Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions.
NAD
toll-interleukin receptor domain
toll-like receptor
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
14 Jul 2022
14 Jul 2022
Historique:
received:
31
05
2022
revised:
08
07
2022
accepted:
11
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
29
7
2022
Statut:
epublish
Résumé
Toll-interleukin receptor (TIR) domains have emerged as critical players involved in innate immune signaling in humans but are also expressed as potential virulence factors within multiple pathogenic bacteria. However, there has been a shortage of structural studies aimed at elucidating atomic resolution details with respect to their interactions, potentially owing to their dynamic nature. Here, we used a combination of biophysical and biochemical studies to reveal the dynamic behavior and functional interactions of a panel of both bacterial TIR-containing proteins and mammalian receptor TIR domains. Regarding dynamics, all three bacterial TIR domains studied here exhibited an inherent exchange that led to severe resonance line-broadening, revealing their intrinsic dynamic nature on the intermediate NMR timescale. In contrast, the three mammalian TIR domains studied here exhibited a range in terms of their dynamic exchange that spans multiple timescales. Functionally, only the bacterial TIR domains were catalytic towards the cleavage of NAD
Identifiants
pubmed: 35889366
pii: molecules27144494
doi: 10.3390/molecules27144494
pmc: PMC9318647
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Virulence Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R01AI015614
Pays : United States
Organisme : NIH HHS
ID : R21AI146295
Pays : United States
Organisme : NIH HHS
ID : S10 OD021641
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI015614
Pays : United States
Organisme : NIH HHS
ID : R21HL150032
Pays : United States
Organisme : NIH HHS
ID : RM1GM131968
Pays : United States
Organisme : NIH HHS
ID : R56 CA230069
Pays : United States
Organisme : NIH HHS
ID : R01HL149714
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM139892
Pays : United States
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