Stem cell-homing biomimetic hydrogel promotes the repair of osteoporotic bone defects through osteogenic and angiogenic coupling.
Animals
Osteogenesis
/ drug effects
Osteoporosis
/ pathology
Mesenchymal Stem Cells
/ metabolism
Humans
Rats
Hydrogels
/ chemistry
Neovascularization, Physiologic
/ drug effects
Biomimetic Materials
/ pharmacology
Nitric Oxide
/ metabolism
Bone Regeneration
/ drug effects
Human Umbilical Vein Endothelial Cells
Disease Models, Animal
Rats, Sprague-Dawley
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
Nov 2024
Nov 2024
Historique:
medline:
2
11
2024
pubmed:
2
11
2024
entrez:
1
11
2024
Statut:
ppublish
Résumé
Osteoporotic bone defects refer to the disruption of bone structural integrity in patients with osteoporosis and pose a substantial challenge to orthopedic surgeons. In this study, we developed a biomimetic hydrogel to improve the osteogenic microenvironment and promote stem cell homing. This hydrogel served as a container for S-nitrosoglutathione and Ca
Identifiants
pubmed: 39485837
doi: 10.1126/sciadv.adq6700
doi:
Substances chimiques
Hydrogels
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM