The role of adjuvant therapy in pT4N0 laryngectomized patients: Multicentric observational study.

Humans Laryngeal Neoplasms / surgery Retrospective Studies Neoplasm Staging Laryngectomy / methods Neck Dissection / methods Carcinoma, Squamous Cell / surgery Glottis / surgery Neoplasm Recurrence, Local / pathology
glottis head and neck neoplasms laryngeal neoplasms laryngectomy radiotherapy squamous cell carcinoma of head and neck

Journal

Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541

Informations de publication

Date de publication:
Jan 2023
Historique:
revised: 20 09 2022
received: 09 08 2022
accepted: 04 10 2022
pubmed: 18 10 2022
medline: 15 12 2022
entrez: 17 10 2022
Statut: ppublish

Résumé

To retrospectively evaluate oncological outcomes in two groups of patients with pT4aN0 glottic SCC treated with total laryngectomy (TL) and neck dissection (ND) who underwent postoperative radiotherapy or exclusive clinical and radiological follow-up. It includes patients with pT4N0 glottic SCC who underwent TL and unilateral or bilateral ND with or without PORT. Divided in two comparison groups: the first group underwent adjuvant RT (TL-PORT); the second group referred to clinical and radiological follow-up (TL). PORT was associated with a better OS while no differences were found in terms of DSS. A better local control is achieved when PORT is administered while no differences in terms of regional and distant control rates were found. Bilateral ND positively impacts on the regional control while the PNI negatively impact the regional control. A tailored PORT protocol might be considered for pT4N0 glottic SCC treated with TL and ND, both considering the ND's extent and presence of PNI.

Sections du résumé

BACKGROUND BACKGROUND
To retrospectively evaluate oncological outcomes in two groups of patients with pT4aN0 glottic SCC treated with total laryngectomy (TL) and neck dissection (ND) who underwent postoperative radiotherapy or exclusive clinical and radiological follow-up.
METHODS METHODS
It includes patients with pT4N0 glottic SCC who underwent TL and unilateral or bilateral ND with or without PORT. Divided in two comparison groups: the first group underwent adjuvant RT (TL-PORT); the second group referred to clinical and radiological follow-up (TL).
RESULTS RESULTS
PORT was associated with a better OS while no differences were found in terms of DSS. A better local control is achieved when PORT is administered while no differences in terms of regional and distant control rates were found. Bilateral ND positively impacts on the regional control while the PNI negatively impact the regional control.
CONCLUSIONS CONCLUSIONS
A tailored PORT protocol might be considered for pT4N0 glottic SCC treated with TL and ND, both considering the ND's extent and presence of PNI.

Identifiants

DOI: 10.1002/hed.27225 PMID: 36250285 PMC: PMC10092371
pubmed: 36250285
doi: 10.1002/hed.27225
pmc: PMC10092371
doi:

Types de publication

Observational Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

197-206

Informations de copyright

© 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.

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Auteurs

Francesco Mattioli (F)

Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.

Edoardo Serafini (E)

Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.

Alfredo Lo Manto (A)

Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
ORCID: 0000-0002-2928-2051

Francesca Mularoni (F)

Section of Otorhinolaryngology - Head and Neck Surgery, Department of Neurosciences, University of Padua - Azienda Ospedale Università di Padova, Padua, Italy.

Andi Abeshi (A)

Department of Otorhinolaryngology - Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy.

Marco Lionello (M)

Otorhinolaryngology Unit, Vittorio Veneto Hospital, Vittorio Veneto, Italy.

Marco Ferrari (M)

Section of Otorhinolaryngology - Head and Neck Surgery, Department of Neurosciences, University of Padua - Azienda Ospedale Università di Padova, Padua, Italy.

Alberto Paderno (A)

Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.

Davide Lancini (D)

Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.

Davide Mattavelli (D)

Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
ORCID: 0000-0001-7023-6746

Gennaro Confuorto (G)

Otolaryngology Unit, Department of Surgery, Dentistry and Paediatrics, University of Verona, Verona, Italy.

Filippo Marchi (F)

Department of Otorhinolaryngology - Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
ORCID: 0000-0002-7997-964X

Alessandro Ioppi (A)

Department of Otorhinolaryngology - Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.

Claudio Sampieri (C)

Department of Otorhinolaryngology - Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.

Giuseppe Mercante (G)

Otorhinolaryngology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Armando De Virgilio (A)

Otorhinolaryngology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
ORCID: 0000-0003-0738-8223

Gerardo Petruzzi (G)

Department of Otolaryngology - Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
ORCID: 0000-0003-0371-7667

Erika Crosetti (E)

ENT Unit, Department of Oncology, University of Turin, San Luigi Gonzaga Hospital Orbassano, Turin, Italy.
ORCID: 0000-0003-4340-9677

Raul Pellini (R)

Department of Otolaryngology - Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Spriano Giuseppe (S)

Otorhinolaryngology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Peretti Giorgio (P)

Department of Otorhinolaryngology - Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.

Cesare Piazza (C)

Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
ORCID: 0000-0002-2391-9357

Gabriele Molteni (G)

Otolaryngology Unit, Department of Surgery, Dentistry and Paediatrics, University of Verona, Verona, Italy.
Department of Otolaryngology - Head and Neck Surgery, University Hospital Policlinico, Verona, Italy.
ORCID: 0000-0001-7764-2122

Andy Bertolin (A)

Otorhinolaryngology Unit, Vittorio Veneto Hospital, Vittorio Veneto, Italy.

Giovanni Succo (G)

ENT Unit, San Giovanni Bosco Hospital, Turin, Italy.
ORCID: 0000-0003-0375-6623

Piero Nicolai (P)

Section of Otorhinolaryngology - Head and Neck Surgery, Department of Neurosciences, University of Padua - Azienda Ospedale Università di Padova, Padua, Italy.

Matteo Alicandri-Ciufelli (M)

Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.

Daniele Marchioni (D)

Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.

Livio Presutti (L)

Department of Otorhinolaryngology - Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy.
Department of Specialist, Diagnostic and Experimental Medicine (DIMES), Alma Mater Studiorum, Università di Bologna, Bologna, Italy.

Matteo Fermi (M)

Department of Otorhinolaryngology - Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy.
Department of Specialist, Diagnostic and Experimental Medicine (DIMES), Alma Mater Studiorum, Università di Bologna, Bologna, Italy.
ORCID: 0000-0002-2727-0321

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The role of adjuvant therapy in pT4N0...
Recherchemedicale.com › Maladies oto-rhino-laryngologiques › Tumeurs oto-rhino-laryngologiques › Tumeurs du larynx › The role of adjuvant therapy in pT4N0...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › The role of adjuvant therapy in pT4N0...
Recherchemedicale.com › Diagnostic › Pronostic › Stadification tumorale › The role of adjuvant therapy in pT4N0...
Recherchemedicale.com › Procédures de chirurgie opératoire › Procédures de chirurgie oto-rhino-laryngologique › Laryngectomie › The role of adjuvant therapy in pT4N0...
Recherchemedicale.com › Procédures de chirurgie opératoire › Procédures de chirurgie oto-rhino-laryngologique › Évidement ganglionnaire cervical › The role of adjuvant therapy in pT4N0...
Recherchemedicale.com › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › The role of adjuvant therapy in pT4N0...
Recherchemedicale.com › Appareil respiratoire › Larynx › Glotte › The role of adjuvant therapy in pT4N0...
Recherchemedicale.com › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › The role of adjuvant therapy in pT4N0...