Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy.

Mice Animals Mitophagy Coumarins / pharmacology Wnt Signaling Pathway Stem Cells Immunologic Memory
T(SCM) anti-tumor immunity mitophagy

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
08 11 2022
Historique:
received: 01 03 2022
revised: 31 07 2022
accepted: 23 09 2022
entrez: 9 11 2022
pubmed: 10 11 2022
medline: 15 11 2022
Statut: ppublish

Résumé

T memory stem cells (T

Identifiants

DOI: 10.1016/j.immuni.2022.09.014 PMID: 36351375
pubmed: 36351375
pii: S1074-7613(22)00508-8
doi: 10.1016/j.immuni.2022.09.014
pii:
doi:

Substances chimiques

3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one 1143-70-0
Coumarins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2059-2073.e8

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors have filed patents regarding the use of Urolithin in tumor therapy and CAR T cell generation. M.D. is an employee of AstraZeneca, UK. C.R. is CEO and a board member of Amazentis SA; P.A.A. is an employee of Vandria SA. F.R.G. has received consulting fees from Amazentis.

Auteurs

Dominic Denk (D)

Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt/Main, Germany; Department of Medicine 1, Goethe-University Hospital Frankfurt, Frankfurt/Main, Germany.

Valentina Petrocelli (V)

Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt/Main, Germany.

Claire Conche (C)

Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt/Main, Germany.

Moritz Drachsler (M)

Department of Medicine 1, Goethe-University Hospital Frankfurt, Frankfurt/Main, Germany.

Paul K Ziegler (PK)

Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Frankfurt/Main, Germany.

Angela Braun (A)

Molecular Biotechnology and Gene Therapy, Paul-Ehrlich Institut, Langen, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Alena Kress (A)

Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt/Main, Germany.

Adele M Nicolas (AM)

Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt/Main, Germany; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596 Frankfurt/Main, Germany.

Kathleen Mohs (K)

Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt/Main, Germany.

Christoph Becker (C)

Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany; Deutsches Zentrum Immuntherapie (DZI), 91054 Erlangen, Germany.

Markus F Neurath (MF)

Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany; Deutsches Zentrum Immuntherapie (DZI), 91054 Erlangen, Germany.

Henner F Farin (HF)

Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt/Main, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596 Frankfurt/Main, Germany.

Christian J Buchholz (CJ)

Molecular Biotechnology and Gene Therapy, Paul-Ehrlich Institut, Langen, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Pénélope A Andreux (PA)

Amazentis SA, EPFL Innovation Park, Lausanne, Switzerland.

Chris Rinsch (C)

Amazentis SA, EPFL Innovation Park, Lausanne, Switzerland.

Florian R Greten (FR)

Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt/Main, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596 Frankfurt/Main, Germany. Electronic address: greten@gsh.uni-frankfurt.de.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Expansion of T memory stem cells with superior...
Recherchemedicale.com › Eucaryotes › Animaux › Expansion of T memory stem cells with superior...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Renouvellement des mitochondries › Dégradation des mitochondries › Expansion of T memory stem cells with superior...
Recherchemedicale.com › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Coumarines › Expansion of T memory stem cells with superior...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Wnt › Expansion of T memory stem cells with superior...
Recherchemedicale.com › Cellules › Cellules souches › Expansion of T memory stem cells with superior...
Recherchemedicale.com › Phénomènes du système immunitaire › Immunité › Immunité acquise › Mémoire immunologique › Expansion of T memory stem cells with superior...