Post-Maturation Reinforcement of 3D-Printed Vascularized Cardiac Tissues.
3D printing
ECM-based hydrogels
biomaterials
cardiac tissue engineering
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
revised:
16
04
2023
received:
09
03
2023
medline:
4
8
2023
pubmed:
24
4
2023
entrez:
24
04
2023
Statut:
ppublish
Résumé
Despite advances in biomaterials engineering, a large gap remains between the weak mechanical properties that can be achieved with natural materials and the strength of synthetic materials. Here, a method is presented for reinforcing an engineered cardiac tissue fabricated from differentiated induced pluripotent stem cells (iPSCs) and an extracellular matrix (ECM)-based hydrogel in a manner that is fully biocompatible. The reinforcement occurs as a post-fabrication step, which allows for the use of 3D-printing technology to generate thick, fully cellularized, and vascularized cardiac tissues. After tissue assembly and during the maturation process in a soft hydrogel, a small, tissue-penetrating reinforcer is deployed, leading to a significant increase in the tissue's mechanical properties. The tissue's robustness is demonstrated by injecting the tissue in a simulated minimally invasive procedure and showing that the tissue is functional and undamaged at the nano-, micro-, and macroscales.
Identifiants
pubmed: 37093760
doi: 10.1002/adma.202302229
doi:
Substances chimiques
Biocompatible Materials
0
Hydrogels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2302229Subventions
Organisme : ERC Starting
ID : 637943
Organisme : ERC Consolidator
ID : 101001242
Organisme : Israel Science Foundation (ISF)
ID : 972/21
Organisme : The Moxie Foundation
Organisme : Nicholas and Elizabeth Slezak Super Center
Informations de copyright
© 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.
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