NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency.

Humans NAD / metabolism Nicotinamide Mononucleotide / metabolism Neurons / metabolism Mitochondria / metabolism Autophagy Niacinamide / metabolism
CP: Cell biology CP: Metabolism NAD NADases NAM NMN NR autophagy cell death cell survival, human embryonic stem cell-derived neurons mitochondria nicotinamide nicotinamide adenine dinucleotide nicotinamide mononucleotide nicotinamide riboside

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
30 05 2023
Historique:
received: 03 03 2022
revised: 22 01 2023
accepted: 23 03 2023
medline: 5 6 2023
pubmed: 22 4 2023
entrez: 22 04 2023
Statut: ppublish

Résumé

Autophagy is a homeostatic process critical for cellular survival, and its malfunction is implicated in human diseases including neurodegeneration. Loss of autophagy contributes to cytotoxicity and tissue degeneration, but the mechanistic understanding of this phenomenon remains elusive. Here, we generated autophagy-deficient (ATG5

Identifiants

DOI: 10.1016/j.celrep.2023.112372 PMID: 37086404 PMC: PMC10556436
pubmed: 37086404
pii: S2211-1247(23)00383-2
doi: 10.1016/j.celrep.2023.112372
pmc: PMC10556436
mid: NIHMS1922107
pii:
doi:

Substances chimiques

NAD 0U46U6E8UK
Nicotinamide Mononucleotide 1094-61-7
Niacinamide 25X51I8RD4

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

112372

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH104610
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107265
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS088538
Pays : United States
Organisme : NICHD NIH HHS
ID : R37 HD045022
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG055549
Pays : United States

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests R.J. is cofounder of Fate Therapeutics, Fulcrum Therapeutics, and Omega Therapeutics and advisor to Dewpoint Therapeutics. E.S. is founder of NMN Bio Ltd. V.I.K. is a scientific advisor for Longaevus Technologies.

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Auteurs

Congxin Sun (C)

Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Elena Seranova (E)

Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Malkiel A Cohen (MA)

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Miruna Chipara (M)

Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Jennie Roberts (J)

Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Dewi Astuti (D)

Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Adina M Palhegyi (AM)

Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Animesh Acharjee (A)

Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham B15 2TT, UK; Institute of Translational Medicine, University Hospitals Birmingham, NHS Foundation Trust, Birmingham B15 2TT, UK; NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospital Birmingham, Birmingham B15 2WB, UK.

Lucia Sedlackova (L)

Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.

Tetsushi Kataura (T)

Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.

Elsje G Otten (EG)

Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.

Prashanta K Panda (PK)

Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Samuel Lara-Reyna (S)

Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK.

Miriam E Korsgen (ME)

Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Kevin J Kauffman (KJ)

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Alejandro Huerta-Uribe (A)

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.

Malgorzata Zatyka (M)

Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Luiz F S E Silva (LFSE)

Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Jorge Torresi (J)

Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Shupei Zhang (S)

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Georgina W Hughes (GW)

Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Carl Ward (C)

Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Erich R Kuechler (ER)

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

David Cartwright (D)

Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Sergey Trushin (S)

Department of Neurology, Mayo Clinic, Rochester, MN 55901, USA.

Eugenia Trushina (E)

Department of Neurology, Mayo Clinic, Rochester, MN 55901, USA.

Gaurav Sahay (G)

Department of Pharmaceutical Sciences and Department of Biomedical Engineering, College of Pharmacy, Oregon State University, Portland, OR 97201, USA.

Yosef Buganim (Y)

Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

Gareth G Lavery (GG)

Department for Biosciences, Nottingham Trent University, Nottingham NG11 8NS, UK.

Joerg Gsponer (J)

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Daniel G Anderson (DG)

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Eva-Maria Frickel (EM)

Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK.

Tatiana R Rosenstock (TR)

Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Timothy Barrett (T)

Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK; Department of Endocrinology, Birmingham Women's and Children's Hospital, Steelehouse Lane, Birmingham B4 6NH, UK.

Oliver D K Maddocks (ODK)

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.

Daniel A Tennant (DA)

Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Haoyi Wang (H)

The State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, China.

Rudolf Jaenisch (R)

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Viktor I Korolchuk (VI)

Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK. Electronic address: viktor.korolchuk@newcastle.ac.uk.

Sovan Sarkar (S)

Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address: s.sarkar@bham.ac.uk.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › NAD depletion mediates cytotoxicity in human...
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › NAD › NAD depletion mediates cytotoxicity in human...
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nicotinamide mononucléotide › NAD depletion mediates cytotoxicity in human...
Recherchemedicale.com › Cellules › Neurones › NAD depletion mediates cytotoxicity in human...
Recherchemedicale.com › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › NAD depletion mediates cytotoxicity in human...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Autophagie › NAD depletion mediates cytotoxicity in human...
Recherchemedicale.com › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Acides nicotiniques › Nicotinamide › NAD depletion mediates cytotoxicity in human...