Effect of S-Se Bioisosteric Exchange on Affinity and Intrinsic Efficacy of Novel
A2A receptor
N-acylhydrazone derivatives
N-methylation effect
chalcogen interaction
conformational effect
sulfur-selenium isosterism
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
04 Dec 2021
04 Dec 2021
Historique:
received:
23
10
2021
revised:
29
11
2021
accepted:
30
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
11
2
2022
Statut:
epublish
Résumé
In this work, we evaluated the conformational effect promoted by the isosteric exchange of sulfur by selenium in the heteroaromatic ring of new
Identifiants
pubmed: 34885946
pii: molecules26237364
doi: 10.3390/molecules26237364
pmc: PMC8659164
pii:
doi:
Substances chimiques
Adenosine A2 Receptor Agonists
0
Hydrazones
0
LASSBio 294
0
LASSBio-785
0
Receptor, Adenosine A2A
0
Thiophenes
0
Sulfur
70FD1KFU70
Selenium
H6241UJ22B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Institute of Science and Technology of Drugs and Medicines
ID : 465.249/2014-0
Organisme : National Council for Scientific and Technological Development
ID : 104.047/2018-6
Organisme : Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
ID : E-26/010.000090/2018
Organisme : Coordenação de Aperfeicoamento de Pessoal de Nível Superior
ID : 88887.3182253/2019-00 and 88887.318248/2019-00
Références
Naunyn Schmiedebergs Arch Pharmacol. 2015 Mar;388(3):363-80
pubmed: 25432095
Pharmaceuticals (Basel). 2018 Nov 01;11(4):
pubmed: 30388818
Chem Rev. 2011 Sep 14;111(9):5215-46
pubmed: 21631125
Eur J Med Chem. 2000 Feb;35(2):187-203
pubmed: 10758281
J Mol Model. 2007 Oct;13(10):1033-8
pubmed: 17647029
J Mol Graph Model. 2010 Jan;28(5):446-54
pubmed: 19942466
J Pharmacol Toxicol Methods. 2017 Mar - Apr;84:51-56
pubmed: 27810394
Bioorg Med Chem Lett. 2010 Jun 15;20(12):3734-6
pubmed: 20488703
J Pharmacol Toxicol Methods. 2014 Jul-Aug;70(1):12-8
pubmed: 24636913
J Mol Model. 2009 Jun;15(6):723-9
pubmed: 19082643
Br J Pharmacol. 2002 Jan;135(1):293-8
pubmed: 11786506
Am J Hypertens. 2010 Nov;23(11):1220-7
pubmed: 20671720
Bioorg Med Chem Lett. 2018 Sep 15;28(17):2797-2806
pubmed: 30006065
J Biol Chem. 1951 Nov;193(1):265-75
pubmed: 14907713
Bioorg Med Chem. 2005 May 16;13(10):3431-7
pubmed: 15848755
J Med Chem. 2012 Sep 13;55(17):7525-45
pubmed: 22891752
Drug Des Devel Ther. 2017 Mar 06;11:553-562
pubmed: 28293100
Br J Pharmacol. 2001 Oct;134(3):603-13
pubmed: 11588115
Eur J Med Chem. 2009 Oct;44(10):4004-9
pubmed: 19500884
J Pharmacol Exp Ther. 2001 Nov;299(2):558-66
pubmed: 11602667
Life Sci. 2014 Jan 14;94(1):30-6
pubmed: 24269214
J Am Chem Soc. 2017 Oct 25;139(42):15160-15167
pubmed: 28985065
J Med Chem. 1983 Aug;26(8):1187-92
pubmed: 6876087