SUCCOR cone study: conization before radical hysterectomy.
Adult
Conization
/ statistics & numerical data
Databases, Factual
Disease-Free Survival
Female
Humans
Hysterectomy
/ statistics & numerical data
Middle Aged
Minimally Invasive Surgical Procedures
Neoplasm Recurrence, Local
/ prevention & control
Propensity Score
Retrospective Studies
Uterine Cervical Neoplasms
/ pathology
cervical cancer
hysterectomy
laparoscopes
laparotomy
surgery
Journal
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
ISSN: 1525-1438
Titre abrégé: Int J Gynecol Cancer
Pays: England
ID NLM: 9111626
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
28
02
2021
accepted:
06
12
2021
pubmed:
19
1
2022
medline:
12
3
2022
entrez:
18
1
2022
Statut:
ppublish
Résumé
To evaluate disease-free survival of cervical conization prior to radical hysterectomy in patients with stage IB1 cervical cancer (International Federation of Gynecology and Obstetrics (FIGO) 2009). A multicenter retrospective observational cohort study was conducted including patients from the Surgery in Cervical Cancer Comparing Different Surgical Aproaches in Stage IB1 Cervical Cancer (SUCCOR) database with FIGO 2009 IB1 cervical carcinoma treated with radical hysterectomy between January 1, 2013, and December 31, 2014. We used propensity score matching to minimize the potential allocation biases arising from the retrospective design. Patients who underwent conization but were similar for other measured characteristics were matched 1:1 to patients from the non-cone group using a caliper width ≤0.2 standard deviations of the logit odds of the estimated propensity score. We obtained a weighted cohort of 374 patients (187 patients with prior conization and 187 non-conization patients). We found a 65% reduction in the risk of relapse for patients who had cervical conization prior to radical hysterectomy (hazard ratio (HR) 0.35, 95% confidence interval (CI) 0.16 to 0.75, p=0.007) and a 75% reduction in the risk of death for the same sample (HR 0.25, 95% CI 0.07 to 0.90, p=0.033). In addition, patients who underwent minimally invasive surgery without prior conization had a 5.63 times higher chance of relapse compared with those who had an open approach and previous conization (HR 5.63, 95% CI 1.64 to 19.3, p=0.006). Patients who underwent minimally invasive surgery with prior conization and those who underwent open surgery without prior conization showed no differences in relapse rates compared with those who underwent open surgery with prior cone biopsy (reference) (HR 1.94, 95% CI 0.49 to 7.76, p=0.349 and HR 2.94, 95% CI 0.80 to 10.86, p=0.106 respectively). In this retrospective study, patients undergoing cervical conization before radical hysterectomy had a significantly lower risk of relapse and death.
Identifiants
pubmed: 35039455
pii: ijgc-2021-002544
doi: 10.1136/ijgc-2021-002544
doi:
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
117-124Investigateurs
Nabil Abdalla
(N)
Sedat Akgöl
(S)
Demirkiran Aksahin
(D)
Shamistan Aliyev
(S)
Maria Alonso-Espias
(M)
Igor Aluloski
(I)
Claudia Andrade
(C)
Nikola Badzakov
(N)
Rosa Barrachina
(R)
Giorgio Bogani
(G)
Eduard-Aexandru Bonci
(EA)
Hélène Bonsang-Kitzis
(H)
Cosima Brucker
(C)
Laura Cárdenas
(L)
Andrea Casajuana
(A)
Pere Cavalle
(P)
Jorge Cea
(J)
Benito Chiofalo
(B)
Gloria Cordeiro
(G)
Pluvio Coronado
(P)
Maria Cuadra
(M)
Javier Díez
(J)
Teresa Diniz da Costa
(TDD)
Santiago Domingo
(S)
Lukas Dostalek
(L)
Fuat Elif
(F)
Diego Erasun
(D)
Mathias Fehr
(M)
Sergi Fernandez-Gonzalez
(S)
Annamaria Ferrero
(A)
Soledad Fidalgo
(S)
Gabriel Fiol
(G)
Khadra Galaal
(K)
José García
(J)
Gerhard Gebauer
(G)
Fabio Ghezzi
(F)
Juan Gilabert
(J)
Nana Gomes
(N)
Elisabete Gonçalves
(E)
Virginia Gonzalez
(V)
Frederic Grandjean
(F)
Miriam Guijarro
(M)
Frédéric Guyon
(F)
Jolien Haesen
(J)
Gines Hernandez-Cortes
(G)
Sofía Herrero
(S)
Imre Pete
(I)
Ioannis Kalogiannidis
(I)
Erbil Karaman
(E)
Andreas Kavallaris
(A)
Lukasz Klasa
(L)
Ioannis Kotsopoulos
(I)
Stefan Kovachev
(S)
Uppin Arno Leht
(UA)
Arantxa Lekuona
(A)
Mathieu Luyckx
(M)
Michael Mallmann
(M)
Gemma Mancebo
(G)
Aljosa Mandic
(A)
Tiermes Marina
(T)
Victor Martin
(V)
María Belén Martín-Salamanca
(MB)
Víctor Lago
(V)
Alejandra Martinez
(A)
Gesine Meili
(G)
Gustavo Mendinhos
(G)
Liliana Mereu
(L)
Milena Mitrovic
(M)
Sara Morales
(S)
Enrique Moratalla
(E)
Natalia R Gómez-Hidalgo
(NR)
Bibiana Morillas
(B)
Eva Myriokefalitaki
(E)
Maja PakižImre
(M)
Imre Pete
(I)
Stamatios Petousis
(S)
Laurentiu Pirtea
(L)
Natalia Povolotskaya
(N)
Sonia Prader
(S)
Alfonso Quesada
(A)
Mikuláš Redecha
(M)
Fernando Roldan
(F)
Philip Rolland
(P)
Reeli Saaron
(R)
Cosmin-Paul Sarac
(CP)
Jens-Peter Scharf
(JP)
Špela Smrkolj
(Š)
Rita Sousa
(R)
Artem Stepanyan
(A)
Vladimír Študent
(V)
Carmen Tauste
(C)
Hans Trum
(H)
Taner Turan
(T)
Manuela Undurraga
(M)
Alicia Vázquez
(A)
Ignace Vergote
(I)
George Vorgias
(G)
Ignacio Zapardiel
(I)
Commentaires et corrections
Type : CommentIn
Informations de copyright
© IGCS and ESGO 2022. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.