Temporal lobe epilepsy lateralisation and surgical outcome prediction using diffusion imaging.
epilepsy, surgery
image analysis
neurosurgery
Journal
Journal of neurology, neurosurgery, and psychiatry
ISSN: 1468-330X
Titre abrégé: J Neurol Neurosurg Psychiatry
Pays: England
ID NLM: 2985191R
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
06
10
2021
accepted:
02
03
2022
pubmed:
30
3
2022
medline:
1
6
2022
entrez:
29
3
2022
Statut:
ppublish
Résumé
We sought to augment the presurgical workup of medically refractory temporal lobe epilepsy by creating a supervised machine learning technique that uses diffusion-weighted imaging to classify patient-specific seizure onset laterality and surgical outcome. 151 subjects were included in this analysis: 62 patients (aged 18-68 years, 36 women) and 89 healthy controls (aged 18-71 years, 47 women). We created a supervised machine learning technique that uses diffusion-weighted metrics to classify subject groups. Specifically, we sought to classify patients versus healthy controls, unilateral versus bilateral temporal lobe epilepsy, left versus right temporal lobe epilepsy and seizure-free versus not seizure-free surgical outcome. We then reduced the dimensionality of derived features with community detection for ease of interpretation. We classified the subject groups in withheld testing data sets with a cross-fold average testing areas under the receiver operating characteristic curve of 0.745 for patients versus healthy controls, 1.000 for unilateral versus bilateral seizure onset, 0.662 for left versus right seizure onset, 0.800 for left-sided seizure-free vsersu not seizure-free surgical outcome and 0.775 for right-sided seizure-free versus not seizure-free surgical outcome. This technique classifies important clinical decisions in the presurgical workup of temporal lobe epilepsy by generating discerning white-matter features. We believe that this work augments existing network connectivity findings in the field by further elucidating important white-matter pathology in temporal lobe epilepsy. We hope that this work contributes to recent efforts aimed at using diffusion imaging as an augmentation to the presurgical workup of this devastating neurological disorder.
Identifiants
pubmed: 35347079
pii: jnnp-2021-328185
doi: 10.1136/jnnp-2021-328185
pmc: PMC9149039
mid: NIHMS1786677
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
599-608Subventions
Organisme : NINDS NIH HHS
ID : R01 NS075270
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS112252
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110130
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007347
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103537
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS108445
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS120401
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Neurology. 2017 Jun 13;88(24):2285-2293
pubmed: 28515267
Neuroimage. 2014 Oct 15;100:135-44
pubmed: 24814212
Eur Radiol. 2019 Dec;29(12):6750-6761
pubmed: 31286187
Epilepsia. 2017 May;58(5):792-800
pubmed: 28378422
Ann Neurol. 2020 Nov;88(5):970-983
pubmed: 32827235
Rev Neurol (Paris). 2016 Jan;172(1):27-36
pubmed: 26754036
J Neurosurg. 2018 Jul;129(1):165-173
pubmed: 29027858
Clin Neurophysiol. 2020 Jan;131(1):114-126
pubmed: 31760210
Curr Opin Neurol. 2018 Apr;31(2):198-210
pubmed: 29493559
Neuroimage. 2019 Nov 15;202:116137
pubmed: 31473352
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
Neuroimage. 2015 Oct 1;119:338-51
pubmed: 26163802
Neuroimage Clin. 2021;31:102765
pubmed: 34339947
Lancet Neurol. 2008 Jun;7(6):525-37
pubmed: 18485316
Epilepsia. 2017 Dec;58(12):2133-2142
pubmed: 28994113
Epilepsia. 2019 Jun;60(6):1171-1183
pubmed: 31112302
Neurology. 1993 Aug;43(8):1612-7
pubmed: 8102482
Curr Med Imaging Rev. 2019;15(1):39-51
pubmed: 31964326
Neuroimage. 2004 Nov;23(3):1176-85
pubmed: 15528117
Epilepsy Res. 2021 Mar;171:106571
pubmed: 33582534
Epilepsy Curr. 2012 Sep;12(5):203-4
pubmed: 23118610
Lancet Neurol. 2015 Mar;14(3):283-90
pubmed: 25638640
Magn Reson Med. 2021 Jul;86(1):456-470
pubmed: 33533094
Nat Neurosci. 2018 Apr;21(4):474-483
pubmed: 29507407
Curr Opin Neurol. 2014 Apr;27(2):213-8
pubmed: 24553465
Neuroimage. 2004;23 Suppl 1:S208-19
pubmed: 15501092
J Epilepsy Res. 2020 Jun 30;10(1):8-17
pubmed: 32983950
Neuroimage Clin. 2015 Oct 30;11:694-706
pubmed: 27330966
Neuroimage Clin. 2015 Feb 20;8:322-8
pubmed: 26106557
PLoS One. 2020 Jul 31;15(7):e0236418
pubmed: 32735601
JAMA. 2012 Mar 7;307(9):922-30
pubmed: 22396514
Epilepsia. 2013 Dec;54(12):2048-59
pubmed: 24117098
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:5525-5528
pubmed: 28325026
Neurology. 2016 Dec 6;87(23):2483-2489
pubmed: 27920283
Epilepsia. 2018 Sep;59(9):1643-1654
pubmed: 30098002