Thymol ameliorated neurotoxicity and cognitive deterioration in a thioacetamide-induced hepatic encephalopathy rat model; involvement of the BDNF/CREB signaling pathway.
Adenosine Triphosphate
/ metabolism
Animals
Brain-Derived Neurotrophic Factor
/ genetics
Cognition
Hepatic Encephalopathy
/ chemically induced
Liver
/ metabolism
Neurotoxicity Syndromes
/ drug therapy
Oxidative Stress
Rats
Rats, Wistar
Signal Transduction
Thioacetamide
/ toxicity
Thymol
/ pharmacology
Journal
Food & function
ISSN: 2042-650X
Titre abrégé: Food Funct
Pays: England
ID NLM: 101549033
Informations de publication
Date de publication:
06 Jun 2022
06 Jun 2022
Historique:
pubmed:
19
5
2022
medline:
9
6
2022
entrez:
18
5
2022
Statut:
epublish
Résumé
In the present study, we aimed to delineate the neuroprotective potential of thymol (THY) against neurotoxicity and cognitive deterioration induced by thioacetamide (TAA) in an experimental model of hepatic encephalopathy (HE). Rats received TAA (100 mg kg
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Thioacetamide
075T165X8M
Thymol
3J50XA376E
Adenosine Triphosphate
8L70Q75FXE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM