Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates.

Anti-Bacterial Agents / pharmacology Ciprofloxacin / pharmacology Humans Meropenem / pharmacology Microbial Sensitivity Tests Pseudomonas Infections / drug therapy Pseudomonas aeruginosa Shock, Septic / drug therapy
Hollow-Fiber Infection Model Pseudomonas aeruginosa combination therapy

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
17 05 2022
Historique:
pubmed: 8 4 2022
medline: 20 5 2022
entrez: 7 4 2022
Statut: ppublish

Résumé

Meropenem-ciprofloxacin combination therapy was compared to the respective monotherapy in a Hollow-Fiber Infection Model against two Pseudomonas aeruginosa isolates. Following initial kill of ∼ 5-logs by each monotherapy, rapid regrowth occurred within 24 h, reaching 10

Identifiants

DOI: 10.1128/aac.02140-21 PMID: 35389238 PMC: PMC9112939
pubmed: 35389238
doi: 10.1128/aac.02140-21
pmc: PMC9112939
doi:

Substances chimiques

Anti-Bacterial Agents 0
Ciprofloxacin 5E8K9I0O4U
Meropenem FV9J3JU8B1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0214021

Références

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Auteurs

Natalija Karabasevic (N)

Medical Programme, Faculty of Medicine, Lund University, Lund, Sweden.
ORCID: 0000-0003-0565-644X

Jason A Roberts (JA)

Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.
The University of Queenslandgrid.1003.2 Centre for Clinical Research, Brisbane, Queensland, Australia.
Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France.
ORCID: 0000-0001-6218-435X

Luke Stronach (L)

Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.

Saiyuri Naicker (S)

Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.
The University of Queenslandgrid.1003.2 Centre for Clinical Research, Brisbane, Queensland, Australia.

Steven C Wallis (SC)

The University of Queenslandgrid.1003.2 Centre for Clinical Research, Brisbane, Queensland, Australia.

Fredrik Sjövall (F)

Department of Intensive Care and Perioperative Medicine, Skane University Hospital, Malmö, Sweden.
Mitochondrial Medicine, Lund University, Lund, Sweden.

Fekade Sime (F)

Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.
The University of Queenslandgrid.1003.2 Centre for Clinical Research, Brisbane, Queensland, Australia.
ORCID: 0000-0003-4061-2063

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Classifications MeSH

Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Use of the Hollow-Fiber Infection Model to...
Recherchemedicale.com › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinolinone › Fluoroquinolones › Ciprofloxacine › Use of the Hollow-Fiber Infection Model to...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Use of the Hollow-Fiber Infection Model to...
Recherchemedicale.com › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Carbapénèmes › Thiénamycine › Méropénème › Use of the Hollow-Fiber Infection Model to...
Recherchemedicale.com › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Use of the Hollow-Fiber Infection Model to...
Recherchemedicale.com › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Pseudomonas › Use of the Hollow-Fiber Infection Model to...
Recherchemedicale.com › Bactéries › Proteobacteria › Gammaproteobacteria › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa › Use of the Hollow-Fiber Infection Model to...
Recherchemedicale.com › États, signes et symptômes pathologiques › Processus pathologiques › Choc › Syndrome de réponse inflammatoire généralisée › Choc septique › Use of the Hollow-Fiber Infection Model to...