Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
03 05 2022
03 05 2022
Historique:
received:
18
06
2021
accepted:
04
04
2022
entrez:
3
5
2022
pubmed:
4
5
2022
medline:
6
5
2022
Statut:
epublish
Résumé
Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known as DU6, is one of the world's longest selection experiments for high body mass and was previously described as a model for metabolic healthy (benign) obesity. The present study further characterizes the geno- and phenotypes of this non-inbred mouse line and tests its suitability as an interventional obesity model. In contrast to previous findings, our data suggest that Titan mice are metabolically unhealthy obese and short-lived. Line-specific patterns of genetic invariability are in accordance with observed phenotypic traits. Titan mice also show modifications in the liver transcriptome, proteome, and epigenome linked to metabolic (dys)regulations. Importantly, dietary intervention partially reversed the metabolic phenotype in Titan mice and significantly extended their life expectancy. Therefore, the Titan mouse line is a valuable resource for translational and interventional obesity research.
Identifiants
pubmed: 35505192
doi: 10.1038/s42003-022-03339-3
pii: 10.1038/s42003-022-03339-3
pmc: PMC9065075
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
408Informations de copyright
© 2022. The Author(s).
Références
Hepatology. 2000 Jul;32(1):49-55
pubmed: 10869288
J Comp Physiol B. 2018 May;188(3):527-539
pubmed: 29214347
PLoS One. 2013 Nov 13;8(11):e79788
pubmed: 24236159
Appl Environ Microbiol. 2013 Sep;79(17):5112-20
pubmed: 23793624
J Anim Sci. 1997 Apr;75(4):934-40
pubmed: 9110204
Mutat Res. 1993 Dec;295(4-6):223-35
pubmed: 7507559
J Appl Genet. 2007;48(2):133-43
pubmed: 17495347
EMBO Rep. 2016 Mar;17(3):455-69
pubmed: 26781291
Nutr Metab (Lond). 2016 Oct 4;13:65
pubmed: 27708685
Nat Rev Gastroenterol Hepatol. 2019 Jan;16(1):35-56
pubmed: 30262901
Biochim Biophys Acta Gene Regul Mech. 2021 Feb;1864(2):194626
pubmed: 32827753
Diabetes. 2011 Oct;60(10):2441-9
pubmed: 21948998
Science. 2018 Nov 16;362(6416):770-775
pubmed: 30442801
Aging Cell. 2010 Feb;9(1):92-5
pubmed: 19878144
Am J Transl Res. 2016 Nov 15;8(11):4750-4763
pubmed: 27904677
Diabetes. 2015 Apr;64(4):1120-30
pubmed: 25315009
Mol Cell Endocrinol. 2015 Dec 15;418 Pt 1:66-73
pubmed: 26415590
Crit Pathw Cardiol. 2005 Dec;4(4):198-203
pubmed: 18340209
Nature. 2017 Jun 15;546(7658):381-386
pubmed: 28562591
Curr Obes Rep. 2015 Jun;4(2):224-9
pubmed: 26627217
Genes Dev. 1998 Mar 1;12(5):599-606
pubmed: 9499396
Curr Protoc Mouse Biol. 2015 Mar 02;5(1):65-84
pubmed: 25727201
Appl Environ Microbiol. 2009 Dec;75(23):7537-41
pubmed: 19801464
Dis Model Mech. 2010 Mar-Apr;3(3-4):156-66
pubmed: 20212084
Curr Neuropharmacol. 2009 Mar;7(1):50-9
pubmed: 19721817
Nucleic Acids Res. 2019 Jul 2;47(W1):W199-W205
pubmed: 31114916
Diabetologia. 2007 Sep;50(9):1867-1879
pubmed: 17618414
Genes (Basel). 2019 May 27;10(5):
pubmed: 31137904
JAMA. 2003 Jan 8;289(2):187-93
pubmed: 12517229
J Immunol Res. 2014;2014:149185
pubmed: 24901008
Cell Metab. 2020 Jan 7;31(1):92-104.e5
pubmed: 31813824
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
BMJ Open. 2019 Jul 31;9(7):e028086
pubmed: 31371290
Genome Biol. 2014;15(12):550
pubmed: 25516281
Trends Biochem Sci. 2016 Aug;41(8):700-711
pubmed: 27283514
Nat Methods. 2005 Jun;2(6):403-4
pubmed: 15908916
Cell Rep. 2014 May 8;7(3):821-33
pubmed: 24746817
PLoS Biol. 2020 Feb 25;18(2):e3000629
pubmed: 32097406
Cell. 2015 Mar 26;161(1):106-118
pubmed: 25815989
Mo Med. 2013 May-Jun;110(3):220-2
pubmed: 23829107
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Age (Dordr). 2016 Feb;38(1):23
pubmed: 26846415
Nat Commun. 2015 Sep 18;6:8332
pubmed: 26383889
Nat Rev Cancer. 2009 Nov;9(11):798-809
pubmed: 19851315
Microbes Environ. 2014;29(4):427-30
pubmed: 25283478
Bioessays. 2017 Dec;39(12):
pubmed: 29052843
J Clin Invest. 2020 Sep 1;130(9):4985-4998
pubmed: 32516139
Mol Cell Neurosci. 2007 Aug;35(4):559-72
pubmed: 17618127
Appl Environ Microbiol. 2014 Aug;80(16):5116-23
pubmed: 24928874
Nutr Diabetes. 2011 Jan 31;1:e1
pubmed: 23154293
Cells. 2022 Jan 29;11(3):
pubmed: 35159278
Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25250-25259
pubmed: 31757851
J Proteome Res. 2011 Apr 1;10(4):1794-805
pubmed: 21254760
FASEB J. 2020 Feb;34(2):2425-2435
pubmed: 31907998
Nat Commun. 2021 Mar 19;12(1):1745
pubmed: 33741971
Metabolism. 2019 Mar;92:51-60
pubmed: 30458177
Antioxidants (Basel). 2021 Apr 08;10(4):
pubmed: 33917812
Clin Pharmacol Ther. 2009 Apr;85(4):434-8
pubmed: 19212314
Curr Biol. 2013 May 20;23(10):R451-3
pubmed: 23701689
Int J Clin Exp Med. 2015 Aug 15;8(8):13491-9
pubmed: 26550286
World J Diabetes. 2014 Aug 15;5(4):415-9
pubmed: 25126389
Cell Syst. 2015 Dec 23;1(6):417-425
pubmed: 26771021
Nat Rev Endocrinol. 2019 Apr;15(4):207-225
pubmed: 30733616
Theor Appl Genet. 1985 Apr;70(1):72-9
pubmed: 24254117
Bioinformatics. 2011 Aug 1;27(15):2156-8
pubmed: 21653522
Cell. 2015 Dec 3;163(6):1539-54
pubmed: 26638078
BMC Biol. 2022 Feb 21;20(1):52
pubmed: 35189878
Nat Rev Endocrinol. 2018 Mar;14(3):140-162
pubmed: 29348476
Mol Cell. 2015 Feb 5;57(3):559-71
pubmed: 25578876
Nat Protoc. 2016 Dec;11(12):2301-2319
pubmed: 27809316
Curr Protoc Bioinformatics. 2015 Sep 03;51:11.14.1-11.14.19
pubmed: 26334920
Int J Obes Relat Metab Disord. 1999 Jun;23(6):586-94
pubmed: 10411231
Semin Immunopathol. 2020 Oct;42(5):573-587
pubmed: 32785750
Genet Res. 1998 Oct;72(2):93-109
pubmed: 9883096
Eur J Med Res. 2010 Nov 4;15 Suppl 2:120-2
pubmed: 21147638
Trends Genet. 2002 Jul;18(7):367-76
pubmed: 12127777
Mol Cell Proteomics. 2014 Sep;13(9):2513-26
pubmed: 24942700
Pharmacogenomics. 2004 Apr;5(3):305-18
pubmed: 15102545
Diabetes. 2008 May;57(5):1246-53
pubmed: 18252893
Cell. 2015 Jan 15;160(1-2):132-44
pubmed: 25542313
Cells. 2020 Jun 22;9(6):
pubmed: 32580353
Diabetes Care. 2013 Nov;36(11):3732-8
pubmed: 24026559
Trends Genet. 2020 Apr;36(4):259-272
pubmed: 32037011
Endocrinology. 2012 Sep;153(9):4238-45
pubmed: 22778214
Cell Metab. 2006 Jun;3(6):429-38
pubmed: 16753578
Aging Cell. 2009 Apr;8(2):113-27
pubmed: 19239417
Nutrients. 2020 Oct 22;12(11):
pubmed: 33105762
Biochem Pharmacol. 2020 Jul;177:113973
pubmed: 32283053
Evolution. 1984 Nov;38(6):1358-1370
pubmed: 28563791
Biochem J. 2003 Aug 15;374(Pt 1):1-20
pubmed: 12773095
Curr Protoc Mouse Biol. 2013 Jun 01;3(2):69-100
pubmed: 26069059
Annu Rev Nutr. 2012 Aug 21;32:261-86
pubmed: 22404118
PLoS One. 2014 Jan 21;9(1):e86637
pubmed: 24466182
Methods Mol Biol. 2016;1418:335-51
pubmed: 27008022
Methods. 2011 Feb;53(2):120-35
pubmed: 20708688
J Investig Med. 2012 Dec;60(8):1141-6
pubmed: 23072902
Mediators Inflamm. 2010;2010:
pubmed: 20706689
Obesity (Silver Spring). 2008 Mar;16(3):522-30
pubmed: 18239594
Reproduction. 2021 May 14;161(6):721-730
pubmed: 33878028
Nat Commun. 2021 Oct 21;12(1):6137
pubmed: 34675233
J Clin Invest. 2003 Dec;112(12):1796-808
pubmed: 14679176
Transl Res. 2014 Oct;164(4):323-35
pubmed: 24880146
CMAJ. 2005 Feb 1;172(3):367-79
pubmed: 15684121