Fc receptors and the diversity of antibody responses to HIV infection and vaccination.

AIDS Vaccines Antibodies, Neutralizing Antibody Formation HIV Antibodies / pharmacology HIV Infections HIV-1 Humans Receptors, Fc Vaccination

Journal

Genes and immunity
ISSN: 1476-5470
Titre abrégé: Genes Immun
Pays: England
ID NLM: 100953417

Informations de publication

Date de publication:
08 2022
Historique:
received: 16 02 2022
accepted: 24 05 2022
revised: 19 05 2022
pubmed: 11 6 2022
medline: 23 8 2022
entrez: 10 6 2022
Statut: ppublish

Résumé

The development of an effective vaccine against HIV is desperately needed. The successive failures of HIV vaccine efficacy trials in recent decades have shown the difficulty of inducing an appropriate protective immune response to fight HIV. Different correlates of antibody parameters associated with a decreased risk of HIV-1 acquisition have been identified. However, these parameters are difficult to reproduce and improve, possibly because they have an intricate and combined action. Here, we describe the numerous antibody (Ab) functions associated with HIV-1 protection and report the interrelated parameters regulating their complex functions. Indeed, besides neutralizing and Fc-mediated activity, additional factors such as Ab type, concentration and kinetics of induction, and Fc-receptor expression and binding capacity also influence the protective effect conferred by Abs. As these parameters were described to be associated with ethnicity, age and sex, these additional factors must be considered for the development of an effective immune response. Therefore, future vaccine designs need to consider these multifaceted Ab functions together with the demographic attributes of the patient populations.

Identifiants

DOI: 10.1038/s41435-022-00175-7 PMID: 35688931 PMC: PMC9388370
pubmed: 35688931
doi: 10.1038/s41435-022-00175-7
pii: 10.1038/s41435-022-00175-7
pmc: PMC9388370
doi:

Substances chimiques

AIDS Vaccines 0
Antibodies, Neutralizing 0
HIV Antibodies 0
Receptors, Fc 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

149-156

Informations de copyright

© 2022. The Author(s).

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Auteurs

Li-Yun Lin (LY)

Laboratoire d'ImmunoRhumatologie Moléculaire, Institut national de la santé et de la recherche médicale (INSERM) UMR_S 1109, Institut thématique interdisciplinaire (ITI) de Médecine de Précision de Strasbourg, Transplantex NG, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France.

Raphael Carapito (R)

Laboratoire d'ImmunoRhumatologie Moléculaire, Institut national de la santé et de la recherche médicale (INSERM) UMR_S 1109, Institut thématique interdisciplinaire (ITI) de Médecine de Précision de Strasbourg, Transplantex NG, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France.
Laboratoire d'Immunologie, Plateau Technique de Biologie, Pôle de Biologie, Nouvel Hôpital Civil, Strasbourg, France.
ORCID: 0000-0002-7036-442X

Bin Su (B)

Beijing Key Laboratory for HIV/AIDS Research, Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV Infection, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China.

Christiane Moog (C)

Laboratoire d'ImmunoRhumatologie Moléculaire, Institut national de la santé et de la recherche médicale (INSERM) UMR_S 1109, Institut thématique interdisciplinaire (ITI) de Médecine de Précision de Strasbourg, Transplantex NG, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France. c.moog@unistra.fr.
Vaccine Research Institute (VRI), Créteil, France. c.moog@unistra.fr.
ORCID: 0000-0002-0916-156X

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Classifications MeSH

Recherchemedicale.com › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Vaccins contre le SIDA › Fc receptors and the diversity of antibody...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Fc receptors and the diversity of antibody...
Recherchemedicale.com › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité active › Production d'anticorps › Fc receptors and the diversity of antibody...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Anticorps antideltarétrovirus › Anticorps anti-VIH › Fc receptors and the diversity of antibody...
Recherchemedicale.com › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Fc receptors and the diversity of antibody...
Recherchemedicale.com › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Fc receptors and the diversity of antibody...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Fc receptors and the diversity of antibody...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteur Fc › Fc receptors and the diversity of antibody...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Pratiques en santé publique › Prévention primaire › Immunisation › Vaccination › Fc receptors and the diversity of antibody...