The oncogenic fusion landscape in pediatric CNS neoplasms.
Brain tumor
Kinase
Oncogenic fusion protein
Pediatric CNS tumors
Transcription factor
Journal
Acta neuropathologica
ISSN: 1432-0533
Titre abrégé: Acta Neuropathol
Pays: Germany
ID NLM: 0412041
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
22
12
2021
accepted:
31
01
2022
revised:
31
01
2022
pubmed:
17
2
2022
medline:
12
4
2022
entrez:
16
2
2022
Statut:
ppublish
Résumé
Pediatric neoplasms in the central nervous system (CNS) are the leading cause of cancer-related deaths in children. Recent developments in molecular analyses have greatly contributed to a more accurate diagnosis and risk stratification of CNS tumors. Additionally, sequencing studies have identified various, often entity specific, tumor-driving events. In contrast to adult tumors, which often harbor multiple mutated oncogenic drivers, the number of mutated genes in pediatric cancers is much lower and many tumors can have a single oncogenic driver. Moreover, in children, much more than in adults, fusion proteins play an important role in driving tumorigenesis, and many different fusions have been identified as potential driver events in pediatric CNS neoplasms. However, a comprehensive overview of all the different reported oncogenic fusion proteins in pediatric CNS neoplasms is still lacking. A better understanding of the fusion proteins detected in these tumors and of the molecular mechanisms how these proteins drive tumorigenesis, could improve diagnosis and further benefit translational research into targeted therapies necessary to treat these distinct entities. In this review, we discuss the different oncogenic fusions reported in pediatric CNS neoplasms and their structure to create an overview of the variety of oncogenic fusion proteins to date, the tumor entities they occur in and their proposed mode of action.
Identifiants
pubmed: 35169893
doi: 10.1007/s00401-022-02405-8
pii: 10.1007/s00401-022-02405-8
pmc: PMC8960661
doi:
Substances chimiques
Oncogene Proteins, Fusion
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
427-451Informations de copyright
© 2022. The Author(s).
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