Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis.
anti-inflammatory
cytokine storm
inflammation
oxytocin
sepsis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
27
01
2022
accepted:
28
03
2022
entrez:
16
5
2022
pubmed:
17
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Sepsis is a potentially life-threatening systemic inflammatory syndrome characterized by dysregulated host immunological responses to infection. Uncontrolled immune cell activation and exponential elevation in circulating cytokines can lead to sepsis, septic shock, multiple organ dysfunction syndrome, and death. Sepsis is associated with high re-hospitalization and recovery may be incomplete, with long term sequelae including post-sepsis syndrome. Consequently, sepsis continues to be a leading cause of morbidity and mortality across the world. In our recent review of human chorionic gonadotropin (hCG), we noted that its major properties including promotion of fertility, parturition, and lactation were described over a century ago. By contrast, the anti-inflammatory properties of this hormone have been recognized only more recently. Vasopressin, a hormone best known for its anti-diuretic effect, also has anti-inflammatory actions. Surprisingly, vasopressin's close cousin, oxytocin, has broader and more potent anti-inflammatory effects than vasopressin and a larger number of pre-clinical studies supporting its potential role in limiting sepsis-associated organ damage. This review explores possible links between oxytocin and related octapeptide hormones and sepsis-related modulation of pro-inflammatory and anti-inflammatory activities.
Identifiants
pubmed: 35572539
doi: 10.3389/fimmu.2022.864007
pmc: PMC9102389
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Peptide Hormones
0
Vasopressins
11000-17-2
Oxytocin
50-56-6
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
864007Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM118182
Pays : United States
Informations de copyright
Copyright © 2022 Mehdi, Pusapati, Khenhrani, Farooqi, Sarwar, Alnasarat, Mathur, Metz, LeRoith, Tracey, Yang, Brownstein and Roth.
Déclaration de conflit d'intérêts
Author MJB was employed by Azevan Pharmaceuticals Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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