Respiratory brain impulse propagation in focal epilepsy.

Humans Brain / pathology Epilepsy Seizures Epilepsies, Partial Magnetic Resonance Imaging / methods

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
30 03 2023
Historique:
received: 26 01 2023
accepted: 24 03 2023
medline: 3 4 2023
entrez: 30 3 2023
pubmed: 31 3 2023
Statut: epublish

Résumé

Respiratory brain pulsations pertaining to intra-axial hydrodynamic solute transport are markedly altered in focal epilepsy. We used optical flow analysis of ultra-fast functional magnetic resonance imaging (fMRI) data to investigate the velocity characteristics of respiratory brain impulse propagation in patients with focal epilepsy treated with antiseizure medication (ASM) (medicated patients with focal epilepsy; ME, n = 23), drug-naïve patients with at least one seizure (DN, n = 19) and matched healthy control subjects (HC, n = 75). We detected in the two patient groups (ME and DN) several significant alterations in the respiratory brain pulsation propagation velocity, which showed a bidirectional change dominated by a reduction in speed. Furthermore, the respiratory impulses moved more in reversed or incoherent directions in both patient groups vs. the HC group. The speed reductions and directionality changes occurred in specific phases of the respiratory cycle. In conclusion, irrespective of medication status, both patient groups showed incoherent and slower respiratory brain impulses, which may contribute to epileptic brain pathology by hindering brain hydrodynamics.

Identifiants

DOI: 10.1038/s41598-023-32271-7 PMID: 36997658 PMC: PMC10063583
pubmed: 36997658
doi: 10.1038/s41598-023-32271-7
pii: 10.1038/s41598-023-32271-7
pmc: PMC10063583
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5222

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2023. The Author(s).

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Auteurs

Ahmed Elabasy (A)

Center for Machine Vision and Signal Analysis, University of Oulu, 90014, Oulu, Finland. Ahmed.Elabasy@oulu.fi.
Oulu Functional NeuroImaging, Research Unit of Health Science and Technology, University of Oulu, 90029, Oulu, Finland. Ahmed.Elabasy@oulu.fi.

Mia Suhonen (M)

Diagnostics, Medical Research Center, Oulu University Hospital, 90029, Oulu, Finland. Mia.suhonen@oulu.fi.
Oulu Functional NeuroImaging, Research Unit of Health Science and Technology, University of Oulu, 90029, Oulu, Finland. Mia.suhonen@oulu.fi.

Zalan Rajna (Z)

Center for Machine Vision and Signal Analysis, University of Oulu, 90014, Oulu, Finland.
Oulu Functional NeuroImaging, Research Unit of Health Science and Technology, University of Oulu, 90029, Oulu, Finland.

Youssef Hosni (Y)

Center for Machine Vision and Signal Analysis, University of Oulu, 90014, Oulu, Finland.
Oulu Functional NeuroImaging, Research Unit of Health Science and Technology, University of Oulu, 90029, Oulu, Finland.

Janne Kananen (J)

Diagnostics, Medical Research Center, Oulu University Hospital, 90029, Oulu, Finland.
Oulu Functional NeuroImaging, Research Unit of Health Science and Technology, University of Oulu, 90029, Oulu, Finland.
Clinical Neurophysiology, Research Unit of Health Science and Technology, University of Oulu, 90029, Oulu, Finland.

Johanna Annunen (J)

Research Unit of Clinical Neuroscience, Neurology, University of Oulu, 90029, Oulu, Finland.
Neurocenter (Member of ERN EpiCARE), Medical Research Center, Oulu University Hospital, 90029, Oulu, Finland.

Hanna Ansakorpi (H)

Research Unit of Clinical Neuroscience, Neurology, University of Oulu, 90029, Oulu, Finland.

Vesa Korhonen (V)

Diagnostics, Medical Research Center, Oulu University Hospital, 90029, Oulu, Finland.
Oulu Functional NeuroImaging, Research Unit of Health Science and Technology, University of Oulu, 90029, Oulu, Finland.

Tapio Seppänen (T)

Center for Machine Vision and Signal Analysis, University of Oulu, 90014, Oulu, Finland.

Vesa Kiviniemi (V)

Diagnostics, Medical Research Center, Oulu University Hospital, 90029, Oulu, Finland. vesa.kiviniemi@oulu.fi.
Oulu Functional NeuroImaging, Research Unit of Health Science and Technology, University of Oulu, 90029, Oulu, Finland. vesa.kiviniemi@oulu.fi.
Biocenter Oulu, University of Oulu, 90014, Oulu, Finland. vesa.kiviniemi@oulu.fi.

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Recherchemedicale.com › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Respiratory brain impulse propagation in focal...
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