Protective Effects of

Animals Mice Rats Apoptosis Cardiotoxicity / drug therapy Doxorubicin / toxicity Heme Oxygenase (Decyclizing) / metabolism Heme Oxygenase-1 / metabolism Membrane Proteins / metabolism Mitochondria / metabolism Myocytes, Cardiac / metabolism NF-E2-Related Factor 2 / metabolism Oxidative Stress Polyporaceae Proto-Oncogene Proteins c-akt / metabolism Signal Transduction TOR Serine-Threonine Kinases / metabolism

Journal

Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826

Informations de publication

Date de publication:
2022
Historique:
received: 24 02 2022
revised: 12 04 2022
accepted: 14 05 2022
entrez: 13 6 2022
pubmed: 14 6 2022
medline: 15 6 2022
Statut: epublish

Résumé

Clinical outcomes for doxorubicin (Dox) are limited by its cardiotoxicity but a combination of Dox and agents with cardioprotective activities is an effective strategy to improve its therapeutic outcome. Natural products provide abundant resources to search for novel cardioprotective agents.

Identifiants

DOI: 10.1155/2022/9266178 PMID: 35693699 PMC: PMC9177334
pubmed: 35693699
doi: 10.1155/2022/9266178
pmc: PMC9177334
doi:

Substances chimiques

Doxorubicin 80168379AG
Heme Oxygenase (Decyclizing) EC 1.14.14.18
Heme Oxygenase-1 EC 1.14.14.18
Hmox1 protein, mouse EC 1.14.14.18
Hmox1 protein, rat EC 1.14.14.18
Membrane Proteins 0
mTOR protein, rat EC 2.7.1.1
NF-E2-Related Factor 2 0
Proto-Oncogene Proteins c-akt EC 2.7.11.1
TOR Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

9266178

Informations de copyright

Copyright © 2022 Jingjing Li et al.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Jingjing Li (J)

Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, Hong Kong Polytechnic University, Hong Kong SAR, China.
ORCID: 0000-0003-3636-0537

Yanfen Cheng (Y)

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Renkai Li (R)

Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Xiaoping Wu (X)

Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Chengwen Zheng (C)

Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Polly Ho-Ting Shiu (PH)

Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Jacqueline Cho-Ki Chan (JC)

Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Panthakarn Rangsinth (P)

Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Conghui Liu (C)

Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Susan Wai-Sum Leung (SW)

Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Simon Ming-Yuen Lee (SM)

State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.

Chen Zhang (C)

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Chaomei Fu (C)

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Jinming Zhang (J)

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Timothy Man-Yau Cheung (TM)

Tian Ran Healthcare Limited, Hong Kong, China.

George Pak-Heng Leung (GP)

Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
ORCID: 0000-0003-3529-9367

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Protective Effects of
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Protective Effects of
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Protective Effects of
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Protective Effects of
Recherchemedicale.com › Phénomènes physiques › Rayonnement › Cardiotoxicité › Protective Effects of
Recherchemedicale.com › Glucides › Hétérosides › Aminosides › Anthracyclines › Daunorubicine › Doxorubicine › Protective Effects of
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Heme oxygenase (decyclizing) › Protective Effects of
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Heme oxygenase (decyclizing) › Heme oxygenase-1 › Protective Effects of
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protective Effects of
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Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteur-2 apparenté à NF-E2 › Protective Effects of
Recherchemedicale.com › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Protective Effects of
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Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › Protective Effects of
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Transduction du signal › Protective Effects of
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Protective Effects of