Non-Traditional Pathways for Platelet Pathophysiology in Diabetes: Implications for Future Therapeutic Targets.
diabetes
platelets
thrombo-inflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Apr 2022
29 Apr 2022
Historique:
received:
07
04
2022
revised:
26
04
2022
accepted:
27
04
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Cardiovascular complications remain the leading cause of morbidity and mortality in individuals with diabetes, driven by interlinked metabolic, inflammatory, and thrombotic changes. Hyperglycaemia, insulin resistance/deficiency, dyslipidaemia, and associated oxidative stress have been linked to abnormal platelet function leading to hyperactivity, and thus increasing vascular thrombotic risk. However, emerging evidence suggests platelets also contribute to low-grade inflammation and additionally possess the ability to interact with circulating immune cells, further driving vascular thrombo-inflammatory pathways. This narrative review highlights the role of platelets in inflammatory and immune processes beyond typical thrombotic effects and the impact these mechanisms have on cardiovascular disease in diabetes. We discuss pathways for platelet-induced inflammation and how platelet reprogramming in diabetes contributes to the high cardiovascular risk that characterises this population. Fully understanding the mechanistic pathways for platelet-induced vascular pathology will allow for the development of more effective management strategies that deal with the causes rather than the consequences of platelet function abnormalities in diabetes.
Identifiants
pubmed: 35563363
pii: ijms23094973
doi: 10.3390/ijms23094973
pmc: PMC9104718
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : British Heart Foundation
ID : FS/19/45/34443
Pays : United Kingdom
Références
Clin Appl Thromb Hemost. 2018 Dec;24(9_suppl):230S-239S
pubmed: 30309255
Eur J Clin Invest. 2004 Mar;34(3):205-9
pubmed: 15025679
EMBO Mol Med. 2016 Jul 01;8(7):779-95
pubmed: 27221050
Platelets. 2009 Dec;20(8):588-93
pubmed: 19835524
Diab Vasc Dis Res. 2006 May;3(1):52-6
pubmed: 16784182
Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1720-6
pubmed: 15242858
Redox Biol. 2019 Apr;22:101165
pubmed: 30877854
Biomed Res Int. 2015;2015:981841
pubmed: 26221610
Diabetes Care. 2002 Nov;25(11):1919-27
pubmed: 12401733
Am J Cardiol. 2015 Dec 1;116(11):1666-71
pubmed: 26455385
Transfusion. 2016 Mar;56 Suppl 1:S76-84
pubmed: 27001365
Blood. 2010 Sep 16;116(11):1951-7
pubmed: 20538795
Diabetes. 2016 Feb;65(2):349-51
pubmed: 26798121
J Am Coll Cardiol. 2006 Jan 17;47(2):391-7
pubmed: 16412866
Circ Res. 2010 Apr 30;106(8):1319-31
pubmed: 20431074
Compr Physiol. 2015 Jul 1;5(3):1265-80
pubmed: 26140718
J Cardiovasc Pharmacol. 2011 May;57(5):584-8
pubmed: 21326106
Front Immunol. 2019 Sep 13;10:2204
pubmed: 31572400
Semin Immunopathol. 2012 Jan;34(1):5-30
