AAV1.NT-3 gene therapy prevents age-related sarcopenia.

Mice Animals Sarcopenia / genetics Muscle, Skeletal / metabolism Axons / pathology Quality of Life Mice, Inbred C57BL Nerve Regeneration Aging / physiology Genetic Therapy
NT-3 aging gene therapy muscle remodeling sarcopenia

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
09 03 2023
Historique:
received: 22 10 2022
accepted: 02 03 2023
pubmed: 11 3 2023
medline: 24 3 2023
entrez: 10 3 2023
Statut: ppublish

Résumé

Sarcopenia is progressive loss of muscle mass and strength, occurring during normal aging with significant consequences on the quality of life for elderly. Neurotrophin 3 (NT-3) is an important autocrine factor supporting Schwann cell survival and differentiation and stimulating axon regeneration and myelination. NT-3 is involved in the maintenance of neuromuscular junction (NMJ) integrity, restoration of impaired radial growth of muscle fibers through activation of the Akt/mTOR pathway. We tested the efficacy of NT-3 gene transfer therapy in wild type (WT)-aged C57BL/6 mice, a model for natural aging and sarcopenia, via intramuscular injection 1 × 1011 vg AAV1.tMCK.NT-3, at 18 months of age. The treatment efficacy was assessed at 6 months post-injection using run to exhaustion and rotarod tests,

Identifiants

DOI: 10.18632/aging.204577 PMID: 36897179 PMC: PMC10042697
pubmed: 36897179
pii: 204577
doi: 10.18632/aging.204577
pmc: PMC10042697
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1306-1329

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Auteurs

Burcak Ozes (B)

Center for Gene Therapy, The Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH 43205, USA.

Lingying Tong (L)

Center for Gene Therapy, The Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH 43205, USA.

Morgan Myers (M)

Center for Gene Therapy, The Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH 43205, USA.

Kyle Moss (K)

Center for Gene Therapy, The Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH 43205, USA.

Alicia Ridgley (A)

Center for Gene Therapy, The Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH 43205, USA.

Zarife Sahenk (Z)

Center for Gene Therapy, The Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH 43205, USA.
Department of Pediatrics and Neurology, Nationwide Children’s Hospital and The Ohio State University, Columbus, OH 43205, USA.
Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital, Columbus, OH 43205, USA.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › AAV1.NT-3 gene therapy prevents age-related sarcopenia.
Recherchemedicale.com › Eucaryotes › Animaux › AAV1.NT-3 gene therapy prevents age-related sarcopenia.
Recherchemedicale.com › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Manifestations neuromusculaires › Amyotrophie › Sarcopénie › AAV1.NT-3 gene therapy prevents age-related sarcopenia.
Recherchemedicale.com › Tissus › Muscles › Muscle strié › Muscles squelettiques › AAV1.NT-3 gene therapy prevents age-related sarcopenia.
Recherchemedicale.com › Cellules › Neurones › Neurofibres › Axones › AAV1.NT-3 gene therapy prevents age-related sarcopenia.
Recherchemedicale.com › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › AAV1.NT-3 gene therapy prevents age-related sarcopenia.
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › AAV1.NT-3 gene therapy prevents age-related sarcopenia.
Recherchemedicale.com › Phénomènes biologiques › Régénération › Régénération nerveuse › AAV1.NT-3 gene therapy prevents age-related sarcopenia.
Recherchemedicale.com › Phénomènes physiologiques › Croissance et développement › Vieillissement › AAV1.NT-3 gene therapy prevents age-related sarcopenia.
Recherchemedicale.com › Techniques d'investigation › Techniques génétiques › Génie génétique › Thérapie génétique › AAV1.NT-3 gene therapy prevents age-related sarcopenia.