MicroRNA-profiling of miR-371~373- and miR-302/367-clusters in serum and cerebrospinal fluid identify patients with intracranial germ cell tumors.
Intracranial germ cell tumors
Liquid biopsy
miR-302d
miR-367
miR-371
miR-372
Journal
Journal of cancer research and clinical oncology
ISSN: 1432-1335
Titre abrégé: J Cancer Res Clin Oncol
Pays: Germany
ID NLM: 7902060
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
05
11
2021
accepted:
31
12
2021
pubmed:
17
2
2022
medline:
18
2
2023
entrez:
16
2
2022
Statut:
ppublish
Résumé
Intracranial germ cell tumors (iGCT) comprise germinoma and non-germinoma. Their diagnosis predominantly relies on biopsy as only one-fifth of patients present with elevated biomarkers (AFP/ß-HCG) in serum or cerebrospinal fluid (CSF). MicroRNAs (miR/miRNA) have emerged as non-invasive biomarkers in extracranial GCT and may potentially facilitate non-invasive diagnosis in iGCT. We analyzed eight miRNAs in serum and CSF from the miR-371~373- and miR-302/367-clusters and four miRNAs differentially expressed in iGCT tissue (miR-142-5p/miR-146a-5p/miR-335-5p/miR-654-3p) from eight iGCT patients (age 10-33 years) and 12 control subjects by pre-amplified RT-qPCR. MiR-30b-5p (serum) and miR-204-5p (CSF) acted as reference genes. ΔC Between iGCT and control patients' serum ΔC With the largest data set so far, we underline the suitability of miR-371a, miR-372, miR-367 and miR-302d in serum and CSF for diagnosis of iGCT, particularly in biomarker-negative germinoma. Diagnosis of iGCT by miRNA analysis is a feasible and valid approach, particularly as serum can be readily obtained by a less invasive procedure. MiRNA analysis may discriminate iGCT from other tumors with similar radiological findings and may allow to monitor response to therapy as well as early relapse during follow-up.
Identifiants
pubmed: 35171328
doi: 10.1007/s00432-022-03915-4
pii: 10.1007/s00432-022-03915-4
pmc: PMC9931786
doi:
Substances chimiques
MicroRNAs
0
Biomarkers
0
Biomarkers, Tumor
0
MIRN204 microRNA, human
0
MIRN371 microRNA, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
791-802Subventions
Organisme : Deutsche Kinderkrebsstiftung
ID : DKS2017.19
Informations de copyright
© 2022. The Author(s).
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