Lipin1 plays complementary roles in myofibre stability and regeneration in dystrophic muscles.
lipin1
membrane integrity
muscle regeneration
necroptosis
skeletal muscle
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
received:
08
11
2022
accepted:
23
01
2023
pmc-release:
01
03
2024
pubmed:
31
1
2023
medline:
4
3
2023
entrez:
30
1
2023
Statut:
ppublish
Résumé
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disorder caused by dystrophin mutations, leading to the loss of sarcolemmal integrity, and resulting in progressive myofibre necrosis and impaired muscle function. Our previous studies suggest that lipin1 is important for skeletal muscle regeneration and myofibre integrity. Additionally, we discovered that mRNA expression levels of lipin1 were significantly reduced in skeletal muscle of DMD patients and the mdx mouse model. To understand the role of lipin1 in dystrophic muscle, we generated dystrophin/lipin1 double knockout (DKO) mice, and compared the limb muscle pathology and function of wild-type B10, muscle-specific lipin1 deficient (lipin1
Identifiants
pubmed: 36715084
doi: 10.1113/JP284085
pmc: PMC9992338
mid: NIHMS1869530
doi:
Substances chimiques
Dystrophin
0
RNA, Messenger
0
Lpin1 protein, mouse
EC 3.1.3.4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
961-978Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR077574
Pays : United States
Organisme : NINDS NIH HHS
ID : R15NS099850
Pays : United States
Organisme : NIH HHS
ID : 5R01AR077574
Pays : United States
Informations de copyright
© 2023 The Authors. The Journal of Physiology © 2023 The Physiological Society.
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