Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019.
HIV infection/*epidemiology
coinfection/*epidemiology
hepatitis C/drug therapy/*epidemiology
Journal
HIV medicine
ISSN: 1468-1293
Titre abrégé: HIV Med
Pays: England
ID NLM: 100897392
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
revised:
17
12
2021
received:
01
10
2021
accepted:
23
12
2021
pubmed:
18
1
2022
medline:
14
7
2022
entrez:
17
1
2022
Statut:
ppublish
Résumé
We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018. The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation. The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001). In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population.
Identifiants
pubmed: 35037379
doi: 10.1111/hiv.13229
pmc: PMC9543728
doi:
Substances chimiques
Antiviral Agents
0
RNA
63231-63-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
705-716Investigateurs
C Fanciulli
(C)
L Pérez-Latorre
(L)
T Aldámiz
(T)
C Díez
(C)
F Tejerina
(F)
S Carretero
(S)
I Gutiérrez
(I)
M Ramírez
(M)
B Padilla
(B)
J C López
(JC)
J Berenguer
(J)
M J Núñez
(MJ)
F Arnalich
(F)
J R Arribas
(JR)
J I Bernardino
(JI)
C Busca
(C)
A Delgado
(A)
V Hontañón
(V)
M L Martín-Carbonero
(ML)
R Micán
(R)
R Montejano
(R)
M L Montes
(ML)
V Moreno
(V)
I Pérez-Valero
(I)
C Navarro
(C)
E Valencia
(E)
J González-García
(J)
A Rivero-Juárez
(A)
T Brieva
(T)
I Machuca
(I)
A Camacho
(A)
A Rivero-Román
(A)
I Jarrín
(I)
M J Vivancos
(MJ)
S Moreno
(S)
A Moreno
(A)
J L Casado
(JL)
M J Pérez-Elías
(MJ)
C Quereda
(C)
A Torrella
(A)
B Planas
(B)
J Navarro
(J)
M Rodrigo
(M)
V Estrada
(V)
J Vergas
(J)
M J Téllez
(MJ)
J Muñoz
(J)
M Gutiérrez
(M)
G Mateo
(G)
J M Guardiola
(JM)
M Ibarguren
(M)
M P Carmona
(MP)
F Rodríguez-Arrondo
(F)
M A Goenaga
(MA)
H Azkune
(H)
M A Von Wichmann
(MA)
J A Iribarren
(JA)
J Carmena
(J)
A Artero
(A)
E Prado-González
(E)
G Piera-Rojo
(G)
A Ocampo
(A)
C Miralles
(C)
M Crespo
(M)
Morano L
(M)
J Ruiz
(J)
E Nuño
(E)
R Palacios
(R)
J Santos
(J)
M Márquez
(M)
J Sanz
(J)
I Santos
(I)
J Moreno
(J)
P Arazo
(P)
M Montero
(M)
M Tasias
(M)
S Cuellar
(S)
E Calabuig
(E)
M Blanes
(M)
J Fernández
(J)
J López-Aldeguer
(J)
M Salavert
(M)
A Hernando
(A)
L Domínguez
(L)
O Bisbal
(O)
M De Lagarde
(M)
M Matarranz
(M)
R Rubio
(R)
F Pulido
(F)
C García
(C)
C Armiñanzas
(C)
S Echevarría
(S)
M Gutiérrez-Cuadra
(M)
C Fariñas
(C)
L Giner
(L)
S Reus
(S)
E Merino
(E)
V Boix
(V)
D Torrús
(D)
I Portilla
(I)
M Pampliega
(M)
M Díez
(M)
I Egea
(I)
J Portilla
(J)
O L Ferrero
(OL)
S Ibarra
(S)
I López
(I)
M de la Peña
(M)
Z Zubero
(Z)
J Baraia
(J)
J Muñoz
(J)
J de Miguel
(J)
A Arranz
(A)
E Casas
(E)
J Sanz
(J)
A Ferrer
(A)
M J Galindo
(MJ)
L García
(L)
L Pérez
(L)
J A Oteo
(JA)
M Velasco
(M)
L Moreno
(L)
R Hervás
(R)
J E Losa
(JE)
D Vinuesa
(D)
L Muñoz
(L)
J Hernández-Quero
(J)
S Veloso
(S)
J Peraire
(J)
C Viladés
(C)
M Vargas
(M)
A Castellano
(A)
F Vidal
(F)
R Silvariño
(R)
A J Orti
(AJ)
E Chamarro
(E)
C Escrig
(C)
P Geijo
(P)
A Chocarro
(A)
C Rodríguez
(C)
T Puerta
(T)
M Raposo
(M)
M Vera
(M)
J Del Romero
(J)
J Bisbe
(J)
C Cifuentes
(C)
R Teira
(R)
J Vilaró
(J)
A Vegas
(A)
A Cano
(A)
A Alcaráz
(A)
A Muñoz
(A)
E Bernal
(E)
M Campoamor
(M)
M J Tuya
(MJ)
B de la Fuente
(B)
A Gimeno
(A)
C Montero
(C)
S Arponen
(S)
L Force
(L)
P Barrufet
(P)
G Gaspar
(G)
G Alonso
(G)
C Toledo
(C)
A I Peláez
(AI)
G Lara
(G)
I Fernández
(I)
M C Esteban
(MC)
Informations de copyright
© 2022 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.
Références
AIDS. 2012 Nov 13;26(17):2241-6
pubmed: 22781223
J Hepatol. 2020 May;72(5):855-864
pubmed: 31862485
Lancet HIV. 2021 Feb;8(2):e96-e105
pubmed: 33357835
Liver Int. 2019 Mar;39(3):416-426
pubmed: 30472772
Open Forum Infect Dis. 2016 Mar 11;3(2):ofw059
pubmed: 27186584
Clin Infect Dis. 2009 May 15;48(10):1467-70
pubmed: 19368502
Hepatology. 2009 Aug;50(2):407-13
pubmed: 19575364
J Viral Hepat. 2018 Jun;25(6):680-698
pubmed: 29345844
Semin Liver Dis. 2012 May;32(2):130-7
pubmed: 22760652
Clin Infect Dis. 2001 Aug 15;33(4):562-9
pubmed: 11462196
Hepatology. 1999 Oct;30(4):1054-8
pubmed: 10498659
AIDS. 2019 Mar 15;33(4):685-689
pubmed: 30829744
Enferm Infecc Microbiol Clin. 2005 Jun-Jul;23(6):340-8
pubmed: 15970166
HIV Med. 2019 Apr;20(4):264-273
pubmed: 30734998
Euro Surveill. 2019 Jul;24(30):
pubmed: 31362808
Clin Infect Dis. 2012 Sep;55(5):728-36
pubmed: 22610932
Clin Infect Dis. 2000 Apr;30 Suppl 1:S77-84
pubmed: 10770916
Clin Infect Dis. 2019 Nov 27;69(12):2127-2135
pubmed: 30810158
HIV Med. 2022 Aug;23(7):705-716
pubmed: 35037379
N Engl J Med. 2014 May 22;370(21):2043-7
pubmed: 24795199
Hepatology. 2018 Jul;68(1):32-47
pubmed: 29377274
Open Forum Infect Dis. 2018 Jan 12;5(1):ofx258
pubmed: 29354658
Clin Infect Dis. 2014 Mar;58(5):719-27
pubmed: 24285848
Clin Infect Dis. 2020 Sep 12;71(6):1502-1510
pubmed: 31585005