Gene Polymorphisms Increasing the Risk of Intracranial Aneurysms: Interleukin-6 -174G>C and -572G>C (Part II).
Journal
Acta bio-medica : Atenei Parmensis
ISSN: 2531-6745
Titre abrégé: Acta Biomed
Pays: Italy
ID NLM: 101295064
Informations de publication
Date de publication:
21 03 2022
21 03 2022
Historique:
received:
09
12
2021
accepted:
27
01
2022
entrez:
20
4
2022
pubmed:
21
4
2022
medline:
22
4
2022
Statut:
epublish
Résumé
Introduction The interleukin-6 (IL-6), a proinflammatory cytokine, supports the adaptive immune response and regulates inflammatory processes. The -174 G>C and -572 G>C promoter polymorphisms of the IL-6 gene take part in the pathogenesis of intracranial aneurysms (IAs) and influence the clinical presentation of subarachnoid hemorrhage. This meta-analysis purposes to evaluate whether and which IL-6 allelic variations are related to a risk of IAs formation. Methods A PRISMA-based literature search was performed on the PubMed/Medline and Web of Science databases. The keywords used were "interleukin-6," "IL-6," "polymorphism," "interleukin-6 genotype," combined with "intracranial aneurysms" and "subarachnoid hemorrhage." Only human case-control studies, with a study (IAs) and a control group, written in English, and published in the last 15 years were selected. A meta-analysis was performed, estimating odds ratios and 95% confidence intervals in fixed- or random-effects models, as applicable. Statistical analysis was conducted with RevMan 5.0 software. Results 9 studies were eligible. No associations were found between -174 G>C polymorphisms and IAs susceptibility. Notable results were reported by the analysis of -572G>C polymorphisms. -572GG/GC/CC genotypes were strongly related to IAs occurrence with a statistical significance of p=0.03, p=0.0009, and p=0.00001, respectively. Conclusion A higher incidence of -572G>C promoter polymorphisms were demonstrated in the IAs group, highlighting the pivotal role of inflammatory genes in the natural history of brain aneurysms. Additional studies are required considering the racial heterogenicity and the need to widen the population sample.
Identifiants
pubmed: 35441611
doi: 10.23750/abm.v92iS4.12669
pmc: PMC9179066
doi:
Substances chimiques
IL6 protein, human
0
Interleukin-6
0
Types de publication
Journal Article
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2021420Références
Int J Neurosci. 2013 Sep;123(9):626-35
pubmed: 23510010
J Neurosurg Spine. 2008 Jan;8(1):92-9
pubmed: 18173354
J Neurointerv Surg. 2010 Jun;2(2):120-30
pubmed: 21990591
Crit Care Med. 2005 Dec;33(12 Suppl):S463-5
pubmed: 16340422
Stem Cells. 2016 Dec;34(12):2943-2955
pubmed: 27350036
Expert Rev Neurother. 2015 Apr;15(4):367-80
pubmed: 25719927
Nat Rev Neurol. 2014 Jan;10(1):44-58
pubmed: 24323051
Medicina (Kaunas). 2021 Jul 22;57(8):
pubmed: 34440948
Clin Sci (Lond). 2008 Jun;114(11):687-97
pubmed: 18078385
Shock. 2003 Sep;20(3):218-23
pubmed: 12923492
NPJ Regen Med. 2019 May 13;4:10
pubmed: 31098299
J Neurosurg. 2019 Dec 06;132(6):2014-2016
pubmed: 31812150
Br J Neurosurg. 2001 Dec;15(6):456-63
pubmed: 11813996
J Neurosurg. 2017 Aug;127(2):291-301
pubmed: 27715439
Acta Biomed. 2020 Jun 30;91(7-S):5-17
pubmed: 32608372
J Neurol Neurosurg Psychiatry. 2006 Aug;77(8):915-7
pubmed: 16648144
PLoS One. 2021 Feb 18;16(2):e0247153
pubmed: 33600491
