Manufacturing methods, properties, and potential applications in bone tissue regeneration of hydroxyapatite-chitosan biocomposites: A review.


Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
15 Jul 2023
Historique:
received: 15 02 2023
revised: 06 05 2023
accepted: 27 05 2023
medline: 19 6 2023
pubmed: 8 6 2023
entrez: 7 6 2023
Statut: ppublish

Résumé

Hydroxyapatite (HA) and chitosan (CS) biopolymer are the major materials investigated for biomedical purposes. Both of these components play an important role in the orthopedic field as bone substitutes or drug release systems. Used separately, the hydroxyapatite is quite fragile, while CS mechanical strength is very weak. Therefore, a combination of HA and CS polymer is used, which provides excellent mechanical performance with high biocompatibility and biomimetic capacity. Moreover, the porous structure and reactivity of the hydroxyapatite-chitosan (HA-CS) composite allow their application not only as a bone repair but also as a drug delivery system providing controlled drug release directly to the bone site. These features make biomimetic HA-CS composite a subject of interest for many researchers. Through this review, we provide the important recent achievements in the development of HA-CS composites, focusing on manufacturing techniques, conventional and novel three-dimensional bioprinting technology, and physicochemical and biological properties. The drug delivery properties and the most relevant biomedical applications of the HA-CS composite scaffolds are also presented. Finally, alternative approaches are proposed to develop HA composites with the aim to improve their physicochemical, mechanical, and biological properties.

Identifiants

pubmed: 37285882
pii: S0141-8130(23)02044-5
doi: 10.1016/j.ijbiomac.2023.125150
pii:
doi:

Substances chimiques

Chitosan 9012-76-4
Durapatite 91D9GV0Z28
Biocompatible Materials 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

125150

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflict of interest.

Auteurs

H Ait Said (H)

Mohammed VI Polytechnic University (UM6P), High Throughput Multidisciplinary Research laboratory (HTMR-Lab), 43150 Benguerir, Morocco; Cadi Ayyad University, Faculty of Sciences Semlalia (SCIMATOP), Bd Prince My Abdellah, BP 2390, 40000 Marrakech, Morocco.

H Mabroum (H)

Mohammed VI Polytechnic University (UM6P), Faculty of Medical Sciences (FMS), High Institute of Biological and Paramedical Sciences, ISSB-P, Morocco.

M Lahcini (M)

Cadi Ayyad University, Faculty of Sciences and Technologies, IMED Lab, 40000 Marrakech, Morocco.

H Oudadesse (H)

University of Rennes1, ISCR-UMR, 6226 Rennes, France.

A Barroug (A)

Cadi Ayyad University, Faculty of Sciences Semlalia (SCIMATOP), Bd Prince My Abdellah, BP 2390, 40000 Marrakech, Morocco; Mohammed VI Polytechnic University (UM6P), Faculty of Medical Sciences (FMS), High Institute of Biological and Paramedical Sciences, ISSB-P, Morocco.

H Ben Youcef (H)

Mohammed VI Polytechnic University (UM6P), High Throughput Multidisciplinary Research laboratory (HTMR-Lab), 43150 Benguerir, Morocco. Electronic address: hicham.benyoucef@um6p.ma.

H Noukrati (H)

Mohammed VI Polytechnic University (UM6P), Faculty of Medical Sciences (FMS), High Institute of Biological and Paramedical Sciences, ISSB-P, Morocco. Electronic address: hassan.noukrati@um6p.ma.

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