antiviral immunity. This research reports the full-length DOME receptor gene in Penaeus monodon (PmDOME) and examines the effects of PmDOME and PmSTAT silencing on immune-related gene expressions in shrimp hemocytes during white spot syndrome virus (WSSV) infection. PmDOME and PmSTAT were up-regulated in shrimp hemocytes upon WSSV infection. Suppression of PmDOME and PmSTAT showed significant impacts on the expression levels of ProPO2 (melanization), Vago5 (interferon-like protein) and several antimicrobial peptides, including ALFPm3, Penaeidin3, CrustinPm1 and CrustinPm7. Silencing of PmDOME and PmSTAT reduced WSSV copy numbers and delayed the cumulative mortality caused by WSSV. We postulated that suppression of the JAK/STAT signaling pathway may activate the proPO, IFN-like antiviral cytokine and AMP production, resulting in a delay of WSSV-related mortality.

Identifiants

DOI: 10.1038/s41598-023-37085-1 PMID: 37330617 PMC: PMC10276838
pubmed: 37330617
doi: 10.1038/s41598-023-37085-1
pii: 10.1038/s41598-023-37085-1
pmc: PMC10276838
doi:

Substances chimiques

Antiviral Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9852

Informations de copyright

© 2023. The Author(s).

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Auteurs

Pasunee Laohawutthichai (P)

Center of Excellence in Structural and Computational Biology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Center of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.

Thapanan Jatuyosporn (T)

Center of Excellence in Structural and Computational Biology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Center of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.

Premruethai Supungul (P)

Center of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani, 12120, Thailand.

Anchalee Tassanakajon (A)

Center of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.

Kuakarun Krusong (K)

Center of Excellence in Structural and Computational Biology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand. Kuakarun.k@chula.ac.th.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Effects of PmDOME and PmSTAT knockdown on...
Recherchemedicale.com › Eucaryotes › Animaux › Invertébrés › Arthropodes › Crustacea › Decapoda (crustacea) › Penaeidae › Effects of PmDOME and PmSTAT knockdown on...
Recherchemedicale.com › Virus › Virus à ADN › Nimaviridae › Virus de type 1 du syndrome des taches blanches › Effects of PmDOME and PmSTAT knockdown on...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Transduction du signal › Effects of PmDOME and PmSTAT knockdown on...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Effects of PmDOME and PmSTAT knockdown on...