Association of daily physical activity with brain volumes and cervical spinal cord areas in multiple sclerosis.
Fitbit
Multiple sclerosis
activity level
brain MRI
cervical MRI
remote monitoring
spinal cord gray matter area
Journal
Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
pubmed:
28
12
2022
medline:
3
3
2023
entrez:
27
12
2022
Statut:
ppublish
Résumé
Remote activity monitoring has the potential to evaluate real-world, motor function, and disability at home. The relationships of daily physical activity with spinal cord white matter and gray matter (GM) areas, multiple sclerosis (MS) disability and leg function, are unknown. Evaluate the association of structural central nervous system pathology with ambulatory disability. Fifty adults with progressive or relapsing MS with motor disability who could walk >2 minutes were assessed using clinician-evaluated, patient-reported outcomes, and quantitative brain and spinal cord magnetic resonance imaging (MRI) measures. Fitbit Flex2, worn on the non-dominant wrist, remotely assessed activity over 30 days. Univariate and multivariate analyses were performed to assess correlations between physical activity and other disability metrics. Mean age was 53.3 years and median Expanded Disability Status Scale (EDSS) was 4.0. Average daily step counts (STEPS) were highly correlated with EDSS and walking measures. Greater STEPS were significantly correlated with greater C2-C3 spinal cord GM areas (ρ = 0.39, These results provide preliminary evidence that spinal cord GM area is a neuroanatomical substrate associated with STEPS. STEPS could serve as a proxy to alert clinicians and researchers to possible changes in structural nervous system pathology.
Sections du résumé
BACKGROUND
Remote activity monitoring has the potential to evaluate real-world, motor function, and disability at home. The relationships of daily physical activity with spinal cord white matter and gray matter (GM) areas, multiple sclerosis (MS) disability and leg function, are unknown.
OBJECTIVE
Evaluate the association of structural central nervous system pathology with ambulatory disability.
METHODS
Fifty adults with progressive or relapsing MS with motor disability who could walk >2 minutes were assessed using clinician-evaluated, patient-reported outcomes, and quantitative brain and spinal cord magnetic resonance imaging (MRI) measures. Fitbit Flex2, worn on the non-dominant wrist, remotely assessed activity over 30 days. Univariate and multivariate analyses were performed to assess correlations between physical activity and other disability metrics.
RESULTS
Mean age was 53.3 years and median Expanded Disability Status Scale (EDSS) was 4.0. Average daily step counts (STEPS) were highly correlated with EDSS and walking measures. Greater STEPS were significantly correlated with greater C2-C3 spinal cord GM areas (ρ = 0.39,
CONCLUSION
These results provide preliminary evidence that spinal cord GM area is a neuroanatomical substrate associated with STEPS. STEPS could serve as a proxy to alert clinicians and researchers to possible changes in structural nervous system pathology.
Identifiants
pubmed: 36573559
doi: 10.1177/13524585221143726
pmc: PMC9972237
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
363-373Subventions
Organisme : NINDS NIH HHS
ID : R35 NS111644
Pays : United States
Références
Brain Res. 2010 Jun 23;1341:41-51
pubmed: 19560443
J Neuroimaging. 2020 Sep;30(5):598-602
pubmed: 32639671
J Magn Reson Imaging. 2014 Mar;39(3):617-23
pubmed: 23633384
Neurodegener Dis Manag. 2017 Nov;7(6s):35-40
pubmed: 29143590
Ann Neurol. 2014 Oct;76(4):568-80
pubmed: 25087920
J Neuroimaging. 2020 Jan;30(1):110-118
pubmed: 31571307
Mult Scler J Exp Transl Clin. 2020 Dec 07;6(4):2055217320975185
pubmed: 33343919
JAMA Netw Open. 2019 Mar 1;2(3):e190570
pubmed: 30874777
Lancet Neurol. 2005 Oct;4(10):643-52
pubmed: 16168933
J Neurol. 2017 Feb;264(2):316-326
pubmed: 27896433
Brain. 2006 Mar;129(Pt 3):584-94
pubmed: 16401620
Lancet Neurol. 2018 Feb;17(2):162-173
pubmed: 29275977
AJNR Am J Neuroradiol. 2005 Jun-Jul;26(6):1432-8
pubmed: 15956512
Radiology. 2005 Dec;237(3):854-60
pubmed: 16304107
BMC Public Health. 2019 Oct 23;19(1):1354
pubmed: 31646998
Neurology. 2010 Oct 19;75(16):1415-22
pubmed: 20944075
Nat Rev Neurol. 2015 Jun;11(6):327-38
pubmed: 26009002
Ann Neurol. 2011 Feb;69(2):292-302
pubmed: 21387374
Mult Scler Relat Disord. 2020 Jan;37:101426
pubmed: 32172997
Mult Scler Relat Disord. 2015 Jan;4(1):52-7
pubmed: 25787053
JAMA Neurol. 2015 Aug;72(8):897-904
pubmed: 26053119
Neurology. 2011 Jul 19;77(3):257-63
pubmed: 21613600
Mayo Clin Proc. 2020 Jan;95(1):44-56
pubmed: 31902428
PLoS One. 2016 Apr 28;11(4):e0154335
pubmed: 27124611
Ann Neurol. 2016 Oct;80(4):499-510
pubmed: 27464262
Neurology. 1983 Nov;33(11):1444-52
pubmed: 6685237
Lancet Neurol. 2020 Dec;19(12):988-997
pubmed: 33222767
Neurorehabil Neural Repair. 2010 May;24(4):377-83
pubmed: 20019383
Behav Neurol. 2015;2015:482536
pubmed: 26146460
Ann Neurol. 2022 Feb;91(2):268-281
pubmed: 34878197
PLoS One. 2015 Mar 17;10(3):e0118576
pubmed: 25781178
Expert Rev Neurother. 2012 Sep;12(9):1079-88
pubmed: 23039387
Sci Rep. 2020 Apr 29;10(1):7249
pubmed: 32350313
Neurol Clin Pract. 2021 Apr;11(2):e216-e218
pubmed: 33842099
Neuroimage. 2012 Aug 15;62(2):774-81
pubmed: 22248573