Bone Marrow Transplantation Rescues Monocyte Recruitment Defect and Improves Cystic Fibrosis in Mice.
Animals
Bone Marrow Transplantation
Bronchoalveolar Lavage Fluid
/ cytology
Cell Adhesion
/ genetics
Colitis
/ pathology
Cystic Fibrosis
/ pathology
Cystic Fibrosis Transmembrane Conductance Regulator
/ genetics
Integrins
/ metabolism
Intestinal Mucosa
/ cytology
Mice
Mice, Inbred C57BL
Monocytes
/ immunology
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 02 2022
01 02 2022
Historique:
received:
25
09
2021
accepted:
19
11
2021
pubmed:
16
1
2022
medline:
10
2
2022
entrez:
15
1
2022
Statut:
ppublish
Résumé
Cystic fibrosis (CF) is an inherited life-threatening disease accompanied by repeated lung infections and multiorgan inflammation that affects tens of thousands of people worldwide. The causative gene, cystic fibrosis transmembrane conductance regulator (CFTR), is mutated in CF patients. CFTR functions in epithelial cells have traditionally been thought to cause the disease symptoms. Recent work has shown an additional defect: monocytes from CF patients show a deficiency in integrin activation and adhesion. Because monocytes play critical roles in controlling infections, defective monocyte function may contribute to CF progression. In this study, we demonstrate that monocytes from CFTR
Identifiants
pubmed: 35031577
pii: jimmunol.1901171
doi: 10.4049/jimmunol.1901171
pmc: PMC8855460
mid: NIHMS1759059
doi:
Substances chimiques
Cftr protein, mouse
0
Integrins
0
Cystic Fibrosis Transmembrane Conductance Regulator
126880-72-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
745-752Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL078784
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL151433
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA262430
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL145454
Pays : United States
Informations de copyright
Copyright © 2022 by The American Association of Immunologists, Inc.
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