Extracellular signals regulate the biogenesis of extracellular vesicles.
Exosome
Extracellular signal
Extracellular vesicle
Information transfer
Microvesicle
Signal transduction
Journal
Biological research
ISSN: 0717-6287
Titre abrégé: Biol Res
Pays: England
ID NLM: 9308271
Informations de publication
Date de publication:
26 Nov 2022
26 Nov 2022
Historique:
received:
20
07
2022
accepted:
15
11
2022
entrez:
26
11
2022
pubmed:
27
11
2022
medline:
30
11
2022
Statut:
epublish
Résumé
Extracellular vesicles (EVs) are naturally released membrane vesicles that act as carriers of proteins and RNAs for intercellular communication. With various biomolecules and specific ligands, EV has represented a novel form of information transfer, which possesses extremely outstanding efficiency and specificity compared to the classical signal transduction. In addition, EV has extended the concept of signal transduction to intercellular aspect by working as the collection of extracellular information. Therefore, the functions of EVs have been extensively characterized and EVs exhibit an exciting prospect for clinical applications. However, the biogenesis of EVs and, in particular, the regulation of this process by extracellular signals, which are essential to conduct further studies and support optimal utility, remain unclear. Here, we review the current understanding of the biogenesis of EVs, focus on the regulation of this process by extracellular signals and discuss their therapeutic value.
Identifiants
pubmed: 36435789
doi: 10.1186/s40659-022-00405-2
pii: 10.1186/s40659-022-00405-2
pmc: PMC9701380
doi:
Substances chimiques
RNA
63231-63-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
35Subventions
Organisme : National Natural Science Foundation of China
ID : 81773112
Organisme : National Natural Science Foundation of China
ID : 82073186
Informations de copyright
© 2022. The Author(s).
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