pubmed: 21818701
Nature. 2000 Apr 13;404(6779):787-90
pubmed: 10783895
Circulation. 2014 Apr 15;129(15):1598-609
pubmed: 24474649
Nat Rev Cardiol. 2015 Jan;12(1):30-47
pubmed: 25286881
JACC Basic Transl Sci. 2018 Mar 01;3(1):9-22
pubmed: 30062189
J Immunol. 1995 Nov 15;155(10):4917-25
pubmed: 7594496
J Clin Endocrinol Metab. 2010 Jun;95(6):2897-901
pubmed: 20382685
J Thromb Haemost. 2010 Apr;8(4):828-37
pubmed: 20088941
Bioessays. 2013 Nov;35(11):965-73
pubmed: 24115022
Diabetes. 2000 Nov;49(11):1939-45
pubmed: 11078463
Pulm Pharmacol Ther. 2011 Feb;24(1):100-9
pubmed: 20851205
Thromb Haemost. 2020 Feb;120(2):243-252
pubmed: 31942750
Circ Res. 1995 Jun;76(6):980-6
pubmed: 7758169
Atherosclerosis. 2003 May;168(1):73-80
pubmed: 12732389
JAMA. 2002 Oct 23-30;288(16):2008-14
pubmed: 12387653
Circ J. 2010 Apr;74(4):597-607
pubmed: 20197627
J Clin Invest. 2000 Aug;106(4):473-81
pubmed: 10953022
Thromb Haemost. 2011 May;105 Suppl 1:S43-54
pubmed: 21479339
Vasc Health Risk Manag. 2007;3(6):853-76
pubmed: 18200806
Diabetes Care. 2009 Apr;32(4):525-7
pubmed: 19336636
Metabolism. 2012 Nov;61(11):1528-37
pubmed: 22683098
N Engl J Med. 1988 Jul 28;319(4):208-12
pubmed: 3292913
Trends Endocrinol Metab. 2015 Oct;26(10):551-563
pubmed: 26412156
J Biol Chem. 2012 Dec 7;287(50):42373-8
pubmed: 23093403
Diabet Med. 2012 Jul;29(7):855-62
pubmed: 22537247
Herz. 2016 May;41(3):184-92
pubmed: 27026400
Circulation. 2005 Jan 25;111(3):363-8
pubmed: 15668353
Thromb Res. 2002 Apr 15;106(2):91-5
pubmed: 12182905
Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):417-22
pubmed: 16339499
J Immunol. 2019 Nov 1;203(9):2357-2367
pubmed: 31636134
Antioxidants (Basel). 2019 Jun 17;8(6):
pubmed: 31213029
PLoS One. 2019 Oct 23;14(10):e0224181
pubmed: 31644579
J Cardiovasc Dis Res. 2011 Jul;2(3):172-6
pubmed: 22022145
Arterioscler Thromb Vasc Biol. 2002 Jan;22(1):167-72
pubmed: 11788478
Curr Opin Pharmacol. 2006 Apr;6(2):136-41
pubmed: 16483848
Interv Med Appl Sci. 2012 Dec;4(4):181-5
pubmed: 24265874
Eur Heart J. 2007 Mar;28(5):540-5
pubmed: 17289742
Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):854-864
pubmed: 33297754
Thromb Haemost. 2014 Oct;112(4):678-91
pubmed: 25209670
J Exp Med. 2016 Mar 7;213(3):337-54
pubmed: 26926996
Int J Mol Sci. 2014 Dec 03;15(12):22342-64
pubmed: 25479079
Thromb Haemost. 2020 Mar;120(3):412-422
pubmed: 31975352
Exp Clin Endocrinol Diabetes. 2012 Apr;120(4):248-51
pubmed: 21922457
Pol Arch Med Wewn. 2014;124(11):617-27
pubmed: 25379971
Circ Res. 2001 Feb 2;88(2):E14-22
pubmed: 11157681
Int J Mol Sci. 2020 Aug 26;21(17):
pubmed: 32858930
J Clin Endocrinol Metab. 2012 Dec;97(12):E2282-7
pubmed: 22996148
Thromb Res. 2007;119(1):45-53
pubmed: 16480759
Cells. 2021 Feb 03;10(2):
pubmed: 33546399
Circ Res. 2015 Jul 3;117(2):157-65
pubmed: 25944670
Cardiovasc Diabetol. 2020 Jan 7;19(1):3
pubmed: 31910903
Diabetes. 2019 May;68(5):932-938
