Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with

Central Nervous System / embryology Embryonic Development Hedgehog Proteins Mechanotransduction, Cellular Neural Tube / embryology YAP-Signaling Proteins Hepatocyte Nuclear Factor 3-beta

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
16 06 2023
Historique:
medline: 16 6 2023
pubmed: 14 6 2023
entrez: 14 6 2023
Statut: ppublish

Résumé

Correct notochord and neural tube (NT) formation is crucial to the development of the central nervous system and midline structures. Integrated biochemical and biophysical signaling controls embryonic growth and patterning; however, the underlying mechanisms remain poorly understood. Here, we took the opportunities of marked morphological changes during notochord and NT formation and identified both necessary and sufficient roles of Yap, a key mechanosensor and mechanotransducer, in biochemical signaling activation during formation of notochord and floor plate, the ventral signaling centers that pattern the dorsal-ventral axis of NT and the surrounding tissues. We showed that Yap activation by a gradient of mechanical stress and tissue stiffness in the notochord and ventral NT induces

Identifiants

DOI: 10.1126/sciadv.adf6927 PMID: 37315133 PMC: PMC10266736
pubmed: 37315133
doi: 10.1126/sciadv.adf6927
pmc: PMC10266736
doi:

Substances chimiques

Hedgehog Proteins 0
YAP-Signaling Proteins 0
Hepatocyte Nuclear Factor 3-beta 135845-92-0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadf6927

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR070877
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE025866
Pays : United States

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Auteurs

Caiqi Cheng (C)

Department of Developmental Biology, Harvard School of Dental Medicine, Harvard Stem Cell Institute, 188 Longwood Ave., Boston, MA 02115, USA.
ORCID: 0009-0006-2865-4171

Qian Cong (Q)

Department of Developmental Biology, Harvard School of Dental Medicine, Harvard Stem Cell Institute, 188 Longwood Ave., Boston, MA 02115, USA.
ORCID: 0000-0002-9493-5784

Yuchen Liu (Y)

Department of Developmental Biology, Harvard School of Dental Medicine, Harvard Stem Cell Institute, 188 Longwood Ave., Boston, MA 02115, USA.
ORCID: 0000-0001-8922-9976

Yizhong Hu (Y)

Department of Developmental Biology, Harvard School of Dental Medicine, Harvard Stem Cell Institute, 188 Longwood Ave., Boston, MA 02115, USA.
ORCID: 0000-0001-9766-1902

Guoyan Liang (G)

Department of Developmental Biology, Harvard School of Dental Medicine, Harvard Stem Cell Institute, 188 Longwood Ave., Boston, MA 02115, USA.

Kevin Marc Manquiquis Dioneda (KMM)

Department of Developmental Biology, Harvard School of Dental Medicine, Harvard Stem Cell Institute, 188 Longwood Ave., Boston, MA 02115, USA.
ORCID: 0000-0002-0120-3171

Yingzi Yang (Y)

Department of Developmental Biology, Harvard School of Dental Medicine, Harvard Stem Cell Institute, 188 Longwood Ave., Boston, MA 02115, USA.
ORCID: 0000-0003-3933-887X

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Classifications MeSH

Recherchemedicale.com › Système nerveux › Système nerveux central › Yap controls notochord formation and neural...
Recherchemedicale.com › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Yap controls notochord formation and neural...
Recherchemedicale.com › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines Hedgehog › Yap controls notochord formation and neural...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Transduction du signal › Mécanotransduction cellulaire › Yap controls notochord formation and neural...
Recherchemedicale.com › Structures de l'embryon › Tube neural › Yap controls notochord formation and neural...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Protéines de signalisation YAP › Yap controls notochord formation and neural...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Facteur nucléaire hépatocytaire HNF-3 bêta › Yap controls notochord formation and neural...