Neurochem Res. 2015 Jul;40(7):1537-45
pubmed: 26093650
Clin Chem Lab Med. 2000 Nov;38(11):1161-4
pubmed: 11156350
J Cereb Blood Flow Metab. 2012 Sep;32(9):1659-76
pubmed: 22781330
Cytokine. 2017 Sep;97:96-103
pubmed: 28609751
Biomed Pharmacother. 2021 Jan;133:111048
pubmed: 33378955
Neurosurgery. 2010 Jun;66(6):1058-62; discussion 1062-3
pubmed: 20495422
Cerebrovasc Dis. 2018;45(3-4):180-186
pubmed: 29614486
Int J Mol Sci. 2018 Jul 13;19(7):
pubmed: 30011792
Ital J Pediatr. 2018 Nov 20;44(1):140
pubmed: 30458831
Neurosurg Focus. 1997 Sep 15;3(3):e2
pubmed: 15104414
Cell. 2010 Mar 19;140(6):805-20
pubmed: 20303872
Genet Test Mol Biomarkers. 2010 Dec;14(6):759-63
pubmed: 20939703
Neurosci Lett. 2000 Apr 21;284(1-2):73-6
pubmed: 10771165
Lancet Neurol. 2011 Jul;10(7):626-36
pubmed: 21641282
Inflammation. 2009 Aug;32(4):233-41
pubmed: 19462226
J Neurol Sci. 2011 Jul 15;306(1-2):94-7
pubmed: 21497830
Eur J Vasc Endovasc Surg. 2008 Jan;35(1):31-6
pubmed: 17996468
eNeurologicalSci. 2018 Nov 27;14:31-33
pubmed: 30555950
Am Soc Clin Oncol Educ Book. 2016;35:e132-9
pubmed: 27249715
Nat Clin Pract Neurol. 2007 May;3(5):256-63
pubmed: 17479073
Stroke. 2004 Oct;35(10):2287-93
pubmed: 15322297
J Neurosurg. 2012 Mar;116(3):638-42
pubmed: 22117185
World Neurosurg. 2019 Mar;123:159-160
pubmed: 30580066
Heliyon. 2019 Nov 26;5(11):e02818
pubmed: 31844735
World Neurosurg. 2018 May;113:e122-e128
pubmed: 29408591
Stroke. 1998 Jan;29(1):251-6
pubmed: 9445359
Neurology. 1998 May;50(5):1413-8
pubmed: 9595997
Lancet. 2003 Jul 12;362(9378):103-10
pubmed: 12867109
Arterioscler Thromb Vasc Biol. 2001 Sep;21(9):1458-63
pubmed: 11557672
J Neuroinflammation. 2015 Jul 22;12:135
pubmed: 26198819
JAMA Neurol. 2019 May 1;76(5):588-597
pubmed: 30659573
Eur J Paediatr Neurol. 2019 Jan;23(1):43-52
pubmed: 30502045
Stroke. 2011 Nov;42(11):3156-62
pubmed: 21980208
J Neuroinflammation. 2019 Jan 15;16(1):8
pubmed: 30646897
Front Genet. 2021 Jun 08;12:679363
pubmed: 34168680
Neurosurg Focus. 2019 Jul 1;47(1):E2
pubmed: 31261124
Trends Neurosci. 2000 Dec;23(12):618-25
pubmed: 11137152
Data Brief. 2020 Nov 20;33:106537
pubmed: 33294525
Curr Neuropharmacol. 2018;16(9):1385-1395
pubmed: 29651951
Lancet. 2007 Jan 27;369(9558):306-18
pubmed: 17258671
Acta Biomed. 2020 Jun 30;91(7-S):79-100
pubmed: 32608377
J Neuroinflammation. 2012 Sep 21;9:222
pubmed: 22999528
World Neurosurg. 2020 Feb;134:660
pubmed: 32059273
Neuro Endocrinol Lett. 2004 Feb-Apr;25(1-2):141-7
pubmed: 15159698
Yonsei Med J. 2020 May;61(5):391-399
pubmed: 32390362
J Korean Med Sci. 2001 Dec;16(6):774-80
pubmed: 11748361
Acta Biomed. 2020 Jun 30;91(7-S):51-60
pubmed: 32608375
Lab Invest. 1989 Dec;61(6):588-602
pubmed: 2481148
Thromb Res. 2003 Jun 1;110(4):181-6
pubmed: 14512079
Hum Immunol. 2013 Dec;74(12):1679-83
pubmed: 23993981
Int J Mol Sci. 2021 May 21;22(11):
pubmed: 34064048
Front Immunol. 2021 Mar 08;12:630381
pubmed: 33763073
Semin Neonatol. 2000 Feb;5(1):3-16
pubmed: 10802746
Acta Neurochir (Wien). 1998;140(9):943-51
pubmed: 9842432
Seizure. 2020 Oct;81:76-83
pubmed: 32769034
Neurosurg Focus. 2019 Jul 1;47(1):E10
pubmed: 31261114
Annu Rev Fluid Mech. 2009 Jan 1;41:91-107
pubmed: 19784385
Curr Atheroscler Rep. 2017 Oct 23;19(12):50
pubmed: 29063300
J Neurosci Res. 2004 Oct 15;78(2):151-6
pubmed: 15378607
Neurobiol Aging. 2001 Nov-Dec;22(6):903-8
pubmed: 11754997
Medicina (Kaunas). 2020 Apr 24;56(4):
pubmed: 32344710
Crit Care Med. 1995 Jun;23(6):1007-17
pubmed: 7774210
Int J Stroke. 2015 Oct;10 Suppl A100:38-45
pubmed: 26120925
Biochem Biophys Res Commun. 2010 Apr 30;395(2):264-9
pubmed: 20371223
Genet Test Mol Biomarkers. 2012 Jul;16(7):822-6
pubmed: 22686131
Eur J Clin Invest. 1999 Feb;29(2):93-9
pubmed: 10092995
AJNR Am J Neuroradiol. 2019 Mar;40(3):510-516
pubmed: 30733253
Stroke. 2011 Mar;42(3):783-91
pubmed: 21293018
J Neuroinflammation. 2021 Jan 18;18(1):25
pubmed: 33461586
Stroke. 2006 Jul;37(7):1868-74
pubmed: 16741174
Int J Environ Res Public Health. 2019 Apr 10;16(7):
pubmed: 30974872
J Neurol. 2020 Dec;267(12):3555-3564
pubmed: 32623596
Neurosci Lett. 2008 Jul 25;440(1):1-3
pubmed: 18487018
Int J Mol Sci. 2021 Jul 08;22(14):
pubmed: 34298971
Genomics. 1988 Jul;3(1):8-16
pubmed: 2906047
Atherosclerosis. 2004 May;174(1):157-63
pubmed: 15135265
N Engl J Med. 2006 Jan 26;354(4):387-96
pubmed: 16436770
Acta Biomed. 2020 Jun 30;91(7-S):18-31
pubmed: 32608373
Acta Neuropathol. 2012 Jun;123(6):773-86
pubmed: 22249619
Gene. 2012 Jul 15;503(1):25-30
pubmed: 22575724
N Engl J Med. 1998 Dec 10;339(24):1725-33
pubmed: 9867550
Mult Scler Relat Disord. 2019 Dec 24;39:101917
pubmed: 31896061
Neuro Oncol. 2014 Nov;16(11):1441-58
pubmed: 25190673
J Neuroinflammation. 2008 Feb 26;5:7
pubmed: 18302763
Biomed Res Int. 2021 Jan 16;2021:8865601
pubmed: 33511216
Prog Cardiovasc Dis. 2007 Mar-Apr;49(5):307-29
pubmed: 17329179
World Neurosurg. 2014 Dec;82(6):1127-30
pubmed: 23548847
Transl Stroke Res. 2014 Jun;5(3):347-56
pubmed: 24683005
J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):279-80
pubmed: 16421145
Int J Mol Sci. 2019 Jun 20;20(12):
pubmed: 31226744
Brain Sci. 2021 Jul 23;11(8):
pubmed: 34439595
Acta Neurol Scand. 2012 Feb;125(2):111-5
pubmed: 21410438
PLoS One. 2012;7(4):e34839
pubmed: 22509361
Arch Dis Child. 2019 Aug;104(8):768-774
pubmed: 30948362
Lancet Neurol. 2011 Jul;10(7):595-7
pubmed: 21641283
J Cereb Blood Flow Metab. 2017 Mar;37(3):967-979
pubmed: 27174997
Int Immunopharmacol. 2018 Dec;65:342-347
pubmed: 30366277
Surg Neurol Int. 2018 Jan 25;9:19
pubmed: 29497572
Am J Obstet Gynecol. 1997 Jul;177(1):19-26
pubmed: 9240577
Stroke. 2009 Mar;40(3 Suppl):S86-7
pubmed: 19064787
World Neurosurg. 2020 Dec;144:e119-e137
pubmed: 32949801
Mult Scler Relat Disord. 2020 Jun;41:102011
pubmed: 32163756
Ital J Pediatr. 2018 Apr 4;44(1):44
pubmed: 29618369
J Neuroinflammation. 2014 Apr 16;11:77
pubmed: 24739142
Ann Neurol. 2013 Sep;74(3):458-71
pubmed: 23674483
Eur J Radiol. 2013 Oct;82(10):1598-605
pubmed: 23399038
Int J Mol Sci. 2020 Apr 14;21(8):
pubmed: 32295146
Neurosurgery. 1996 Sep;39(3):537-45; discussion 545-7
pubmed: 8875484
J Neurol Neurosurg Psychiatry. 2008 Apr;79(4):471-3
pubmed: 18344399
Brain Sci. 2021 Mar 18;11(3):
pubmed: 33803885
Eur J Pediatr. 1993 Apr;152(4):309-12
pubmed: 8482278
Circulation. 2014 Jan 21;129(3):373-82
pubmed: 24446407
Stroke. 1999 Jul;30(7):1396-401
pubmed: 10390313
World Neurosurg. 2017 Sep;105:895-905
pubmed: 28559081
Arthritis Rheum. 2004 Jun;50(6):1976-83
pubmed: 15188375
J Int Med Res. 2017 Dec;45(6):2128-2138
pubmed: 28661267
J Clin Invest. 1998 Oct 1;102(7):1369-76
pubmed: 9769329
BMC Infect Dis. 2016 Jun 10;16:277
pubmed: 27287521
Brain. 2017 Jul 1;140(7):1914-1931
pubmed: 28535201