Vectorial Release of Human RNA Viruses from Epithelial Cells.


Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
25 01 2022
Historique:
received: 15 12 2021
revised: 07 01 2022
accepted: 21 01 2022
entrez: 26 2 2022
pubmed: 27 2 2022
medline: 17 3 2022
Statut: epublish

Résumé

Epithelial cells are apico-basolateral polarized cells that line all tubular organs and are often targets for infectious agents. This review focuses on the release of human RNA virus particles from both sides of polarized human cells grown on transwells. Most viruses that infect the mucosa leave their host cells mainly via the apical side while basolateral release is linked to virus propagation within the host. Viruses do this by hijacking the cellular factors involved in polarization and trafficking. Thus, understanding epithelial polarization is essential for a clear understanding of virus pathophysiology.

Identifiants

pubmed: 35215825
pii: v14020231
doi: 10.3390/v14020231
pmc: PMC8875463
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Sabine Chapuy-Regaud (S)

Department of Virology, CHU Purpan, F-31059 Toulouse, France.
INFINITy (Toulouse Institute for Infectious and Inflammatory Diseases), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, CHU Purpan, F-31024 Toulouse, France.

Claire Allioux (C)

INFINITy (Toulouse Institute for Infectious and Inflammatory Diseases), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, CHU Purpan, F-31024 Toulouse, France.

Nicolas Capelli (N)

Department of Virology, CHU Purpan, F-31059 Toulouse, France.
INFINITy (Toulouse Institute for Infectious and Inflammatory Diseases), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, CHU Purpan, F-31024 Toulouse, France.

Marion Migueres (M)

Department of Virology, CHU Purpan, F-31059 Toulouse, France.
INFINITy (Toulouse Institute for Infectious and Inflammatory Diseases), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, CHU Purpan, F-31024 Toulouse, France.

Sébastien Lhomme (S)

Department of Virology, CHU Purpan, F-31059 Toulouse, France.
INFINITy (Toulouse Institute for Infectious and Inflammatory Diseases), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, CHU Purpan, F-31024 Toulouse, France.

Jacques Izopet (J)

Department of Virology, CHU Purpan, F-31059 Toulouse, France.
INFINITy (Toulouse Institute for Infectious and Inflammatory Diseases), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, CHU Purpan, F-31024 Toulouse, France.

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