Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects.
Hippo pathway
LATS
MST
YAP
apoptosis
caspase
pancreatic islets
type 2 diabates
β cells
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Jan 2022
07 Jan 2022
Historique:
received:
05
11
2021
revised:
20
12
2021
accepted:
05
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
11
2
2022
Statut:
epublish
Résumé
Diabetes mellitus is a heterogeneous disease of complex etiology and pathogenesis. Hyperglycemia leads to many serious complications, but also directly initiates the process of β cell apoptosis. A potential strategy for the preservation of pancreatic β cells in diabetes may be to inhibit the implementation of pro-apoptotic pathways or to enhance the action of pancreatic protective factors. The Hippo signaling pathway is proposed and selected as a target to manipulate the activity of its core proteins in therapy-basic research. MST1 and LATS2, as major upstream signaling kinases of the Hippo pathway, are considered as target candidates for pharmacologically induced tissue regeneration and inhibition of apoptosis. Manipulating the activity of components of the Hippo pathway offers a wide range of possibilities, and thus is a potential tool in the treatment of diabetes and the regeneration of β cells. Therefore, it is important to fully understand the processes involved in apoptosis in diabetic states and completely characterize the role of this pathway in diabetes. Therapy consisting of slowing down or stopping the mechanisms of apoptosis may be an important direction of diabetes treatment in the future.
Identifiants
pubmed: 35054822
pii: ijms23020636
doi: 10.3390/ijms23020636
pmc: PMC8775644
pii:
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Tumor Suppressor Proteins
0
LATS2 protein, human
EC 2.7.1.11
STK4 protein, human
EC 2.7.1.11
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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