The effect of fatty diacid acylation of human PYY
Acetylation
Animals
Anti-Obesity Agents
/ administration & dosage
CHO Cells
Cricetinae
Cricetulus
Drug Combinations
Fatty Acids
/ chemistry
Female
HEK293 Cells
Half-Life
Humans
Liraglutide
/ administration & dosage
Obesity
/ drug therapy
Oligopeptides
/ administration & dosage
Peptide YY
/ chemistry
Protein Binding
Receptors, Neuropeptide Y
/ metabolism
Swine
Swine, Miniature
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 10 2021
27 10 2021
Historique:
received:
15
07
2021
accepted:
13
10
2021
entrez:
28
10
2021
pubmed:
29
10
2021
medline:
27
1
2022
Statut:
epublish
Résumé
Peptides are notoriously known to display very short in vivo half-lives often measured in minutes which in many cases greatly reduces or eliminates sufficient in vivo efficacy. To obtain long half-lives allowing for up to once-weekly dosing regimen, fatty acid acylation (lipidation) have been used to non-covalently associate the peptide to serum albumin thus serving as a circulating depot. This approach is generally considered in the scientific and patent community as a standard approach to protract almost any given peptide. However, it is not trivial to prolong the half-life of peptides by lipidation and still maintain high potency and good formulation properties. Here we show that attaching a fatty acid to the obesity-drug relevant peptide PYY
Identifiants
pubmed: 34707178
doi: 10.1038/s41598-021-00654-3
pii: 10.1038/s41598-021-00654-3
pmc: PMC8551270
doi:
Substances chimiques
Anti-Obesity Agents
0
Drug Combinations
0
Fatty Acids
0
Oligopeptides
0
Receptors, Neuropeptide Y
0
Peptide YY
106388-42-5
Liraglutide
839I73S42A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
21179Informations de copyright
© 2021. The Author(s).
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