Discovery of novel gating checkpoints in the Orai1 calcium channel by systematic analysis of constitutively active mutants of its paralogs and orthologs.

Calcium / metabolism Calcium Channels / metabolism Calcium Signaling Humans Mutation / genetics ORAI1 Protein / metabolism Stromal Interaction Molecule 1 / genetics
ANSGA Calcium Orai1 Orai2 Orai3 STIM1

Journal

Cell calcium
ISSN: 1532-1991
Titre abrégé: Cell Calcium
Pays: Netherlands
ID NLM: 8006226

Informations de publication

Date de publication:
07 2022
Historique:
received: 05 05 2022
revised: 17 06 2022
accepted: 20 06 2022
pubmed: 7 7 2022
medline: 19 7 2022
entrez: 6 7 2022
Statut: ppublish

Résumé

In humans, there are three paralogs of the Orai Ca

Identifiants

DOI: 10.1016/j.ceca.2022.102616 PMID: 35792401
pubmed: 35792401
pii: S0143-4160(22)00089-6
doi: 10.1016/j.ceca.2022.102616
pii:
doi:

Substances chimiques

Calcium Channels 0
ORAI1 Protein 0
ORAI1 protein, human 0
Stromal Interaction Molecule 1 0
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102616

Subventions

Organisme : Austrian Science Fund FWF
ID : P 32075
Pays : Austria

Informations de copyright

Copyright © 2022. Published by Elsevier Ltd.

Auteurs

Bartłomiej Augustynek (B)

Membrane Transport Discovery Lab, Department of Nephrology and Hypertension and Department of Biomedical Research, Inselspital, University of Bern, Freiburgstrasse 15, CH-3010 Bern, Switzerland.

Gergely Gyimesi (G)

Membrane Transport Discovery Lab, Department of Nephrology and Hypertension and Department of Biomedical Research, Inselspital, University of Bern, Freiburgstrasse 15, CH-3010 Bern, Switzerland.

Jan Dernič (J)

Membrane Transport Discovery Lab, Department of Nephrology and Hypertension and Department of Biomedical Research, Inselspital, University of Bern, Freiburgstrasse 15, CH-3010 Bern, Switzerland.

Matthias Sallinger (M)

Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.

Giuseppe Albano (G)

Membrane Transport Discovery Lab, Department of Nephrology and Hypertension and Department of Biomedical Research, Inselspital, University of Bern, Freiburgstrasse 15, CH-3010 Bern, Switzerland.

Gabriel J Klesse (GJ)

Membrane Transport Discovery Lab, Department of Nephrology and Hypertension and Department of Biomedical Research, Inselspital, University of Bern, Freiburgstrasse 15, CH-3010 Bern, Switzerland.

Palanivel Kandasamy (P)

Membrane Transport Discovery Lab, Department of Nephrology and Hypertension and Department of Biomedical Research, Inselspital, University of Bern, Freiburgstrasse 15, CH-3010 Bern, Switzerland.

Herwig Grabmayr (H)

Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.

Irene Frischauf (I)

Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.

Daniel G Fuster (DG)

Membrane Transport Discovery Lab, Department of Nephrology and Hypertension and Department of Biomedical Research, Inselspital, University of Bern, Freiburgstrasse 15, CH-3010 Bern, Switzerland.

Christine Peinelt (C)

Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.

Matthias A Hediger (MA)

Membrane Transport Discovery Lab, Department of Nephrology and Hypertension and Department of Biomedical Research, Inselspital, University of Bern, Freiburgstrasse 15, CH-3010 Bern, Switzerland. Electronic address: matthias.hediger@ibmm.unibe.ch.

Rajesh Bhardwaj (R)

Membrane Transport Discovery Lab, Department of Nephrology and Hypertension and Department of Biomedical Research, Inselspital, University of Bern, Freiburgstrasse 15, CH-3010 Bern, Switzerland; Current address: Signal Transduction Laboratory, National Institute of Environmental Health Sciences, NIH, 111 TW Alexander Drive, NC 27709, USA. Electronic address: rajesh.bhardwaj@nih.gov.

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Classifications MeSH

Recherchemedicale.com › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Discovery of novel gating checkpoints in the...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Discovery of novel gating checkpoints in the...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › Discovery of novel gating checkpoints in the...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Discovery of novel gating checkpoints in the...
Recherchemedicale.com › Phénomènes génétiques › Variation génétique › Mutation › Discovery of novel gating checkpoints in the...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canaux calciques activés par la libération de calcium › Protéine ORAI1 › Discovery of novel gating checkpoints in the...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Molécules d'interaction stromale › Molécule-1 d'interaction stromale › Discovery of novel gating checkpoints in the...