pubmed: 30765335
Genes (Basel). 2014 Sep 29;5(4):926-56
pubmed: 25268390
Diabet Med. 2009 Feb;26(2):142-8
pubmed: 19236616
Circ Res. 2010 Oct 29;107(9):1058-70
pubmed: 21030723
Cardiovasc Diabetol. 2019 Aug 30;18(1):113
pubmed: 31470851
Blood. 2011 Oct 6;118(14):e101-11
pubmed: 21596849
Expert Rev Cardiovasc Ther. 2016 Oct;14(10):1099-101
pubmed: 27460231
Am J Clin Nutr. 2018 Nov 1;108(5):1069-1091
pubmed: 30475962
Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):552-64
pubmed: 24458711
Diabetologia. 2005 Dec;48(12):2519-24
pubmed: 16247597
Front Cardiovasc Med. 2018 Jan 19;5:1
pubmed: 29404341
Circulation. 2007 Mar 27;115(12):1551-62
pubmed: 17353439
Lancet. 2009 Jun 27;373(9682):2215-21
pubmed: 19515410
Circulation. 2003 Sep 23;108(12):1527-32
pubmed: 14504252
Circulation. 2003 Jun 3;107(21):2664-9
pubmed: 12742991
Cardiovasc Res. 2004 Oct 1;64(1):172-8
pubmed: 15364625
Front Pharmacol. 2012 May 09;3:87
pubmed: 22582044
Semin Immunol. 2015 Sep;27(5):334-42
pubmed: 26776831
Diabetes. 2013 Jan;62(1):194-204
pubmed: 23086037
Int J Mol Sci. 2018 Sep 28;19(10):
pubmed: 30274207
Atherosclerosis. 2004 Oct;176(2):321-5
pubmed: 15380455
Circulation. 1997 Jul 1;96(1):69-75
pubmed: 9236419
Expert Rev Cardiovasc Ther. 2011 Jun;9(6):697-710
pubmed: 21714601
Diabetologia. 2008 Mar;51(3):385-90
pubmed: 18197397
Blood. 2012 Oct 11;120(15):e73-82
pubmed: 22869793
Cardiovasc Diabetol. 2017 Mar 9;16(1):34
pubmed: 28279217
Diabetes Metab Syndr Obes. 2019 Sep 20;12:1931-1942
pubmed: 31571967
Cell Mol Biol (Noisy-le-grand). 2016 Jan 22;62(1):73-83
pubmed: 26828992
Cardiovasc Diabetol. 2018 Nov 2;17(1):141
pubmed: 30388964
Platelets. 2006 Dec;17(8):577-85
pubmed: 17127486
N Engl J Med. 1990 Jun 21;322(25):1769-74
pubmed: 2345567
Eur Heart J. 2013 Aug;34(31):2436-43
pubmed: 23641007
J Thromb Haemost. 2018 Nov;16(11):2300-2314
pubmed: 30151891
Thromb Haemost. 2017 Feb 28;117(3):529-542
pubmed: 27975100
Thromb Res. 1982 Jun 1;26(5):359-70
pubmed: 6761893
Circulation. 2016 Nov 15;134(20):1579-1594
pubmed: 27729421
Front Immunol. 2021 Oct 25;12:748573
pubmed: 34759927
Crit Care Med. 2010 Feb;38(2 Suppl):S26-34
pubmed: 20083910
Thromb Res. 2014 Feb;133(2):235-43
pubmed: 24331207
Diabetologia. 2001 Feb;44(2):188-95
pubmed: 11270675
J Clin Invest. 2011 Nov;121(11):4462-76
pubmed: 22005299
Thromb Haemost. 2015 Aug 31;114(3):449-58
pubmed: 26293514
Diabetes Care. 2003 Jul;26(7):2181-8
pubmed: 12832332
Circ Res. 2016 Feb 19;118(4):620-36
pubmed: 26892962
Platelets. 2019;30(8):967-974
pubmed: 30388921
Sci Rep. 2016 Aug 26;6:32188
pubmed: 27561337
Diab Vasc Dis Res. 2007 Jun;4(2):84-8
pubmed: 17654441
Circulation. 2004 Jun 15;109(23 Suppl 1):III27-32
pubmed: 15198963
Circ Res. 2013 May 24;112(11):1506-19
pubmed: 23704217
Cardiovasc Diabetol. 2018 Aug 31;17(1):121
pubmed: 30170601
Diabetes Metab Res Rev. 2011 Mar;27(3):277-85
pubmed: 21309054