Amiodarone-induced cutaneous leukocytoclastic vasculitis: a case report and a review of the literature.
Adverse effects
Amiodarone
Leukocytoclastic vasculitis
Skin ulcer
Journal
Clinical rheumatology
ISSN: 1434-9949
Titre abrégé: Clin Rheumatol
Pays: Germany
ID NLM: 8211469
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
11
02
2022
accepted:
30
05
2022
revised:
26
04
2022
pubmed:
3
6
2022
medline:
17
9
2022
entrez:
2
6
2022
Statut:
ppublish
Résumé
Amiodarone can be used in a variety of arrhythmias. Given its widespread use, the probability of clinicians encountering its cutaneous adverse effects is high. A few cases of amiodarone-induced cutaneous vasculitis were reported in the literature, probably because it is underdiagnosed in clinical practice. Indeed, amiodarone-related cutaneous reactions may present a wide range of manifestations and are sometimes difficult to diagnose. Herein, we report a case with a sizeable necrotic ulcer on the left lower leg shortly after amiodarone exposure. A rigorous diagnostic study was performed before concluding the diagnosis of amiodarone-induced cutaneous vasculitis, which showed the histopathological features of leukocytoclastic vasculitis. The lesion was almost completely healed by the third month of discontinuation of amiodarone. We did a literature search and found seven cases which were reported as leukocytoclastic or lymphocytic vasculitis. We reviewed previous cases and presented our case in comparison to prior cases.
Identifiants
pubmed: 35654917
doi: 10.1007/s10067-022-06231-x
pii: 10.1007/s10067-022-06231-x
doi:
Substances chimiques
Amiodarone
N3RQ532IUT
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2875-2881Informations de copyright
© 2022. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).
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