Effect of physical activity on the risk of frailty: A systematic review and meta-analysis.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
02
2022
accepted:
13
11
2022
entrez:
1
12
2022
pubmed:
2
12
2022
medline:
6
12
2022
Statut:
epublish
Résumé
The relationship between physical activity (PA) and the risk of frailty has not reached a conclusive result. This systematic review with meta-analysis aimed to evaluate the effect of PA on the onset of frailty in the community-dwelling middle and older age adults by pooling data from cohort studies. A systematic literature search was performed via PubMed, Embase, and Web of Science up to June 01, 2021. Pooled adjusted effect estimates (ES) with 95% confidence interval (CI) were calculated by using the random-effect model and by comparing the highest with lowest levels of PA. Heterogeneity was tested using the I2 statistic and Q-test. The quality of evidence was evaluated by using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. A total of ten cohort studies with 14 records were selected, and the GRADE approach classified the quality of evidence as low. In comparison with the lowest level of PA, the highest level of PA was associated with 41% decreased odds of frailty (ES: 0.59, 95% CI: 0.51-0.67; I2 = 70.0%, P-heterogeneity < 0.001) after pooling results from included studies. In stratified analysis by frailty assessment approach, the highest level of PA was significantly associated with 37% (ES 0.63, 95% CI: 0.52-0.77, 49% (ES: 0.51, 95% CI: 0.41-0.63), and 30% (ES: 0.70, 95% CI: 0.65-0.75) reduced odds of frailty when pooling studies using criteria of physical frailty, multidimensional model, and accumulation of disability, respectively. Stratified analyses further by PA indicators and PA assessment tools yielded similar protective effects in any subgroups. This study with moderate-certainty evidence shows that a higher level of PA was associated with lower odds of frailty, and the benefits of PA for frailty prevention were independent of frailty assessment tools, PA indicators, and PA assessment methods. Findings from this study may help implement active exercise strategies to prevent frailty.
Identifiants
pubmed: 36454790
doi: 10.1371/journal.pone.0278226
pii: PONE-D-22-03407
pmc: PMC9714708
doi:
Types de publication
Meta-Analysis
Systematic Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0278226Informations de copyright
Copyright: © 2022 Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Redox Biol. 2020 Aug;35:101513
pubmed: 32234291
JAMA Netw Open. 2019 Aug 2;2(8):e198398
pubmed: 31373653
Radiat Environ Biophys. 2020 Aug;59(3):415-421
pubmed: 32468176
PLoS One. 2019 Oct 30;14(10):e0223799
pubmed: 31665163
Circulation. 2013 Nov 12;128(20):2259-79
pubmed: 24126387
Br J Sports Med. 2020 Dec;54(24):1451-1462
pubmed: 33239350
Brain Sci. 2017 Feb 20;7(2):
pubmed: 28230730
J Am Med Dir Assoc. 2018 Jun;19(6):480-483
pubmed: 29793675
BMC Geriatr. 2019 Jul 2;19(1):181
pubmed: 31266451
J Am Geriatr Soc. 2012 Aug;60(8):1487-92
pubmed: 22881367
Public Health Nutr. 2021 Dec;24(18):6122-6136
pubmed: 33691824
Bone. 2016 Sep;90:116-22
pubmed: 27321894
Sports Med. 2018 Jun;48(6):1405-1436
pubmed: 29667159
Osteoporos Int. 2014 Apr;25(4):1389-400
pubmed: 24531424
J Gerontol A Biol Sci Med Sci. 2013 Nov;68(11):1433-8
pubmed: 23525478
Lancet. 2013 Mar 2;381(9868):752-62
pubmed: 23395245
J Am Med Dir Assoc. 2015 Nov 1;16(11):940-5
pubmed: 26255709
J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):622-629
pubmed: 29106478
Int J Environ Res Public Health. 2017 Sep 21;14(10):
pubmed: 28934150
Sports Med. 2019 Apr;49(4):509-523
pubmed: 30778851
Age Ageing. 2021 Jan 8;50(1):96-104
pubmed: 33068107
Am J Epidemiol. 2017 Aug 15;186(4):420-434
pubmed: 28633404
Arch Gerontol Geriatr. 2019 Sep - Oct;84:103898
pubmed: 31228673
Ann Oncol. 2015 Jun;26(6):1091-1101
pubmed: 25403592
Int J Cardiol. 2017 Jun 1;236:283-289
pubmed: 28215466
Ageing Res Rev. 2012 Jan;11(1):136-49
pubmed: 22101330
J Phys Act Health. 2020 Aug 11;17(12):1247-1258
pubmed: 32781432
Medicine (Baltimore). 2019 Aug;98(35):e16955
pubmed: 31464936
Age Ageing. 2017 May 1;46(3):383-392
pubmed: 28064173
J Epidemiol Community Health. 2016 Jul;70(7):722-9
pubmed: 26933121
BMJ. 2015 Mar 16;350:h870
pubmed: 25775931
Compr Physiol. 2013 Jan;3(1):1-58
pubmed: 23720280
Am J Cardiol. 2013 Jun 15;111(12):1805-11
pubmed: 23578351
J Frailty Aging. 2020;9(3):144-149
pubmed: 32588028
Lancet. 2019 Oct 12;394(10206):1365-1375
pubmed: 31609228
Rev Esp Cardiol (Engl Ed). 2021 Sep;74(9):790-799
pubmed: 34446261
J Am Med Dir Assoc. 2019 Aug;20(8):1032-1036
pubmed: 30792108
Br J Sports Med. 2020 Aug;54(15):885-891
pubmed: 31792067
J Am Geriatr Soc. 2020 Jul;68(7):1484-1493
pubmed: 32196638
J Am Med Dir Assoc. 2020 May;21(5):710.e1-710.e9
pubmed: 31636035
Ann Epidemiol. 2005 Jan;15(1):44-55
pubmed: 15571993
J Am Med Dir Assoc. 2015 Dec;16(12):1027-33
pubmed: 26255098
Disabil Rehabil. 2017 Sep;39(19):1897-1908
pubmed: 27558741
Ann Intern Med. 2018 Mar 6;168(5):309-316
pubmed: 29310138
J Clin Nurs. 2022 Jan;31(1-2):43-61
pubmed: 34289511
Maturitas. 2020 Jun;136:54-59
pubmed: 32386667
Ageing Res Rev. 2021 May;67:101266
pubmed: 33607291
Med Sci Sports Exerc. 2012 Jul;44(7):1235-42
pubmed: 22246219
Med Sci Sports Exerc. 2010 Sep;42(9):1644-50
pubmed: 20142771
J Aging Res. 2011 Apr 04;2011:569194
pubmed: 21584244
J Gerontol A Biol Sci Med Sci. 2009 Jan;64(1):61-8
pubmed: 19164276
PLoS Med. 2020 Jul 6;17(7):e1003147
pubmed: 32628661
Prev Med. 1997 Nov-Dec;26(6):845-54
pubmed: 9388797
Age Ageing. 2021 Jan 8;50(1):161-168
pubmed: 32808971
Am J Prev Med. 2005 Jan;28(1):9-18
pubmed: 15626550
BMJ. 2003 Sep 6;327(7414):557-60
pubmed: 12958120