Multi-organ/disseminated echinococcosis in children: Case series and review of the literature.
children
disseminated
echinococcosis
multiorgan
Journal
Journal of paediatrics and child health
ISSN: 1440-1754
Titre abrégé: J Paediatr Child Health
Pays: Australia
ID NLM: 9005421
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
24
01
2022
received:
01
12
2021
accepted:
23
02
2022
pubmed:
10
3
2022
medline:
6
7
2022
entrez:
9
3
2022
Statut:
ppublish
Résumé
Echinococcosis with multi-organ/disseminated involvement is rare in childhood. We aimed to evaluate the clinical and laboratory characteristics and prognosis in paediatric patients with echinococcosis having multiorgan/disseminated involvement. We evaluated retrospectively children with echinococcosis with involvement of three or more organs. Thirteen patients were included in the study. The median age was 120 (range 71-189) months. Three (23%) were diagnosed incidentally. Abdominal pain was seen in 5 (38.4%) patients, vomiting in 4 (30.7%), headache in 3 (23%), cough in 2 (15.3%), groin pain in 1 (7.6%), 1 (7.6%) had jaundice and 1 (7.6%) had fever. The median duration of complaints was 48 (0-140) days. The most common tripartite organ was 38.4% (5/13) liver, lung and spleen. Isolated abdominal dissemination was detected in two patients. Two patients had multi-organ involvement and multiple cysts with dissemination. Cyst rupture was observed in three of the patients; recurrent urinary tract infection, hydroureteronephrosis, secondary peritonitis with intra-abdominal abscess, and biliary tract fistula were each observed in one patient. Relapse developed in 3 (23%) patients. Echinococcosis is a very slow growing and complex parasitic disease that affects many organs and tissues. In our study, eosinophilia, recurrence, and complications were seen at a higher rate in paediatric patients with multiorgan involvement, who required repetitive surgeries and long-term medical treatment. However, there are scanty data on risk factors, optimum treatment and prognosis.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1193-1200Informations de copyright
© 2022 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).
Références
WHO. Echinococcosis. Available from: https://www.who.int/home/newsroom/factsheets/detail/namingthe-Echinococcosis [accessed 9 September 2021]
Serpa JA, Cabada MM, Mason EO, White AC. Parasitic diseases. Sestodes. In: Cherry JD, Kaplan SL, Steinbach WJ, Hotez PJ, eds. Feiginand Cherry's Textbook of Pediatric Infectious Diseases, 8th edn. Philadelphia, PA: Elsevier; 2018; 2252-5.
Moro PL. Clinical manifestations and diagnosis of echinococcosis. Available from: http://www.uptodate.com/contents/Clinical-manifestations-and-diagnosis-of-echinococcosis [accessed October 2021].
Harrris K, Morris D, Tudor R, Toghill P, Hardcastle J. Clinical and radiographic features of simple and hydatid cysts of the liver. Br. J. Surg. 1986; 73: 835-8.
Del Carpio M, Mercapide CH, Salvitti JC et al. Early diagnosis, treatment and follow-up of cystic echinococcosis in remote rural areas in Patagonia: Impact of ultrasound training of non-specialists. PLoS Negl. Trop. Dis. 2012; 6: e1444.
Tartar T, Bakal U, Sarac M, Kazez A. Laboratory results and clinical findings of children with hydatid cyst disease. Niger. J. Clin. Pract. 2020; 23: 1008-12.
Öztorun Cİ, Demir S, D Güney D et al. An unsolved problem in developing countries: Hydatid cysts in children. Pediatr. Surg. Int. 2021; 37: 1235-41.
Şişmanlar Eyüboğlu T, Ramaslı Gürsoy T, Tana Aslan A, Pekcan S, Budakoğlu Iİ. Ten-year follow-up of children with hydatid cysts. Turk. Pediatr. Ars. 2019; 54: 173-8.
Mohammadi M, Mamishi S, Pourakbari B, Faraz Z, Khodabandeh M, Mahmoudi S. Cystic echinococcosis in children: High frequency of multiple organs involved in the north of Iran. Infect. Disord. Drug Targets 2021; 21: 125-9.
Kaman A, Tanır G, Çakmakçı E et al. Characteristics, diagnosis, and treatment modality of pediatric patients with cystic echinococcosis: A single centre experience. Turk. J. Pediatr. 2019; 61: 704-13.
Öztürk HH, Öztürk H, Otçu S, Önen A, Duran H. Hydatid cysts in children: Analysis of 49 cases. Turk. J. Surg. 2006; 22: 17-20.
Koca T, Dereci S, Gençer A et al. Cystic echinococcosis in childhood: Five-years of experience from a single-center. Turkiye Parazitol. Derg. 2016; 40: 26-31.
Iyigun O, Uysal SR, Hokelek M, Uyar Y, Bernay F, Ariturk E. Multiple organ involvement hydatid cysts in a 2-year-old boy. J. Trop. Pediatr. 2004; 50: 374-6.
Cam I, Çakır Ö, Yılmaz AT, Genez S, Anık Y. Unusual presentation of multi-organ hydatid cysts in a child. Balkan Med. J. 2019; 36: 292-3.
Sabouni F, Ferdosian F, Mamishi S, Nejat F, Monnajemzadeh M, Rezaei N. Multiple organ involvement with hydatid cysts. Iran. J. Parasitol. 2010; 10: 65-70.
Mishra PK, Agrawal A, Joshi M, Sanghvi B, Gupta R, Parelkar SV. Minimal access surgery for multiorgan hydatid cysts. Afr. J. Paediatr. Surg. 2010; 7: 40-2.
Emilio C, Losurdo G, Mollero L, Giacchino R. Multiorgan echinococcosis in a pediatric patient. Pediatr. Infect. Dis. J. 2005; 24: 660-1.
Shabbir MU, Ahmed A, Shaukat F et al. Disseminated hydatid disease in a child involving multiple organ systems: A case report. Cureus 2020; 12: e6564.
Taş T, Pirinççioğlu AG, Günel ME, Fidan M, Taş MA. Multiple organ involvement of hydatid cyst İn 7-year-old girl. Int. Archives Med. Res. 2011; 1: 43-6.
Kaya Z, Gursel T. A pediatric case of desseminated cystic echinococcosis successfully treated with mebendazole. Jpn. J. Infect. Dis. 2004; 57: 7-9.
Olmez D, Babayigit A, Arslan H et al. Multiorgan involvement in a pediatric patient with hydatid disease. J. Trop. Pediatr. 2008; 54: 417-9.
Behera S, Bawa M, Kanojia RP. Echinococcosis in a pediatric patiens. Indian J. Pediatr. 2021; 88: 1147-8.
Harjai MM, Saxena S, Devgan A, Kakkar K. Disseminated hydatid disease in a child. Eur. J. Pediatr. Surg. 2009; 19: 251-71.
Biava MF, Dao A, Fortier B. Laboratory diagnosis of ctstic hydatic disease. World J. Surg. 2001; 25: 10-4.
Altıntoprak F. Complications of hydatid cyst. Sakaryam j. 2012; 2: 216-7.
Atmatzidis KS, Pavlidis TE, Papaziogas BT, Mirelis C, Papaziogas TB. Recurrence and long-term outcome after open cystectomy with omentoplasty for hepatic hydatid disease in an endemic area. Acta Chir. Belg. 2005; 105: 198-202.
Bedioui H, Ayari H, Bouslama K et al. Recurrence of hydatid cyst of liver: Predictive factors: Tunisian experience. Bulletin de la Société de pathologie exotique 1990; 2012: 265-9.