Collagenous gastritis in children: A national cohort.

Male Female Humans Child Gastritis / complications Biopsy Malabsorption Syndromes / complications Anemia / complications Abdominal Pain / etiology
Anemia Collagenous gastritis Gastritis Pediatric

Journal

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
ISSN: 1769-664X
Titre abrégé: Arch Pediatr
Pays: France
ID NLM: 9421356

Informations de publication

Date de publication:
Jul 2023
Historique:
received: 02 08 2022
revised: 05 02 2023
accepted: 25 03 2023
medline: 26 6 2023
pubmed: 27 5 2023
entrez: 26 5 2023
Statut: ppublish

Résumé

Collagen gastritis is a rare disease that manifests in children mainly as isolated gastric involvement associated with martial deficiency anemia. There are no recommendations for the management and follow-up of these patients. We aimed to describe the clinical data, endoscopic findings, and treatments deployed in France's children with collagenous gastritis. All French pediatric gastroenterology centers and pediatric centers for rare digestive diseases (Centres de Maladies Rares Digestives) were contacted to collect cases of collagenous gastritis, defined on gastric biopsies and diagnosed before 18 years of age. A total of 12 cases diagnosed (4 males and 8 females) between 1995 and 2022 could be analyzed. The median age at diagnosis was 12.5 years (7-15.2). The most frequent clinical presentation was abdominal pain (6/11) and/or nonspecific symptomatology attributed to anemia (8/10). Anemia was present in all children (11/11; Hb 2.8-9.1 g/dL). Nodular gastritis was present in 10 patients (antrum: 2; fundus: 4; in antrum and fundus: 4). All patients had a basement membrane thickening (from 19 to 100 μm). The treatments received were PPI (11), oral or intravenous martial supplementation (12), budesonide (1), and prednisone (1). Martial supplementation improved anemia in all cases. At discontinuation, nine of 10 patients had a recurrence of anemia. Collagenous gastritis is an exceptional condition, clinically manifested in children as abdominal pain and iron deficiency anemia probably of hemorrhagic origin. Patients require long-term follow-up and monitoring of their disease to describe the risk of progression better.

Sections du résumé

BACKGROUND BACKGROUND
Collagen gastritis is a rare disease that manifests in children mainly as isolated gastric involvement associated with martial deficiency anemia. There are no recommendations for the management and follow-up of these patients. We aimed to describe the clinical data, endoscopic findings, and treatments deployed in France's children with collagenous gastritis.
METHODS METHODS
All French pediatric gastroenterology centers and pediatric centers for rare digestive diseases (Centres de Maladies Rares Digestives) were contacted to collect cases of collagenous gastritis, defined on gastric biopsies and diagnosed before 18 years of age.
RESULTS RESULTS
A total of 12 cases diagnosed (4 males and 8 females) between 1995 and 2022 could be analyzed. The median age at diagnosis was 12.5 years (7-15.2). The most frequent clinical presentation was abdominal pain (6/11) and/or nonspecific symptomatology attributed to anemia (8/10). Anemia was present in all children (11/11; Hb 2.8-9.1 g/dL). Nodular gastritis was present in 10 patients (antrum: 2; fundus: 4; in antrum and fundus: 4). All patients had a basement membrane thickening (from 19 to 100 μm). The treatments received were PPI (11), oral or intravenous martial supplementation (12), budesonide (1), and prednisone (1). Martial supplementation improved anemia in all cases. At discontinuation, nine of 10 patients had a recurrence of anemia.
CONCLUSION CONCLUSIONS
Collagenous gastritis is an exceptional condition, clinically manifested in children as abdominal pain and iron deficiency anemia probably of hemorrhagic origin. Patients require long-term follow-up and monitoring of their disease to describe the risk of progression better.

Identifiants

DOI: 10.1016/j.arcped.2023.03.013 PMID: 37236887
pubmed: 37236887
pii: S0929-693X(23)00079-9
doi: 10.1016/j.arcped.2023.03.013
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

307-313

Informations de copyright

Copyright © 2023 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None.

Auteurs

Jonathan Illan Montero (J)

Department of Pediatrics, University Hospital of Vaud (CHUV), 1011 Lausanne, Switzerland. Electronic address: jonathan.illan@chuv.ch.

J Viala (J)

Pediatric Gastroenterology and Nutrition Department, Robert Debré University Hospital, AP-HP, 75019 Paris, France; Paris Cité University, Paris, France.

J Rebeuh (J)

Department of Pediatrics, Strasbourg University Hospital, 67000 Strasbourg, France.

S Berthet (S)

Pediatric Gastroenterology, Saint George Polyclinic, 06105 Nice, France.

R Blais (R)

Department of Pediatrics, Le Mans Hospital, 72037 Le Mans, France.

D Caldari (D)

Department of Pediatric, Mother and Child Hospital, Nantes University Hospital, 44000 Nantes, France.

M Lasfargue (M)

Department of Pediatric, Mother and Child Hospital, Grenoble University Hospital, 38700 Grenoble, France.

G Le Henaff (GL)

Pediatric Gastroenterology, Santé Atlantique-ELSAN Polyclinic, 44800 Saint-Herblain, France.

E Mas (E)

Unité de gastroentérologie, hépatologie, nutrition et diabétologie, hôpital des Enfants, 330, avenue de Grande-Bretagne, TSA 70034, 31300 Toulouse cedex 9, France; Inserm U1043, 31300 Toulouse, France; CNRS, U5282, 31300 Toulouse, France.

N Rustom-Pecciarini (N)

Department of Pediatrics, Annecy Gennevois University Hospital, 74370 Epagny Metz-Tessy, France.

D Berrebi (D)

Paris Cité University, Paris, France; Department of Pediatric Pathology, Robert Debré University and Necker Hospital, AP-HP, 75019 and 75015 Paris, France.

S Henno (S)

Department of Pathology, University Hospital Pontchaillou, 35000 Rennes, France.

A Dabadie (A)

Department of Pediatrics, Rennes South University Hospital, 35200 Rennes, France. Electronic address: alain.dabadie@chu-rennes.fr.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Collagenous gastritis in children: A national cohort.
Recherchemedicale.com › Personnes › Tranches d'âge › Enfant › Collagenous gastritis in children: A national cohort.
Recherchemedicale.com › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies de l'estomac › Gastrite › Collagenous gastritis in children: A national cohort.
Recherchemedicale.com › Techniques d'investigation › Techniques cytologiques › Cytodiagnostic › Biopsie › Collagenous gastritis in children: A national cohort.
Recherchemedicale.com › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Syndromes de malabsorption › Collagenous gastritis in children: A national cohort.
Recherchemedicale.com › Hémopathies et maladies lymphatiques › Hémopathies › Anémie › Collagenous gastritis in children: A national cohort.
Recherchemedicale.com › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes digestifs › Douleur abdominale › Collagenous gastritis in children: A national cohort.