Tumor budding and fibrotic focus-proposed grading system for tumor budding in invasive carcinoma no special type of the breast.
Breast cancer
Fibrotic focus
Tumor budding
Tumor cell–stromal cell interaction
Tumor stroma
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
22
10
2021
accepted:
05
05
2022
revised:
18
04
2022
pubmed:
14
6
2022
medline:
4
8
2022
entrez:
13
6
2022
Statut:
ppublish
Résumé
Tumor budding grade is a very useful histological prognostic indicator for colorectal cancer patients. Recently, it has been also reported as a significant prognostic indicator in invasive breast carcinoma patients. Our group and others have previously reported that the presence of a fibrotic focus in the tumor is a very useful histological finding for accurately predicting the prognosis in patients with invasive carcinoma of no special type (ICNST) of the breast. The purpose of the present study was to investigate whether a grading system incorporating tumor budding in a fibrotic focus is superior to the conventional grading system for tumor budding to accurately predict outcomes in patients with ICNST. According to our new grading system, we classified the tumors into grade I (164 cases), grade II (581 cases), and grade III (110 cases), and the results clearly demonstrated the significant superiority of the new grading system over that of conventional tumor budding alone for accurately predicting outcomes in patients with ICNST. Our findings strongly suggest that tumor cells and tumor-stromal cells interaction play very important roles in tumor progression rather than tumor cells alone.
Identifiants
pubmed: 35695928
doi: 10.1007/s00428-022-03337-0
pii: 10.1007/s00428-022-03337-0
pmc: PMC9343319
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
161-190Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s).
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