Neurobiology of cancer: Definition, historical overview, and clinical implications.
adrenergic signaling
epinephrine
hypothalamic-pituitary-adrenocortical axis
innervation
neurobiology of cancer
norepinephrine
propranolol
psychoneuroimmunology
stress
sympathoadrenal system
β-blockers
Journal
Cancer medicine
ISSN: 2045-7634
Titre abrégé: Cancer Med
Pays: United States
ID NLM: 101595310
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
15
11
2021
received:
18
07
2021
accepted:
17
11
2021
pubmed:
26
12
2021
medline:
19
4
2022
entrez:
25
12
2021
Statut:
ppublish
Résumé
Studies published in the last two decades have clearly demonstrated that the nervous system plays a significant role in carcinogenesis, the progression of cancer, and the development of metastases. These studies, combining oncological and neuroscientific approaches, created the basis for the emergence of a new field in oncology research, the so-called "neurobiology of cancer." The concept of the neurobiology of cancer is based on several facts: (a) psychosocial factors influence the incidence and progression of cancer diseases; (b) the nervous system affects DNA mutations and oncogene-related signaling; (c) the nervous system modulates tumor-related immune responses; (d) tumor tissues are innervated; (e) neurotransmitters released from nerves innervating tumor tissues affect tumor growth and metastasis; (f) alterations or modulation of nervous system activity affects the incidence and progression of cancers; (g) tumor tissue affects the nervous system. The aim of this review is to characterize the pillars that create the basis of cancer neurobiology, to describe recent research advances of the nervous system's role in cancer diseases, and to depict potential clinical implications for oncology.
Identifiants
pubmed: 34953048
doi: 10.1002/cam4.4488
pmc: PMC8855902
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
903-921Informations de copyright
© 2021 The Author. Cancer Medicine published by John Wiley & Sons Ltd.
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